Diagnostics and immunological function of CENPN in human tumors: from pan-cancer analysis to validation in breast cancer.

Background: Centromere protein N (), a member of the centromere protein family, contributes to ribonucleic assembly, mitosis progression, and chromosome separation. manifests a close link with the occurrence and progression of several malignant cancers, but there is no pan-cancer study on , and we aim to ascertain the connection between and human cancer prognosis and immunotherapy.

Methods: The function in multiple malignant tumors was comprehensively investigated with data from The Cancer Genome Atlas (TCGA) and integrated Gene Expression Omnibus (GEO) database.

Diagnostic value of 5 miRNAs combined detection for breast cancer.

Background: Breast cancer (BC) is the prevailing malignant tumor, with its prevalence and death rate steadily rising over time. BC often does not show obvious symptoms in its early stages and is difficult to distinguish from benign breast disease. We aimed to find a distinct group of miRNAs utilizing serum as a non-invasive biomarker for early BC diagnosis.