Research progress of PYK2 in digestive system diseases.

Belonging to the focal adhesion kinase (FAK) family, proline-rich tyrosine kinase 2 (PYK2) is a non-receptor tyrosine kinase, has become a focal point in cancer research owing to its essential participation in the formation and dissemination of tumors. Studies have shown that this kinase controls various cellular activities, including: tumor cell adhesion, growth, multiplication, specialization, and detachment, making it a promising target for developing anticancer drugs. The goal of this review is to analyze the multifaceted role of PYK2 in gastrointestinal disease, focusing on its contribution to tumor progression, associated signaling pathways, and the therapeutic potential of PYK2 inhibitors in improving disease management and prognosis.

Efficacy of paliperidone palmitate once-monthly (PP1M) in improving social functioning and reducing caregiver burden in patients with schizophrenia: a six-month follow-up study.

Background: Schizophrenia is a complex chronic mental disorder that severely impairs patients' social functioning and quality of life, while imposing substantial burdens on families and society. Long-acting injectable antipsychotics (LAIs) have demonstrated potential advantages in improving both symptoms and social functioning. This study investigated the effects of transitioning from oral antipsychotics (OAPS) to Paliperidone Palmitate Once-Monthly (PP1M) on symptom control, social functioning, and caregiver burden in schizophrenia patients.

The complex association between bedtime screen use and adult sleep health.

Objectives: To evaluate whether bedtime screen use is associated with sleep health and if this association varies by biological sex, age, and income among adults in Canada.

Methods: Data were collected through a national stratified random population-based phone interview on sleep health among adults (≥18 years) from Canada. Self-reported bedtime screen use (in bed or within 1 hour of bedtime) of the past month was used to classify participants into three groups: occasional ( View Article and Find Full Text PDF

Effect of conditioned stimuli-triggered memory retrieval-extinction in patients with methamphetamine use disorder.

Methamphetamine (METH) is a widely abused stimulant that affects the central nervous system. The persistent maladaptive conditioned stimuli (CS, drug cues)-drug associative memories represent a primary factor precipitating relapse. Interfering with the reconsolidation of these memories may help disrupt and modify these maladaptive CS-drug associations, potentially reducing their influence on drug-seeking behavior.

Stepped-Care Management of Insomnia: Treatment Choices Guided by a Patient Decision Aid in a Pragmatic Nonrandomized Clinical Trial Setting.

Patients with insomnia face difficult decisions when choosing between treatment options with competing risk-benefit profiles. Patient treatment choices were evaluated as part of a pragmatic nonrandomized clinical trial for a two-step cognitive behavioural therapy for insomnia (CBT-I) intervention. Upon enrollment, participants were guided by a patient decision aid (PtDA), outlining the risk-benefit profiles of medication, face-to-face CBT-I (FtFCBT-I), and digital CBT-I (dCBT-I).

Stepped care for insomnia in primary care using digital and face-to-face cognitive behavioral therapies: A pragmatic nonrandomized clinical trial.

Objective: To evaluate the effectiveness of a stepped-care intervention for insomnia in primary care.

Methods: In this non-randomized pragmatic clinical trial, patients from primary care clinics and with chronic insomnia disorder were allowed to choose between continuing their usual treatment (prescribed sleep medication) or receiving digital CBT-I (dCBT-I), either alone or in combination with medication. After the first treatment step, non-remitters were provided with the choice of receiving face-to-face CBT-I (FtFCBT-I), medication, or no additional treatment.

Efficacy of cognitive behavioral therapy for insomnia and lemborexant medication for different subtypes of chronic insomnia: study protocol for a randomized controlled trial.

Introduction: Insomnia is a prevalent yet under-characterized disorder, particularly regarding the heterogeneity of patients and their associated responses to different treatment modalities. This often leads to suboptimal management. There is a need to consider personalized approaches tailored to the characteristics of insomnia phenotypes with regard to objective evidence of shortened sleep duration (< 6 h).

Role of transumbilical laparoendoscopic single-site surgery in the implementation ERAS in gynecology oncology: a retrospective study.

Objective: The aim of the study was to verify the fast recovery effect of transumbilical laparoendoscopic single-site surgery by analyzing the operative and postoperative outcomes of patients with various gynecological malignancies in implementing The Enhanced Recovery After Surgery (ERAS) protocols.

Design: A retrospective study.

Setting: A university academic hospital.

Hydrangea and Lotus Inspired In Situ Growth Mechanism of Nano Basic Copper Acetate on Functional Modified Wood.

The value-added functional modification on wood have attracted much more attention because of global consensus on low carbon and carbon reduction. Nano basic copper acetate is in situ synthesized on a wood surface successfully. The morphology of in situ grown nano basic copper acetate varies according to the wood species and cut wood sections.

Are trajectories of insomnia symptoms associated with clinically significant depressive symptoms or vice versa? Evidence from a 5-year longitudinal study.

Objectives: To examine the association between different insomnia symptom trajectories and subsequent depressive symptoms, as well as the reverse.

Methods: This was a secondary analysis of a population-based study on the natural course of insomnia in Canada, and 3030 participants (18-94 years) with valid data were included. Two separate analyses were conducted for the distinct objectives of the current study, which required different samples.

