Constructing the prediction model based on DXA between sarcopenia and BMD in middle-aged and elderly men with T2DM.

Objective: To explore the relationship between sarcopenia and bone mineral density (BMD) in middle-aged and elderly male patients with type 2 diabetes mellitus (T2DM), construct a prediction model for sarcopenia based on dual-energy X-ray absorptiometry (DXA), and evaluate its clinical value.

Methods: A total of 523 middle-aged and elderly male patients with T2DM in the hospital from January 2021 to December 2024 were selected and divided into the training set (366 cases) and the validation set (157 cases) at a ratio of 7:3. The BMD -value was measured by DXA, and clinical data were collected.

Recent advances in organic molecule fluorescent probes for microbial imaging.

Microorganisms play a crucial role in human life and production. However, certain pathogenic microorganisms, such as bacteria, viruses, and fungi, can cause diseases like pneumonia, meningitis, and influenza, potentially leading to global public health crises. Fluorescence imaging has become a key tool for microbial detection due to its high specificity, sensitivity, and operational convenience.

The Impact of Sarcopenic Obesity on Weight Loss Outcomes and Recurrent Weight Gain Following Laparoscopic Sleeve Gastrectomy.

Background: Sarcopenic obesity (SO) presents a significant public health challenge. Although the prevalence of SO is on the rise, there is a notable paucity of research examining the impact of SO on weight loss efficacy following laparoscopic sleeve gastrectomy (LSG).

Purpose: To investigate the impact of SO on weight loss outcomes and recurrent weight gain following LSG.

Blood-Brain Barrier-Crossing Photo-oxygenation Nanocomposite for the Selective Mapping and Disassembly of Amyloid-β Aggregates In Vivo.

The accumulation of toxic amyloid-β (Aβ) aggregates in the brain underlies neuronal death and subsequent irreversible neurodegeneration in Alzheimer's disease (AD). Currently, optimized theranostic probes targeting Aβ aggregates are still rare. Herein, we synthesized a series of tetraphenylethylene (TPE) derivatives for the selective recognition and photo-oxygenation of Aβ aggregates.

A Sensor Array Composed of Organelle-Targeting Fluorescent Probes and Polydopamine Particles for Deep Learning-Assisted Identification and Ablation of Drug-Resistant Lung Tumors.

Lung cancer, a leading cause of global cancer-related mortality, predominantly features nonsmall cell lung cancer (NSCLC), constituting 80% of all lung malignancies. Despite chemotherapy being the primary NSCLC treatment, the emergence of drug resistance poses a significant challenge. Identifying drug-resistant cells and characterizing the resistance type is crucial for guiding clinical interventions in NSCLC.

A positively charged sensor array for identification of microorganisms using fluorescence response patterns.

Microorganisms, such as bacteria and fungi, are ubiquitous and closely related to human life and health. The identification of microorganisms is especially important in the diagnosis of diseases. Herein, three positively charged tetraphenylethylene derivatives (PCTs) were successfully synthesized and used to form a sensor array (PCTs-Sa) to identify microorganisms.

Unraveling the relationship between metabolic syndrome and epigenetic aging: evidence from NHANES 1999-2002 and Mendelian randomization study.

Background: Epigenetic age acceleration (EAA), reflecting the difference between biological and chronological age, serves as a novel biomarker for biological aging. Evidence shows metabolic syndrome (MetS) affects aging-related physiology, but the relationship between MetS and EAA remains unclear and warrants further investigation.

Methods: We analyzed data from 1972 individuals in the National Health and Nutrition Examination Survey (NHANES) 1999-2002.

Lysosome-Targeted Si-rhodamine Derivative for NO Imaging in Mice Brain with Neurological Diseases.

Nitric oxide (NO) is an intracellular and intercellular messenger, regulating cellular functions in different manners. Intracellular vesicular acidic compartments, such as lysosomes, are essential digestive organelles of the cells, where the abnormal changes of NO concentration can alter the microenvironmental change and are related with the progression of various diseases, for instance, neuroinflammation and Wadatson's disease. Herein, we presented as an effective lysosome-targeted NIR fluorescent probe for the sensing, which was applied in detecting NO level changes in the brain with neuroinflammation.

Dvelopment and application of similar material for physical model test of an ultradeep foundation pit in round gravel strata.

The raw-material mix ratio and preparation of similar materials are crucial for the success of physical model tests and for accurately reflecting prototype properties. In this study, an optimum similar material for plateau alluvial and lacustrine (PAL) round gravel was developed based on similarity theory. The similar materials were subjected to sensitivity factor analysis and microscopic analysis.

The P2X7R/NLRP3 inflammasome axis suppresses enthesis regeneration through inflammatory and metabolic macrophage-stem cell cross-talk.

The regeneration of the enthesis remains a formidable challenge in regenerative medicine. However, key regulators underlying unsatisfactory regeneration remain poorly understood. This study reveals that the purinergic receptor P2X7 (P2X7R)/Nod-like receptor family protein 3 (NLRP3) inflammasome axis suppresses enthesis regeneration by amplifying IL-1β-mediated inflammatory cross-talk and suppressing docosatrienoic acid (DTA) metabolic cross-talk.

The relationship between platelet parameters and bacterial types in patients with bacteremia: A retrospective observational study.

Objective: To analyze the relationship between platelet parameters and bacterial types in patients with bacteremia.

Methodology: Data from 265 patients with positive blood bacterial cultures were collected. Clinical parameters and procalcitonin (PCT) were recorded.

Examining the Effect of Research Engagement on the Interest in Integrating Research into Future Career Paths Among Medical Graduates in China: An Instrumental Variable Analysis.

Background: While the importance of physician research has been underscored, a shortage of qualified physicians engaged in research persists. Early exposure to research could potentially ignite medical students' interest in research, thereby motivating them to pursue research-related careers.

