Phytochemical Screening and Antidiabetic Potential of in Alloxan-Induced Diabetic Rats: Investigative Study Toward Possible Mechanism.

has long been used in folk medicine to treat a variety of ailments, including diabetes, skin disorders, dropsy, cuts, wounds, ulcers, fever, and blood disorders, etc., which are generally categorized under the complications of diabetes mellitus. Various species of this genus have also been verified to possess strong anti-diabetic activity.

Correction: Mahnashi et al. In-Vitro, In-Vivo, Molecular Docking and ADMET Studies of 2-Substituted 3,7-Dihydroxy-4H-chromen-4-one for Oxidative Stress, Inflammation and Alzheimer's Disease. 2022, , 1055.

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Phytochemical Profiling and Dual In Vitro In Vivo Antidiabetic Assessment of Ethyl Acetate Fraction and Essential Oil From Allium ascalonicum.

Allium ascalonicum (shallot) is a traditional medicinal plant recognized for its rich phytochemical content and therapeutic potential. This study aimed to evaluate the phytochemical composition, antidiabetic activity, and toxicity profile of the ethyl acetate fraction and essential oil. GC-MS analysis identified 34 compounds in the ethyl acetate fraction, with major constituents including phenol, 2-methoxy-4-vinyl- (17.

Phytochemical Profiling and Bioactive Potential of Rhizoclonium hookeri, Antioxidant, Antidiabetic, and Neuroprotective Effects.

During the past two decades, algal-derived chemical constituents have garnered considerable attention, particularly for their pharmaceutical and nutraceutical applications. In this study, the phytochemical composition of the freshwater alga Rhizoclonium hookeri was investigated, alongside an evaluation of its pharmacological potential. Results of the study revealed that the total phenolic content (TPC) and total flavonoid content (TFC) were found to be higher in n-butanol compared to DCM extract.

Lemongrass Alleviates Primary Dysmenorrhea Symptoms by Reducing Oxidative Stress and Inflammation and Relaxing the Uterine Muscles.

Primary dysmenorrhea (PD) is characterized by lower abdominal spasms and painful cramps during menstruation in females with a normal pelvic anatomy. (DC.) Stapf, commonly known as lemongrass, is consumed in the form of herbal tea around the world.

Assessment of Preclinical Antioxidative and Anti-Inflammatory Activities of Wall. Bark.

Wall. Bark has been traditionally utilized for its therapeutic properties; however, limited scientific evidence is available that supports its role as having anti-inflammatory and neuroprotective properties. Exploring the neuroprotective and anti-inflammatory properties of Wall.

Design, Synthesis, SwissADME Profile DFT Studies, in vitro and in silico Anti-diabetic Potential of Novel Amide Derivatives Based on Bis((4-amino-4-oxobutanoyl)oxy) Zinc Scaffold.

Aims: Synthesis and in silico therapeutic potential of newly synthesized amide derivatives based on bis((4-amino-4-oxobutanoyl)oxy)zinc scaffold and their antidiabetic potential.

Background: Indeed, the design and synthesis of coordinated complexes are gaining substantial attention in synthetic chemistry due to their intriguing structures and possible applications in catalysis, molecular magnetism, and biological potentials.

Objective: The current study deals with the synthesis of amide derivatives based on bis((4-amino-4- oxobutanoyl)oxy)zinc scaffold C1-C5 followed by Swiss absorption, distribution, metabolism, and elimination (ADME), Density functional theory (DFT) studies, molecular docking and in vitro antidiabetic activity.

and computational experiments for the antidiabetic potential of bioactive compound from .

Diabetes mellitus is a prevalent condition that significantly impacts the lifestyles of a large portion of the global population. This study aims to explore the efficacy of isolated compound from in the treatment of diabetes mellitus. The compound, 2-veratryl-3,7-dihydroxy-4-one () analogue, an isolated bioactive from is now evaluated for its α-glucosidase and α-amylase activities.

An Insight Into the Phytochemical Composition, Cardioprotective, and Antioxidant Characteristics of Small Knotweed ( R. Br.) Extract and Its Derived Fractions.

, a member of the Polygonaceae family, is commonly known as small knotweed and has been traditionally used to treat various ailments, including cough, gastrointestinal disorders, respiratory infections, liver disease, inflammation, dysentery, eczema and ringworms, and other skin conditions. Many studies have suggested that plants belonging to this genus possess strong cardio-protective potentials. Rats were pre-treated with crude methanolic extract and other fractions at a dose of 500 mg/kg followed by administration of Isoproterenol hydrochloride after 24 h for 2 days.

Antileishmanial potential of thiourea-based derivatives: design, synthesis and biological activity.

Leishmaniasis is a neglected tropical disease caused by protozoan parasites and transmitted to humans by the sandfly vector. Currently, the disease has limited therapeutic alternatives. Thiourea derivatives were designed, synthesized, and screened for antileishmanial activity.

Discovery of the selective and nanomolar inhibitor of DPP-4 more potent than sitagliptin by structure-guided rational design.

Various therapeutic targets and approaches are commonly employed in the management of Type 2 Diabetes. These encompass diverse groups of drugs that target different mechanisms involved in glucose regulation. Inhibition of the DPP-4 enzyme has been proven an excellent target for antidiabetic drug design.

