The Nuss and reverse Nuss procedure paradox: divergent outcomes in scoliosis risk for pectus excavatum and pectus carinatum patients.

Background: Pectus excavatum (PE) and pectus carinatum (PC), structurally opposite chest wall deformities, provides a unique opportunity to investigate the relationship between chest deformities and thoracic scoliosis.

Methods: The study collected 2014 to 2024 medical records and radiological data. Cross-sectional analysis included 1315 PE/PC patients and 5140 matched controls; retrospective cohort analysis included 549 patients.

Molecular pharmacokinetic mechanism of quercetin-encapsulated polymeric micelles in alleviating cisplatin-induced nephrotoxicity and enhancing antineoplastic effects.

Introduction: Cisplatin (DDP), a platinum-based chemotherapy drug, shows broad antineoplastic activity, however, its clinical use is limited by dose-dependent nephrotoxicity, a major challenge in cancer therapy. The purpose of this study was to investigate the mechanism by which quercetin-polyethylene glycol-polycaprolactone (Que-PEG-PCL) micelles simultaneously enhance the cytotoxicity of DDP against cancer cells and reduce its nephrotoxicity.

Methods: Rodent models and HEK293 cells were used to evaluate the renoprotective effects of Que-PEG-PCL micelles.

Multidisciplinary analysis of the prognosis and biological function of NUBPL in gastric cancer.

Background: Researchers are currently concentrating on molecular markers and potential therapeutic targets associated with gastric cancer in light of recent developments in precision medicine and molecular biology. Disulfidptosis was first proposed in 2023 as a novel programmed cell death mode associated with the cytoskeleton. Disulfidptosis-related proteins are essential for the preservation of protein stability and abnormal expression of disulfidptosis-related genes may be linked to cancer development and drug resistance.

PRRX1 is a key regulator in the phenotypic transition between human normal dermal and keloid fibroblasts.

Background: Scarring after skin trauma is a major clinical challenge, as it affects patients' appearance and function.

Objective: Given that human foetal skin possesses scarless wound healing ability, we aimed to understand the differences among human foetal skin, postnatal skin, and keloid tissue to find out the key factors affecting wound healing outcome.

Methods: We used spatial transcriptomics (ST), histological imaging, and other methods to investigate the cellular and molecular characteristics underlying scarless healing by comparing these skin types.

Breaking the Activity-and-Selectivity Seesaw while Enhancing Heat Management via the Lattice Effect of a Single-Atom Alloy.

When single-atom catalysts are oriented toward practical applications, in addition to balancing the seesaw between activity and selectivity, the capability of thermal management also merits attention. Herein, we proposed a facility approach that, based on active Pd in the state of a single atom, tunes the guest Cu size to simultaneously enhance the effect of d-electron domination and the heat transfer behavior in microregions. Along with the Cu size in an order of magnitude increase, more delocalized electrons were generated and transferred to isolated Pd sites, with the d band center shifting from 1.

Palladium/norbornene cooperative catalysis triple functionalization: carbamoylation/double-annulation of (hetero)aryl iodides.

A novel Pd/NBE-catalyzed intermolecular dehydrobicyclization of heteroaryl iodides for the synthesis of polycyclic nitrogen-containing heterocycles is reported. In this work, the -protected aryl carbamoyl chloride serves as a source of acylation. The products resulting from the direct C-H functionalization of heteroaryl iodides are smoothly obtained without catalyst poisoning by heteroatoms.

Inhibition of ERK1/2 mediated activation of Drp1 alleviates intervertebral disc degeneration via suppressing pyroptosis and apoptosis in nucleus pulposus cells.

Objective: Dynamin-related protein 1 (Drp1) plays a crucial role in various inflammatory and degenerative diseases, yet its involvement in intervertebral disc degeneration (IVDD) remains poorly understood. This study aims to elucidate the mechanism by which Drp1 contributes to IVDD and to identify the efficacy of the Drp1 inhibitor Mdivi-1 on IVDD.

Methods: Tert-butyl hydroperoxide (TBHP) is utilized to induce an oxidative stress microenvironment .

Harnessing omics data for drug discovery and development in ovarian aging.

Background: Ovarian aging occurs earlier than the aging of many other organs and has a lasting impact on women's overall health and well-being. However, effective interventions to slow ovarian aging remain limited, primarily due to an incomplete understanding of the underlying molecular mechanisms and drug targets. Recent advances in omics data resources, combined with innovative computational tools, are offering deeper insight into the molecular complexities of ovarian aging, paving the way for new opportunities in drug discovery and development.

Selective urea electrosynthesis nitrate and CO reduction on uncoordinated Zn nanosheets.

Electroreduction of NO and CO to urea (ENCU) represents a fascinating strategy to enable waste NO/CO removal and sustainable urea production. Herein, uncoordinated Zn nanosheets (U-Zn) are developed as a highly selective ENCU catalyst, exhibiting the highest urea-faradaic efficiency of 31.8% with the corresponding urea yield rate of 39.

Dynamic processes of fate decision in inducible bistable systems.

