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http://dx.doi.org/10.4103/ija.ija_1147_24 | DOI Listing |
Mol Pharm
September 2025
Department of Biochemical Engineering, University College London, Gower Street, London, WC1E 6BT, U.K.
We built a custom device to subject an antibody fragment A33 Fab to controlled stress conditions that combined pH, temperature, agitation, and LED-based light exposure in polypropylene microplates; to simulate the real-world challenges it may encounter during storage and transportation and to evaluate the key degradation routes in Fab formulations. We also explored the addition of Tween 80 as a surfactant and the impact of plate surface siliconisation. Monomer loss and fragmentation was monitored by size-exclusion chromatography, aggregate formation determined by changes in hydrodynamic radius in DLS, and chemical modifications identified through intact mass analysis by LC-MS, and N-terminal sequencing.
View Article and Find Full Text PDFFront Plant Sci
August 2025
Fruit Research Institute, Čačak, Serbia.
The Balkan Peninsula is a European biodiversity hotspot, home to 6,500 native vascular plant species, many of which are endemic. The region has diverse range of climates and complex topography, creating conditions that suit many woody ornamental, fruit, and forest species. Nevertheless, climate change, habitat destruction, invasive species, plant diseases, and agricultural practices threaten natural ecosystems and cultivated species.
View Article and Find Full Text PDFGlob Health Action
December 2025
Department of Otolaryngology, Head & Neck Surgery, Shanxi Medical University Second Affiliated Hospital, Taiyuan, Shanxi Province, China.
Background: Allergic rhinitis (AR) is an increasingly prominent global public health issue, where air pollution significantly contributes to its rising incidence. Although numerous studies have explored the link between air pollution and AR pathogenesis, comprehensive summaries are still limited.
Objective: This study performs a bibliometric analysis to identify research hotspots and emerging trends, offering insights into AR prevention and management.
J Colloid Interface Sci
August 2025
School of Chemistry, Dalian University of Technology, Dalian 116024, PR China; College of Environment and Chemical Engineering, Dalian University, Dalian 116622, China. Electronic address:
Aqueous batteries have become a prospective future energy storage system because of their low coefficient of cost and stability. However, their lower energy density limits their applications. Ammonium ions (NH) have a small hydration radius and light molar mass, and aqueous ammonium ion batteries (AAIBs) are anticipated for solving the inherent low-energy density problem of aqueous batteries.
View Article and Find Full Text PDFmBio
September 2025
Department of Biology, Laboratory of Molecular Cell Biology, KU Leuven, Leuven, Flanders, Belgium.
Echinocandins, which target the fungal β-1,3-glucan synthase (Fks), are essential for treating invasive fungal infections, yet resistance is increasingly reported. While resistance typically arises through mutations in Fks hotspots, emerging evidence suggests a contributing role of changes in membrane sterol composition due to mutations. Here, we present a clinical case of () in which combined mutations in and , but not alone, appear to confer echinocandin resistance.
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