Objective: The study aims to examine early research engagement and medical graduates' interest in incorporating research into their future career paths.

Mapping of Amyloid-β Aggregates In Vivo by a Fluorescent Probe with Dual Recognition Moieties.

The spontaneous aggregation of amyloid-β (Aβ) leads to neuronal cell death in the brain and causes the development of Alzheimer's disease (AD). The efficient detection of the aggregation state of Aβ holds significant promise for the early diagnosis and subsequent treatment of this neurodegenerative disorder. Currently, most of the fluorescent probes used for the detection of Aβ fibrils share similar recognition moieties, such as the ,-dimethylamino group, ,-diethylamino group, and piperidyl group.

BODIPY-Based Ratiometric Fluorescent Probe for Sensing Peroxynitrite in Inflammatory Cells and Tissues.

Peroxynitrite (ONOO) plays an important role in many physiological and pathological processes. Excessive ONOO in cells leads to oxidative stress and inflammation. However, precise monitoring of ONOO levels in specific organelles (e.

Interprofessional collaboration in primary care for patients with chronic illness: a scoping review mapping leadership and followership.

Background: Effective interprofessional collaboration (IPC) in primary care is essential in providing high-quality care for patients with chronic illness. However, the traditional role-based leadership approach may hinder IPC. Instead, physicians should also take followership roles, allowing other healthcare team members (OHCTMs) to lead when they have expertise and/or experience.

Interprofessional collaboration in primary care for patients with chronic illness: a scoping review protocol mapping leadership and followership.

Effective interprofessional collaboration (IPC) in primary care is essential for providing high-quality care for patients with chronic illness. However, the traditional role-based leadership approach in which physicians are the sole leaders, may hinder IPC. To improve IPC, leadership roles may need to shift dynamically based on expertise and experience, allowing for fluid transitions between leaders and followers within teams.

Microstructure and Mechanical Properties of NiTi Alloy Prepared by Double-Wire + Arc Additive Manufacturing Plus Heat Treatment.

In this study, NiTi shape memory alloy was prepared by double-wire + arc additive manufacturing plus heat treatment using TA1 and ER-Ni welding wires as the raw materials. The results show that the microstructural evolution from the bottom to top is NiTi + NiTi → NiTi + NiTi + NiTi → NiTi + NiTi + NiTi + NiTi + α-Ti. Complex thermal cycles led to the precipitation of NiTi, which improves the hardness of the matrix (B2), and the average hardness value of the top region reaches 550.

Exosome-loaded biomaterials for tendon/ligament repair.

Exosomes, a specialised type of extracellular vesicle, have attracted significant attention in the realm of tendon/ligament repair as a potential biologic therapeutic tool. While the competence of key substances responsible for the delivery function was gradually elucidated, series of shortcomings exemplified by the limited stability still need to be improved. Therefore, how to take maximum advantage of the biological characteristics of exosomes is of great importance.

Activation of the HMGB1-TLR4 pathway impacts the functionality of bone marrow mesenchymal stem cells and disrupts macrophage polarization in immune thrombocytopenia.

Recent evidence suggests that immune thrombocytopenia (ITP), a common bleeding disorder, is linked to an imbalance in macrophage polarization and impaired bone marrow mesenchymal stem cells (BMSCs). However, the relationship between macrophage polarization imbalance and functional defects in BMSCs, as well as the involvement of associated molecules in BMSCs' defects, is not well understood. This study aimed to investigate the regulatory effects of high mobility group protein 1 (HMGB1) on the physiological functions of BMSCs, specifically in relation to macrophage polarization imbalance.

Unravelling structural features of small molecules for photochemical transformation of environmental contaminants.

Small molecules, including natural metabolites, organic matter decomposition products, and engineered oxidation byproducts, are widespread in aquatic environment. However, the limited understanding of the photochemical interactions of these small molecules with water pollutants hampers the development of effective environmental protection strategies. This study explores the structural features governing the photochemical transformation of toxic oxyanions by α- and β-dicarbonyl compounds.

Bioactive Patch for Rotator Cuff Repairing via Enhancing Tendon-to-Bone Healing: A Large Animal Study and Short-Term Outcome of a Clinical Trial.

Tissue engineering has demonstrated its efficacy in promoting tissue regeneration, and extensive research has explored its application in rotator cuff (RC) tears. However, there remains a paucity of research translating from bench to clinic. A key challenge in RC repair is the healing of tendon-bone interface (TBI), for which bioactive materials suitable for interface repair are still lacking.

Fluffy hybrid nanoadjuvants for reversing the imbalance of osteoclastic and osteogenic niches in osteoporosis.

Osteoporosis is majorly caused by an imbalance between osteoclastic and osteogenic niches. Despite the development of nationally recognized first-line anti-osteoporosis drugs, including alendronate (AL), their low bioavailability, poor uptake rate, and dose-related side effects present significant challenges in treatment. This calls for an urgent need for more effective bone-affinity drug delivery systems.

Empathy in undergraduate medical students: a multi-center cross-sectional study in China.

Background: Fostering empathy has been continuously emphasized in the global medical education. Empathy is crucial to enhance patient-physician relationships, and is associated with medical students' academic and clinical performance. However, empathy level of medical students in China and related influencing factors are not clear.

Identification of Microorganism in Infected Wounds by Positively Charged Selective Sensor Array and Deep Learning Algorithm.

Microorganism are ubiquitous and intimately connected with human health and disease management. The accurate and fast identification of pathogenic microorganisms is especially important for diagnosing infections. Herein, three tetraphenylethylene derivatives (S-TDs: TBN, TPN, and TPI) featuring different cationic groups, charge numbers, emission wavelengths, and hydrophobicities were successfully synthesized.