Cardiomyocyte regeneration therapy and its effect on LVEF and scar size- a systematic review and meta-analysis.

Background: Myocardial infarction (MI) results in loss of cardiomyocytes leading to heart failure. Despite advancements in pharmacotherapy and interventions such as revascularization, ischemic heart failure remains a challenge. Recent advancements in stem cell therapies, genetic engineering and bioengineering have shown to improve cardiac function and quality of life.

Pollution indices of brackish water and sediments of major mangrove sites along Arabian Sea coast of Pakistan.

Heavy metal (HM) contamination poses a significant environmental threat to Mangrove ecosystems, particularly in industrial and urban-influenced regions. This study has investigated the spatial and seasonal distribution of HM in water and sediment samples from three major mangrove sites along the Arabian Sea coast of Pakistan, Indus Delta, Sandspit and Miani Hor. Ten heavy metals (HM)- aluminum (Al), arsenic (Ar), cadmium (Cd), chromium (Cr), copper (Cu), iron (Fe), lead (Pb), mercury (Hg), selenium (Se), and zinc (Zn) were assessed using multiple pollution indices to evaluate the contamination levels and ecological risks.

Synthesis, Spectroscopic, Electronic and Molecular Docking Studies of Pyrazole Based Chalcones as Potential Anticancer Agents.

A series of pyrazole-based chalcone derivatives (DF1-DF6) were synthesized and characterized using spectroscopic (H/C NMR, FT-IR) and computational methods. NMR analysis in acetone-d revealed aromatic protons (7.0-8.

MangoImageBD: An extensive mango image dataset for identification and classification of various mango varieties in Bangladesh.

The mango image dataset presented in this article contains clear and detailed images of the fifteen most common and popular mango () varieties in Bangladesh: Amrapali, Ashshina Classic, Ashshina Zhinuk, Banana Mango, Bari-4, Bari-11, Fazli Classic, Fazli Shurmai, Gourmoti, Harivanga, Himsagor, Katimon, Langra, Rupali, and Shada. The mango specimens were sourced from various fruit markets across six districts of Bangladesh, namely Rajshahi, Chapai Nawabganj, Satkhira, Panchagarh, Rangpur, and Dhaka, which are famous for popular mango cultivation and availability to ensure a wide geographic representation. To maintain the quality and uniformity of images across the dataset, the images were captured using a high-definition smartphone camera under a standardized and controlled environment.

MicroRNA Expression and Neurocognitive Outcomes in Children and Young People With Primary Brain Tumor in Karachi, Pakistan: A Pilot Exploratory Study.

Background: microRNAs regulate various cellular pathways and may serve as medium-term prognostic markers in neurocognitive function, as suggested by adult studies. However, no comparable data exist for children with central nervous system tumors. This pilot study explored miRNA expression and its correlation with 12-month posttreatment neurocognitive function in children and young adults (5-21 years) with primary brain tumors.

The Role of Artificial Intelligence in Heart Failure Diagnostics, Risk Prediction, and Therapeutic Strategies: A Comprehensive Review.

Heart failure (HF) is a prevalent global health concern, impacting millions and contributing to high morbidity, mortality, and healthcare costs. The management of HF involves complex strategies, and traditional approaches often fail to address the escalating burden of hospital readmissions and deteriorating patient quality of life. Artificial intelligence (AI) has emerged as a promising tool for enhancing diagnostic accuracy, personalizing treatment plans, and improving patient outcomes in HF care.

Decoding the Molecular Mechanism of Bioactive Compounds Derived from Microalgae via Transcriptomics Data and Integrative Bioinformatics Analysis.

Introduction: Microalgae, with their high photosynthetic efficiency and sustainability, hold promise to produce bioactive compounds, chemicals, cosmetics, and biofuels. This study aims to understand the molecular mechanisms of bioactive compounds from microalgae using integrative bioinformatics approaches to identify their potential therapeutic applications.

Methods: Gene expression profiles from the GSE113144 and GSE115827 datasets were retrieved from the GEO database using keywords such as liver disease, microalgae, and bioactive compounds.

Zirconium-based MOFs as pH-responsive drug delivery systems: encapsulation and release profiles of ciprofloxacin.

As antimicrobial resistance (AMR) continues to rise, the need for improved antibiotic delivery systems is urgent to prevent overexposure from systemic administration. To address this clinical trial, metal-organic frameworks have developed as promising contender for regulated drug release. In this study, ciprofloxacin (CIP) was encapsulated into two zirconium-based MOFs (ZrMOF-1 and Zr-MOF-2), synthesized a previously reported solvothermal method.

Reservoir water-level operations to manage biogeochemical turnover.

Rapid decrease in temperature changes water stratification structure into an unstable state, reinforcing water convection and enhancing vertical biogeochemical fluxes, which might pose a threat to aquatic ecosystems, especially for drinking water use. At high latitudes, current research predominantly focuses on destratification systems to reduce the degradation of aquatic ecosystems. However, at low latitudes, the strategies of enhanced stratification through water level operation (WLO) provide a perspective for reservoir management.

Dissenting an Uncommon Diagnosis at Unusual Origin: A Case Report of Teratocarcinosarcoma of Sinonasal Cavity - A Rare Malignancy.