Exploring the regulatory role of CNPY3 as a prognostic biomarker on human glioma cell migration, invasion and immune infiltration.

BackgroundCanopy FGF signalling regulator 3 (CNPY3) is involved in immune regulation, tumorigenesis and development, nevertheless, its role in glioma remains largely unexplored. Our study aimed to explore the regulatory role of CNPY3 as a prognostic biomarker in human glioma cell migration, invasion and immune infiltration.MethodsBioinformatics analysis of CNPY3 and clinical relevance of glioma in public databases was performed.

The expression of autophagy-related gene CXCL12 in endometriosis associated ovarian cancer and pan-cancer analysis.

Background: Endometriosis-associated ovarian cancer (EAOC), an aggressive form of malignant ovarian neoplasm with origins in endometriosis (EM), has risen to prominence recently. Despite extensive investigation, the precise pathophysiology remains elusive.This article explores new autophagy-related DEG genes between EM and EAOC, and investigates CXCL12's expression and prognostic relevance across pan-cancer.

Message framing materials applied to healthy eating decision-making for pregnant women with gestational diabetes mellitus: An exploratory study.

Aims: To develop and initially validate message framing materials for promoting healthy dietary decisions in GDM populations.

Methods: The Delphi survey involved 17 experts, and consensus was obtained after two rounds. In Pre-survey I, 30 participants randomly selected one material (gain framing vs.

Comparison of robotic and conventional laparoendoscopic single-site hysterectomy for large uterus using da Vinci Xi system: A propensity score matching analysis.

Introduction: The robotic surgical system equipped with enhanced visualization, flexible instruments, tremor filtration, and improved ergonomics can greatly address difficulties encountered in conventional laparoendoscopic single-site surgery. This study aimed to evaluate whether robotic laparoendoscopic single-site surgery performed by da Vinci Xi system was an optimal approach in performing benign hysterectomy for large uterus.

Methods: This was a single-center retrospective cohort study.

Effectiveness of app-based cognitive behavioral therapy for insomnia on preventing major depressive disorder in youth with insomnia and subclinical depression: A randomized clinical trial.

Background: Increasing evidence suggests that insomnia plays an important role in the development of depression, supporting insomnia intervention as a promising approach to prevent depression in youth. This randomized controlled trial evaluated the effectiveness of app-based cognitive behavioral therapy for insomnia (CBT-I) in preventing future onset of major depressive disorder (MDD) in youth.

Methods And Findings: This was a randomized, assessor-blind, parallel group-controlled trial in Chinese youth (aged 15-25 years) with insomnia disorder and subclinical depressive symptoms.

Advancing adolescent bedtime by motivational interviewing and text message: a randomized controlled trial.

Background: Sleep deprivation is a prevalent problem among adolescents which is closely related to various adverse outcomes. The lack of efficacy of current sleep education programs among adolescents argues for the need to refine the content and format of the intervention. This study aimed to evaluate the effectiveness of a group-based sleep intervention using motivational interviewing plus text reminders in changing adolescent sleep habits.

Nanomaterials at the forefront of antimicrobial therapy by photodynamic and photothermal strategies.

In the face of the increasing resistance of microorganisms to traditional antibiotics, the development of innovative treatment methods is becoming increasingly urgent. Nanophototherapy technology can precisely target the infected area and achieve synergistic antibacterial effects in multiple modes. This phototherapy method has shown significant efficacy in treating diseases caused by drug-resistant bacteria, especially in the elimination of biofilms, where it has demonstrated strong dissolution capabilities.

transmission electron microscopy insights into nanoscale deformation mechanisms of body-centered cubic metals.

Nanostructured body-centered cubic (BCC) metals exhibit remarkable mechanical properties under various stress fields, making them promising candidates for novel micro/nanoelectromechanical systems (M/NEMS). A deep understanding of their mechanical behaviors, particularly at the atomic scale, is essential for optimizing their properties and expanding their applications at the nanoscale. Newly developed nanomechanical testing techniques within transmission electron microscopy (TEM) provide powerful tools for uncovering the atomic-scale microstructural evolution of nanostructured BCC materials under external forces.

Dynamic processes of fate decision in inducible bistable systems.

The process of biological fate decision regulated by gene regulatory networks involves numerous complex dynamical interactions among many components. Mathematical modeling typically employed ordinary differential equations and steady-state analysis, which has yielded valuable quantitative insights. However, stable states predicted by theoretical models often fail to capture transient or metastable phenomena that occur during most observation periods in experimental or real biological systems.

Perceived economic inequality inhibits pro-environmental engagement.

We currently inhabit an era marked by increasing economic inequality. This paper delves into the repercussions of perceived economic inequality on individual-level pro-environmental engagement and puts forth an explanatory mechanism. Across three empirical studies encompassing an archival investigation employing a nationally representative data set (Study 1), an online survey (Study 2) and an in-lab experiment (Study 3), we consistently unearth the inhibiting effect of perceived economic inequality on individuals' pro-environmental involvement, whether assessed through pro-environmental intentions or behaviours.