A benzothiazole derivative-based turn-on fluorescent probe for specific detection of Cys.

Cysteine (Cys) is a core biological thiol that regulates cellular redox homeostasis. Abnormal concentrations of Cys are closely related to tumorigenesis, neurodegenerative diseases, and metabolic disorders, and are often used as biomarkers for cancer cells. Therefore, detecting and analyzing its levels in the microenvironment of cancer cells is important.

Detection of HO by a novel fluorescent probe based on the synergy of "ESIPT + ICT".

Hydrogen peroxide plays a crucial role in maintaining physiological homeostasis in the human body, so it is imperative to design a highly selective and sensitive fluorescent probe to monitor the content of HO in organisms. Herein, we designed a probe with benzothiazole (HBT) as the main fluorophore backbone, which realized the molecular "ESIPT + ICT" synergistic luminescence effect. An effective response to detect HO within 30 min was achieved by the probe HBT-B, with a detection limit of 1.

Effect of on metabolites in over-expressed and wild-type tomato fruit.

Background: Tomato () is an annual or perennial herb that occupies an important position in daily agricultural production. It is an essential food crop for humans and its ripening process is regulated by a number of genes. S-adenosyl-l-homocysteine hydrolase (AdoHcyase, EC 3.

Moderate mechanical stress suppresses chondrocyte ferroptosis in osteoarthritis by regulating NF-κB p65/GPX4 signaling pathway.

Ferroptosis is a recently identified form of programmed cell death that plays an important role in the pathophysiological process of osteoarthritis (OA). Herein, we investigated the protective effect of moderate mechanical stress on chondrocyte ferroptosis and further revealed the internal molecular mechanism. Intra-articular injection of sodium iodoacetate (MIA) was conducted to induce the rat model of OA in vivo, meanwhile, interleukin-1 beta (IL-1β) was treated to chondrocytes to induce the OA cell model in vitro.

XT-considered multiple backup paths and resources shared protection scheme based on ring covers.

With the rapid development of space division multiplexing (SDM) and flexible grid technology, the problem of resource allocation in optical network becomes much more complicated. Although there emerge a substantial number of works about link protection or restoration in SDM-EONs mesh networks, the topic of survivability is dug deeper in this work. It is acknowledged that protection schemes based on ring covers bring the advantages of shorter restoration time and lower costs.

Evaluation of the ability of black nightshade Solanum nigrum L. for phytoremediation of thallium-contaminated soil.

Thallium (Tl) pollution in agricultural areas can pose hidden danger to humans, as food consumption is the key exposure pathway of Tl. Owing to the extreme toxicity of Tl, removal of Tl from soil becomes necessary to minimize the Tl-related health effects. Phytoremediation is a cost-effective method to remove heavy metals from soil, but not all plants are appropriate for this purpose.