Introduction: Teratocarcinosarcoma is an extremely rare and aggressive malignancy of the nasal cavity and paranasal sinuses, comprising epithelial, mesenchymal, and neuroectodermal components. Due to its aggressive behavior, early diagnosis and a multimodal treatment approach are essential for improving outcomes.

Case Presentation: We report the case of a 55-year-old male who presented with bilateral nasal discharge, recurrent epistaxis, progressive nasal swelling, and left-sided epiphora over several months.

The Role of N-terminal Pro-B-Type Natriuretic Peptide, Troponins, and D-dimer in Acute Cardio-Respiratory Syndromes: A Multi-specialty Systematic Review.

This systematic review evaluates the diagnostic and prognostic utility of N-terminal pro-B-type natriuretic peptide (NT-proBNP), cardiac troponins, and D-dimer in acute cardio-respiratory syndromes, including heart failure (HF), acute coronary syndrome (ACS), pulmonary embolism (PE), acute respiratory distress syndrome (ARDS), and coronavirus disease 2019 (COVID-19)-related complications. These biomarkers play critical roles in assessing myocardial stress, injury, and thrombosis risk, offering a rapid and cost-effective alternative to traditional diagnostic tools. A comprehensive literature search from 2015 to 2024 identified 14 high-quality studies, demonstrating NT-proBNP's strong correlation with HF severity and mortality risk in severe COVID-19, while cardiac troponins were associated with myocardial injury in ARDS and ACS.

Optimizing waste valorization: catalytic co-pyrolysis of cabbage waste and tire waste for enhanced bio-oil and syngas production utilizing char as a reforming catalyst.

This study explores the catalytic co-pyrolysis of cabbage waste (CW) and tire waste (TW) to enhance the yield and quality of bio-oil and syngas. Although CW is produced in large quantities from global cabbage cultivation, its lower hydrogen content limits its utility for fuel and chemical production. The co-pyrolysis process, utilizing char as a catalyst, presents a cost-effective approach to optimize product outputs by promoting the reforming of volatiles during thermal decomposition.

Outcomes after Cortical Bone Trajectory Screw versus Traditional Pedicle Screw in Single-Level Lumbar Spine Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Background: Cortical bone trajectory screw (CBTS) is reported to offer increased cortical bone purchase and improved outcomes as compared to the traditional pedicle screw (PS), particularly in osteoporotic patients. The systematic review aims to compare randomized controlled trials comparing CBTS with PS in single-level lumbar spine fusion surgery.

Methods: A systematic search was conducted on PubMed (MEDLINE), Scopus, Embase, Web of Science, and Cochrane.

Quantum Chemical Insights into Metal-Ion Enhanced NLO Response of a Fluorescent Probe for Advanced Sensing Application.

High-performance nonlinear optical (NLO) materials are essential for optoelectronic and sensing technologies, yet multifunctional systems combining fluorescence and NLO properties remain scarce. Through systematic computational analysis, we investigate 4-chloro-2-(1-phenylimidazo[1,5-a]pyridin-3-yl)phenol (IUB) complexes with strategically selected metals: alkali (Li⁺, Na⁺, K⁺) and alkaline earth (Mg, Ca) ions to probe charge/size effects, and transition metals (Ni, Zn) as contrasting d-block representatives, Ni for its paramagnetic fluorescence quenching and Zn for its closed-shell fluorescence preservation. This selection enables direct comparison of how electronic configuration (s/p-block vs d-block) and oxidation state (+ 1 vs + 2) governs optoelectronic properties.

Exploring the role of H-migration in the aromaticity, spectroscopic, photovoltaic and optical properties of planar heterocyclic compounds: a DFT study.

In this study, five tautomer's IB1-IB5 are designed and studied, containing donor (-NH)-π(THDP)-acceptor (-NO) frameworks, formed through the migration of hydrogen atoms from/to the pyrazine rings. The designed and theoretically explored compounds IB2 and IB5 originate from double-hydrogen migration, while IB3 and IB4 are derived by single-hydrogen migration from adjacent pyrazine rings of IB1. Extensive DFT studies were conducted to explore the aromatic behavior, stability, reactivity, natural bond orbitals (NBOs), polarizabilities, and absorption behavior to investigate the effect of electron localization.

Unintended pregnancies: a comprehensive cost-benefit analysis of family planning investment in Pakistan.

Introduction: Unintended pregnancies, which account for 19.4 to 38.2% of all births, present a significant and pressing public health challenge in Pakistan.

The nematicidal potential of extracts and rhizobacteria against in tomato.

Here we report the effects of aqueous extracts of the plant and rhizobacterial strains, (BA-LWD73) and (BT-WAG41), applied singly and in combination, on tomato growth and infection. Plant height, root length, shoot and root biomass (fresh and dry), were significantly increased by most treatments compared to the control. The combined treatment of BA-LWD73 + produced the highest plant height (96.

Green synthesis an eco-friendly route for the synthesis of iron oxide nanoparticles using aqueous extract of Thevetia peruviana and their biological activities.

This study reports the plant extract-assisted synthesis of iron oxide (FeO) using the aqueous extract of Thevetia peruviana. The synthesized IONPs were confirmed via UV-Vis spectroscopy (295 nm) and characterized using FTIR and SEM. Density Functional Theory (DFT) calculations indicated a thermodynamically and mechanically stable system with semimetallic behavior and visible light absorption.