Pharmacological evaluation and binding behavior of 4,4'-diamino-2,2'-stilbene disulfonic acid with metal ions using spectroscopic techniques.

Industrial and human activities contribute significantly to the environmental contamination of heavy metal ions (HMIs), which have detrimental effects on aquatic life, plants, and animals, causing major toxicological problems. The commercially available has been playing a vital role in the detection of heavy metal ions and has significantly inhibited a variety of cancer cells in numerous field of modern science. The current investigation aimed to ensure the detection of heavy metals ions from the environment and fluorescence imaging of DSD in the treatment of cancer cells.

Anti-Diabetic, Anti-Cholinesterase, and Anti-Inflammatory Potential of Plant Derived Extracts and Column Semi-Purified Fractions of .

Background: The present study aimed to investigate the anti-diabetic, anti-cholinesterase, and anti-inflammatory potential of extracts from different parts of , including leaves, stem, and roots, as well as isolated column fractions (F-B-1 C, F-B-2 C, F-B-3 C, and F-B-4 C).

Methods: The extracts and subsequent fractions were evaluated for their inhibitory activity against key enzymes involved in diabetes [α-glucosidase and α-amylase], neurodegenerative diseases [acetylcholinesterase and butyrylcholinesterase], and inflammation (cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX)).

Results: The results showed that leaf extract exhibited the highest α-glucosidase inhibitory activity (73.

Hypoglycemic, anti-inflammatory, and neuroprotective potentials of crude methanolic extract from L. - results of an in vitro study.

L., also known as babul, belonging to the Fabaceae family and the genus, is typically used for ornamental purposes and also as a medicinal plant found in tropical and subtropical areas. This plant is a rich source of bioactive compounds.

Exploitation of the multitarget role of new ferulic and gallic acid derivatives in oxidative stress-related Alzheimer's disease therapies: design, synthesis and bioevaluation.

Monoamine oxidases (MAOs) inhibitors could decrease reactive oxygen species (ROS) generation, enhance mono-aminergic neural transmission, and have major therapeutic benefits for the treatment of Alzheimer's disease (AD). Following the conjunction of ferulic acid (FA)/gallic acid (GA) with sulfonamide, alanine and 2-aminobenzothiazole, we planned to assess the radical scavenging and antioxidant properties of synthesized analogs by using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and ferric ion reducing antioxidant power (FRAP) assays. GA analog 28 was identified as the most potent antioxidant compound with IC values of 1.

Modification of 4-(4-chlorothiophen-2-yl)thiazol-2-amine derivatives for the treatment of analgesia and inflammation: synthesis and , , and studies.

Inflammation is a protective response to a variety of infectious agents. To develop a new anti-inflammatory drug, we explored a pharmacologically important thiazole scaffold in this study. In a multi-step synthetic approach, we synthesized seven new thiazole derivatives (-).

Phenolic phytochemistry, , , , and mechanistic anti-inflammatory and antioxidant evaluations of .

Excessive and imbalance of free radicals within the body lead to inflammation. The objective of the current research work was to explore the anti-inflammatory and antioxidant potential of the isolated compounds from In this study, the isolated phenolic compounds were investigated for and anti-inflammatory potential along with the antioxidant enzyme. The anti-inflammatory and antioxidant potential of the phenolic compounds was assayed via various enzymes like COX-1/2, 5-LOX and ABTS, DPPH, and HO free radical enzyme inhibitory assay.

Antioxidant, carbonic anhydrase inhibition and diuretic activity of Forssk. Decne.

Background: Forssk. Decne is a member of family Apocynaceae and locally known as 'Khipp'. It is found in dry, sandy habitat of Pakistan and in several other regions around the world including Asia, Tropical Africa, Western Gulf and Mediterranean countries.

Novel Coumarin Derivatives as Potential Urease Inhibitors for Kidney Stone Prevention and Antiulcer Therapy: From Synthesis to In Vivo Evaluation.

The presence of ammonium ions in urine, along with basic pH in the presence of urease-producing bacteria, promotes the production of struvite stones. This causes renal malfunction, which is manifested by symptoms such as fever, nausea, vomiting, and blood in the urine. The involvement of urease in stone formation makes it a good target for finding urease enzyme inhibitors, which have the potential to be developed as lead drugs against kidney stones in the future.

2-Hydroxybenzohydrazide as a novel potential candidate against nociception, inflammation, and pyrexia: in vitro, in vivo, and computational approaches.

The current study was designed to evaluate the 2-hydroxybenzohydrazide (HBH) as a drug having efficacy against pyrexia, inflammation, and nociception. Besides, the therapeutic effects of HBH on oxidative stress and C-reactive proteins were also evaluated. The pharmacological studies on HBH (20-60 mg/kg) were conducted using nociception, inflammation, and pyrexia standard models.

Synthesis, inhibition of cyclooxygenases and studies of new isoxazole derivatives.

Isoxazole belongs to the class of five-membered heterocyclic compounds. The process of developing new drugs has significantly gained attention due to inadequate pharmacokinetic and safety attributes of the available drugs. This study aimed to design a new diverse array of ten novel isoxazole derivatives via Claisen Schmidt condensation reaction.