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Background: Prostatectomy frequently leads to postoperative urinary incontinence (UI), significantly impairing patients' quality of life. While pelvic floor muscle exercises (PFME) are commonly employed, the efficacy of electrical stimulation (ES) as a non-invasive adjunct remains debated. This systematic review and meta-analysis evaluated the effectiveness of ES combined with PFME versus PFME alone for post-radical prostatectomy UI.
Method: A comprehensive search across PubMed, MEDLINE, EMBASE, Cochrane Library, and ResearchGate identified 10 randomized controlled trials (RCTs) meeting inclusion criteria. Outcomes included 24-hour pad test, International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF), quality of life (QOL), and incontinence control rate. Data were analyzed using Review Manager 5.4.1, employing fixed- and random-effects models.
Results: Short-term ES (≤3 months) significantly improved ICIQ-SF scores (MD = - 3.50; 95% CI: - 5.11 to -1.89, p < 0.0001) and doubled incontinence control rates (RR = 2.01; p = 0.01), though no improvement was observed in 24-hour pad test (MD = - 50.07; p = 0.30) or QOL. Conversely, long-term ES (≥6 months) demonstrated marked reductions in urinary leakage via the 24-hour pad test (MD = - 21.64; p = 0.02), but no significant differences in ICIQ-SF scores or control rates compared to PFME alone.
Conclusion: Electrical stimulation therapy can be an effective treatment option for patients with post-RP UI. It can significantly improve UI symptoms in the short term and has a positive impact on reducing urinary leakage in the long term.
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http://dx.doi.org/10.1097/JS9.0000000000002685 | DOI Listing |
Toxicon
September 2025
Departamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil. Electronic address:
Lithobates palmipes is a frog species whose skin secretions contain peptides belonging to the ranatuerin, brevinin, and temporin families. In this study, the peptide ranatuerin-2PMe was isolated and evaluated for its antimicrobial, hemolytic, antiproliferative, and chemotactic activities. Ranatuerin-2PMe (2933.
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August 2025
Department of Psychology, University of Amsterdam, Amsterdam, the Netherlands.
Crossmodal correspondences - systematic mappings between stimulus attributes in different modalities - are ubiquitous in the general population. For example, high-pitched (vs low-pitched) sounds are commonly associated with elevated (vs low) positions in space, and rounded (vs angular) shapes tend to be linked to the term 'Bouba' (vs 'Kiki'). There is still some debate about the role of immediate sensory experience versus conceptual colour understanding in crossmodal correspondences.
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Institute of Pharmacology and Toxicology, School of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany; Einstein Center for Neurosciences (ECN), Charité - Universitätsmedizin Berlin, Germany. Electronic address:
Reactive astrogliosis and microgliosis are hallmarks of various central nervous system (CNS) diseases, including epilepsy. Both are observed following seizures in various models of epilepsy. We conducted a systematic meta-analysis to synthesize current knowledge on reactive astrogliosis and microgliosis in animal models involving experimentally induced seizures using a multilevel approach to analyze 260 comparisons from 52 studies.
View Article and Find Full Text PDFInt Immunopharmacol
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Key Laboratory of Anesthesia and Intensive Care Research, Harbin, China; Department of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address:
Aims: Intestinal ischemia-reperfusion (II/R) injury predominantly causes acute lung injury (ALI), and in severe instances, acute respiratory distress syndrome, both associated with high mortality. Electroacupuncture (EA) excels in regulating autonomic nervous system balance and safeguarding organ function. This study delved into EA's impacts and mechanisms on II/R-induced ALI.
View Article and Find Full Text PDFActa Neurochir (Wien)
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Gui de Chauliac Hospital, Montpellier University Medical Center, Montpellier, France.
Background: Awake surgery is the reference for diffuse low-grade glioma resection, allowing maximal tumor removal while preserving neurocognitive functions. It is also applicable to other brain tumors. However, key technical elements must be followed to ensure optimal conditions for intraoperative cognitive testing and reliable functional mapping.
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