A scoping review on the possible immunometabolic properties of the furan fatty acid metabolite 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid.

Circulating levels of 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid (CMPF), a metabolite derived from dietary furan fatty acids primarily found in marine food sources, have long been recognized as biomarkers for fish intake. However, elevated CMPF levels are also observed in patients with type 2 diabetes or chronic kidney disease and in healthy people associated with a reduced infection risk, suggesting potential bioactive roles in metabolism and immune function. Yet, the possible causal mechanisms behind these associations are unknown.

Scalable Acid-Aided Lysis of Skin Samples Improves Proteome Coverage.

Liquid chromatography-mass spectrometry (LC-MS) is an evolving tool for comprehensive proteomic analyses across tissues. Despite the widespread use of LC-MS in dermatology, full-thickness human skin remains challenging to analyse. The skin extracellular matrix (ECM) presents two major obstacles: the extensive crosslinking complicates protein extraction and the high abundance of ECM proteins can mask lower-abundance proteins, reducing identification numbers.

The influence of autoinjector applied force and shield size on abdominal skin and subcutaneous tissue deformation - An in-vivo ultrasound and digital image correlation study.

Background: Shield-triggered autoinjectors (AIs) aim to reduce needle phobia and accidental needlestick injuries and improve usability. However, they may cause deeper injections due to tissue compression. This study investigates the mechanical response of AI application into abdominal tissue in-vivo.

Ovarian reserve markers in women of reproductive ages with epilepsy.

Objective: The objective of this study was to examine ovarian reserve parameters in women with epilepsy compared to women without epilepsy.

Methods: A total of 80 women with epilepsy (WWE) from the epilepsy clinic at Rigshospitalet, Denmark, participated and completed the study between 2018-2022. A historical cohort collected from 2008 to 2010 of 418 women without epilepsy and no prior diagnosis of infertility was used as control.

Distributed Response to Distributed Intervening: Making Sense of Public Digitalization Through Digital Support.

Communication and interaction with public authorities and healthcare professionals in Denmark primarily go through digital self-service platforms, requiring diverse skills and device access. In this article, we describe how senior citizens in Denmark handle and make sense of public digitalization through different forms of digital support. Through an ethnographic study of community-led initiatives of digital support, we highlight how senior citizens find socio-technical ways of managing digital obligations and argue that citizens' digital agency in day-to-day interactions with public digitalization relies heavily on distributed socio-material relations.

Unbroken -symmetry in the absence of gain or loss.

The concept of parity-time symmetry has firmly established non-Hermiticity as a versatile degree of freedom on a variety of physical platforms. In general, the non-Hermitian dynamics of open systems are perceived to be inextricably linked to complex-valued potentials facilitating the local attenuation and coherent amplification in wave mechanics. Along these lines, time reversal symmetry is associated with a complex conjugation of the potential landscape, in essence swapping gain and loss.

Unravelling the mechanism of enzymatic resistance in different high amylose starch granules.

This study investigates the phenomenon that, in contrast to amylopectin-rich starch granules, high amylose starch (HAS) granules typically exhibit high hydrolytic resistance manifested as low density of enzyme attack sites on the starch granule surface. However, among the various types of examined HAS granules, we identified differences in enzymatic resistance. We associated this effect as a result of variations in specific rate of the enzymatic reaction, with intermediate affinity leading to the highest enzymatic efficacy characteristic for the Sabatier principle.

TLR5 influences the development of type 1 diabetes.

Unlabelled: In mammalian and human life, it is important that the immune system defends against microorganisms. Although there is a huge overlap, innate cells are good against bacteria, whereas T cells are good against viruses, mainly because of antibody production via T helper and B lymphocytes. Toll-like receptor 5 (TLR5) is a regulator; when it is highly expressed, T cells are inhibited, and innate cells are favored.

Internalizing and externalizing symptoms and prosocial behavior and pubertal timing in boys and girls: A cohort study.

Purpose: To study the association between internalizing and externalizing symptoms and prosocial behavior at age 7 years and pubertal timing in boys and girls.

Methods: This cohort study included 11,090 children from the Puberty Cohort within the Danish National Birth Cohort (DNBC). Data on internalizing and externalizing symptoms and prosocial behavior was derived from a parent-reported Strengths and Difficulties Questionnaire (SDQ) at age 7 years, and categorized as normal (lowest 79th percent), at-risk (80th - 89th percent) or abnormal (≥90th percent).

Early surgical complications following kidney transplantation in adults: A systematic review.

Objective: To quantify and characterise short-term (<90 days) surgical complications following kidney transplantation and identify risk factors for complications.

Methods: This systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and the protocol registered with PROSPERO (ID CRD42024535328). Studies reporting surgical and postoperative complications within 90 days of surgery were included as well as studies reporting on groups of complications such as urological, vascular or wound related.

Repurposing polyethylene terephthalate plastic waste to capture carbon dioxide.

Polyethylene terephthalate (PET) is a ubiquitous polymer with a lack of viable waste management solutions besides mechanical recycling, incineration, and landfilling. Herein, we demonstrate a chemical upcycling of PET waste into materials for CO capture via aminolysis. The aminolysis reaction products-a bis-aminoamide (BAETA) and oligomers-exhibit high CO capture capacity up to 3.

Charting the equine miRNA landscape: An integrated pipeline and browser for annotating, quantifying, and visualizing expression.