The process of biological fate decision regulated by gene regulatory networks involves numerous complex dynamical interactions among many components. Mathematical modeling typically employed ordinary differential equations and steady-state analysis, which has yielded valuable quantitative insights. However, stable states predicted by theoretical models often fail to capture transient or metastable phenomena that occur during most observation periods in experimental or real biological systems.

Molecular mechanism of proteolytic cleavage-dependent activation of CadC-mediated response to acid in E. coli.

Colonizing in the gastrointestinal tract, Escherichia coli confronts diverse acidic challenges and evolves intricate acid resistance strategies for its survival. The lysine-mediated decarboxylation (Cad) system, featuring lysine decarboxylase CadA, lysine/cadaverine antiporter CadB, and transcriptional activator CadC, plays a crucial role in E. coli's adaptation to moderate acidic stress.

The cAMP receptor protein from Gardnerella vaginalis is not regulated by ligands.

Overgrowth of Gardnerella vaginalis causes an imbalance in vaginal microecology. The pathogenicity of G. vaginalis is directly regulated by the cAMP receptor protein (CRP).

Exosomal lncRNA TUG1 derived from BMSC ameliorate collagen-induced arthritis via BLIMP1-mediated Th17/Treg balance.

Background: Aberrant differentiation of Th17 cells has been identified as a critical factor in the development of rheumatoid arthritis (RA). BLIMP1 plays a key role in regulating plasma cell differentiation, T helper cell differentiation and Treg cell differentiation. Treatment with exosome injection or bone marrow mesenchymal stem cell (BMSC) transplantation reduce joint damage in RA.

Digital economy, resource distortion and low-carbon inclusive development-Evidence from the perspectives of a threshold effect and knowledge spillover effect.

The low-carbon economy represents a global transformation that encompasses production methods, lifestyles, values, national interests, and the destiny of humanity. As a significant contributor to carbon emissions, China has made a momentous strategic decision on carbon peaking and neutralization, infusing momentum into the global effort to address climate change. The rapid growth of the digital economy offers a fresh approach to achieving the "double carbon" objective and advancing the development of low-carbon transformation.

Thermal Effect Management via Entropy Variation Strategy to Improve the Catalyst Stability in Acetylene Hydrogenation.

The dynamic structure evolution of heterogeneous catalysts during reaction has gained great attention recently. However, controllably manipulating dynamic process and then feeding back catalyst design to extend the lifetime remains challenging. Herein, we proposed an entropy variation strategy to develop a dynamic CuZn-Co/HEOs catalyst, in which the non-active Co nano-islands play a crucial role in controlling thermal effect via timely capturing and utilizing reaction heat generated on the adjacent active CuZn alloys, thus solving the deactivation problem of Cu-based catalysts.

Document-level biomedical relation extraction via hierarchical tree graph and relation segmentation module.

Motivation: Biomedical relation extraction at the document level (Bio-DocRE) involves extracting relation instances from biomedical texts that span multiple sentences, often containing various entity concepts such as genes, diseases, chemicals, variants, etc. Currently, this task is usually implemented based on graphs or transformers. However, most work directly models entity features to relation prediction, ignoring the effectiveness of entity pair information as an intermediate state for relation prediction.

Premature Ovarian Insufficiency Is Associated with Increased Risk of Depression, Anxiety, and Poor Life Quality: A Systematic Review and Meta-analysis.

Background: Premature ovarian insufficiency (POI) seriously affects the reproductive health of women. Several studies have been conducted to show that POI appears to be associated with psychological and psychosocial problems, but whether POI increases the risk of mental health problems has not been identified. Therefore, this meta-analysis provides a preliminary systematic assessment of the studies published to date on the impact of POI on women's mental health.

Periostin is associated with prognosis and immune cell infiltration in pancreatic adenocarcinoma based on integrated bioinformatics analysis.

Background: Pancreatic cancer is one of the most aggressive human malignancies. Previous research has shown that periostin (POSTN) promotes pancreatic cancer cell proliferation, migration, and invasion. Further, POSTN is involved in tumor microenvironment remodeling during tumor progression.

The dynamic-process characterization and prediction of synthetic gene circuits by dynamic delay model.

Differential equation models are widely used to describe genetic regulations, predict multicomponent regulatory circuits, and provide quantitative insights. However, it is still challenging to quantitatively link the dynamic behaviors with measured parameters in synthetic circuits. Here, we propose a dynamic delay model (DDM) which includes two simple parts: the dynamic determining part and the doses-related steady-state-determining part.

Electrochemical reduction of nitrite to ammonia on amorphous MoO nanosheets.

Electrocatalytic NO reduction to NH (NORR) is an appealing approach for mitigating NO pollution and for the synthesis of valuable NH, and so the exploration for high-performance NORR catalysts is pivotal yet remains challenging. Herein, amorphous MoO nanosheets (am-MoO) were designed as a high-performance NORR electrocatalyst, delivering a maximum NO-to-NH faradaic efficiency of 94.8% and NH yield rate of 480.