MicroRNAs (miRNAs) are essential regulators of gene expression, yet few comprehensive databases exist for miRNA expression in non-model species, limiting our ability to characterize their roles in gene regulation, development, and disease. Similarly, isomiRs - length and sequence isoforms of canonical miRNAs with potentially altered regulatory targets and functions - have received even less attention in non-model species, including the horse, leaving a critical gap in our understanding of their biological significance. To address these challenges, we developed an open-source, containerized pipeline for identifying and quantifying miRNAs and isomiRs (FARmiR: Framework for Analysis and Refinement of miRNAs), and an associated interactive browser (AIMEE: Animal IsomiR and MiRNA Expression Explorer).

Cell splitting in Staphylococcus aureus is controlled by an adaptor protein facilitating degradation of a peptidoglycan hydrolase.

Regulated protein degradation by Clp proteases is a highly conserved post-translational control mechanism in bacteria. In Staphylococcus aureus, the ClpXP complex targets the peptidoglycan hydrolase Sle1, maintaining a tightly regulated balance between peptidoglycan biosynthesis and hydrolysis, which is required to ensure proper cell splitting without compromising cell integrity. β-lactams antibiotics disturb this balance, leading to their bactericidal effects.

Surgical management of the colorectum in FAP: tailored approaches for optimal outcomes.

Familial adenomatous polyposis (FAP) is an inherited condition that predisposes individuals to colorectal cancer without preventive treatment. Surgical management typically involves restorative proctocolectomy with an ileal pouch anal anastomosis or colectomy with ileorectal anastomosis. Complete removal of the large intestine and rectum with a permanent stoma may also be required in selected cases.

Hands-on Distance Simulation of Technical Skills: A Systematic Review.

Distance simulation in health care has advanced rapidly, offering potential to reduce geographical barriers, costs, and carbon emissions while increasing global access to medical education. This systematic review evaluated hands-on technical skills training via distance simulation compared to traditional on-site training. Following PRISMA guidelines, 104 studies were analyzed.

The Earth Hologenome Initiative: Data Release 1.

Background: The Earth Hologenome Initiative (EHI) is a global endeavor dedicated to revisit fundamental ecological and evolutionary questions from the systemic host-microbiota perspective, through the standardized generation and analysis of joint animal genomic and associated microbial metagenomic data.

Results: The first data release of the EHI contains 968 shotgun DNA sequencing read files containing 5.2 TB of raw genomic and metagenomic data derived from 21 vertebrate species sampled across 12 countries, as well as 17,666 metagenome-assembled genomes reconstructed from these data.

Genetically determined body mass index is associated with diffuse large B-cell lymphoma in polygenic and Mendelian randomization analyses.

Obesity has been associated with non-Hodgkin lymphoma (NHL), but the evidence is inconclusive. We examined the association between genetically determined adiposity and four common NHL subtypes: diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, chronic lymphocytic leukemia, and marginal zone lymphoma, using eight genome-wide association studies of European ancestry (N = 10,629 cases, 9505 controls) and constructing polygenic scores for body mass index (BMI), waist-to-hip ratio (WHR), and waist-to-hip ratio adjusted for BMI (WHRadjBMI). Higher genetically determined BMI was associated with an increased risk of DLBCL [odds ratio (OR) per standard deviation (SD) = 1.

Surface modification of polycaprolactone with sulfated alginate for enhanced binding of a heparin-binding protein.

Surface modification of poly(ε-caprolactone) (PCL) to facilitate interactions with high pI proteins is a strategy used to enhance 3D PCL scaffolds for tissue engineering applications. The approach of the current study was to firstly optimise the surface modification on 2D films and then apply to 3D scaffolds. Melt-pressed PCL films were grafted with 2-aminoethyl methacrylate gamma radiation induced grafting to introduce amine functional groups to the substrate surfaces.

Existing Data Sources in Clinical Epidemiology: The Danish Prehospital Medical Record System.

Background: The Danish Prehospital Medical Record (DPMR) represents a pioneering nationwide electronic prehospital medical record system. While routinely collected data from the DPMR are increasingly used for research, a comprehensive description of its system and content is needed.

Objective: To provide an overview of the DPMR as a tool for research, including its structure, variables, and current volume of records.

Protective immune response in rainbow trout () against the parasitic nematode .

Introduction: Parasitic nematodes are prevalent in fish populations. The parasites are pathogenic but depress host responses, which limit clearance of the pathogens from the invasion sites. We hypothesized that one of several control strategies, which could augment protection, is immunization of the fish host with parasite antigens prior to live pathogen exposure.

Image quality assessment of photon-counting CT for patients with prostate cancer receiving radiotherapy.

Background And Purpose: Photon-counting computed tomography (PCCT) offers enhanced image quality, including improvements in contrast, spatial resolution, and noise reduction. In radiotherapy (RT), optimal image quality is critical for accurate tumor and organ-at-risk delineation. However, reconstruction parameter selection often relies on subjective assessment.

Identification of Neuritin 1 as a local metabolic regulator of brown adipose tissue.

Brown adipose tissue (BAT) plays a key role in metabolic homeostasis through its thermogenic effects and the secretion of regulatory molecules. Here we report that RAP250 haploinsufficiency stimulates BAT in mice, thus contributing to a decrease in fat accumulation. Local in vivo AAV-mediated RAP250 silencing in BAT reduces body weight and fat mass and enhances glucose oxidation, thereby indicating that RAP250 participates in the regulation of BAT metabolic activity.

Predicting total body water in infants aged 0.5-24 months and the implications for measuring breast milk intake: a secondary analysis of isotope dilution data.

Background: Total body water (TBW) is commonly used to derive estimates of body composition. The deuterium oxide dose-to-mother (DTM) technique for measuring breast milk intake requires an estimate of infant TBW. The DTM calculation employs a prediction equation for estimating infant TBW from body weight (TBW), but the general validity of this equation is unknown.