Reference Values for Minerals in Human Milk: the Mothers, Infants and Lactation Quality (MILQ) Study.

This fifth article in the series presenting reference values for nutrients in human milk describes minerals. The Mothers, Infants and Lactation Quality (MILQ) and Early-MILQ studies collected human milk samples throughout the first 8.5 mo of lactation in 1242 well-nourished women in Bangladesh, Brazil, Denmark, and The Gambia.

Does exposure to black carbon during pregnancy increase the risk of autism spectrum disorder? A cohort study from Southern Sweden.

Black carbon (BC), a major component of fine particulate matter (PM), has been implicated in adverse neurodevelopmental outcomes, including autism spectrum disorders (ASD). While PM has been associated with increased ASD risk, the specific role of BC remains uncertain. This study aimed to assess prenatal exposure to BC and risk for ASD development in a low exposure setting, using a large, high-quality register database, with disease diagnosis made by a single team.

Retention of increased maximum oxyregulation capacity in corals transplanted from an extreme mangrove environment to a reef flat.

Loss of oxygen (O) from the world's oceans to physiologically-critical levels ("hypoxia") is an important, yet understudied stressor for coral reefs. However, extreme reef-neighbouring ecosystems such as mangrove lagoons that are routinely subjected to frequent low-pO exposure (i.e.

Ancient host-associated microbes obtained from mammoth remains.

Ancient genomic studies have extensively explored human-microbial interactions, yet research on non-human animals remains limited. In this study, we analyzed ancient microbial DNA from 483 mammoth remains spanning over 1 million years, including 440 newly sequenced and unpublished samples from a 1.1-million-year-old steppe mammoth.

Accuracy of detecting critical findings using abbreviated brain MRI scan protocols as a prerequisite for AI-driven on-the-fly scan protocol adaptation.

Purpose: To evaluate the performance of an AI tool and relevant radiology professionals in detecting brain infarcts, intracranial hemorrhages, and tumors using abbreviated brain MRI scan protocols as prerequisite for an AI-driven workflow that dynamically selects additional imaging sequences based on real-time imaging findings.

Materials And Methods: A retrospective, consecutively enriched cohort of routine adult brain MRI scans from four Danish hospitals was constructed. Three consultant neuroradiologists, three radiology residents, three MR technologists, and an AI tool detected brain infarcts, hemorrhages, and tumors using an abbreviated 3-sequence protocol (DWI, SWI/T2*-GRE, T2-FLAIR) or 4-sequence protocol (DWI, SWI/T2*-GRE, T2-FLAIR, T1W) in a non-overlapping three-way split cross-over design.

Faecal egg count reduction test, deep amplicon sequencing of isotype-1 β-tubulin gene and in ovo larval development assay reveal susceptibility to benzimidazoles of porcine nematodes Oesophagostomum spp. and Ascaris suum in outdoor-reared pigs in Germany.

Oesophagostomum spp. and Ascaris suum represent the most common porcine nematodes and anthelmintic resistance (AR) to various anthelmintics has been reported for Oesophagostomum. However, the current AR status for worm populations on German farms and practical methods facilitating reliable AR detection are missing.

Exposure to per- and polyfluoroalkyl substances during fetal development and risk of testicular germ cell cancer in adulthood.

Background: Testicular germ cell cancer (TGCC) originates during fetal life. Fetal exposure to environmental chemicals may contribute to its development, but epidemiological data are lacking. We investigated per- and polyfluoroalkyl substances (PFAS), which can act as endocrine disruptors during fetal development, and TGCC risk in adulthood.

Management and treatment of chronic kidney disease in the Danish Lolland-Falster Health Study: focus on renoprotection and cardiovascular disease prevention.

Background: In the Danish population-based Lolland-Falster Health Study (LOFUS), we recently identified a chronic kidney disease (CKD) prevalence of 18%. Importantly, overall disease recognition was only 7.1%, and awareness was as low as 4.

Preoperative marking of the proximal resection margin in esophageal cancer with a surgical fiducial marker: First experiences.

Background: Neoadjuvant therapy can reduce the size of gastroesophageal tumors to the extent that they are no longer macroscopically visible. This may increase the risk of microscopic-positive resection margins. One potential method to reduce this uncertainty could be the preoperative endoscopic marking of proximal tumor margins with BioXmark, a novel liquid fiducial marker.

Chiral molecular 4f qubits by post functionalization.

We herein demonstrate the synthesis of a pair of enantiomerically pure Yb complexes by post-functionalisation of the parent Yb complex condensation with an enantiomerically pure chiral amine. The enantiomeric pair is structurally characterised by single crystal and powder X-ray diffraction, showing that it crystalises in the 222 Sohncke space group with Flack parameters close to zero, which confirms their enantiopurity. Circular Dichroism (CD) and absorption spectroscopies in the NIR reveal sharp F → F f-f transitions, with values up to 0.

Semaglutide Treatment of Antipsychotic-Treated Patients With Schizophrenia, Prediabetes, and Obesity: The HISTORI Randomized Clinical Trial.

Importance: Patients with schizophrenia have reduced life expectancy due to cardiovascular disease and obesity-related type 2 diabetes, exacerbated by second-generation antipsychotic (SGA) medication. Existing interventions have shown limited effect.

Objectives: To assess the effect of the once-weekly glucagon-like peptide-1 receptor agonist semaglutide in SGA-treated adults (aged 18-60 years) with schizophrenia, prediabetes (glycosylated hemoglobin A1c [HbA1c], 5.

Short-term effects of remote ischemic conditioning on vascular function in patients with cardiovascular diseases: a systematic review with meta-analysis.

Objective: The purpose of this systematic review with meta-analysis was to compare the short-term (≤1 month) effects of remote ischemic conditioning versus sham remote ischemic conditioning on vascular function in patients with cardiovascular diseases.

Methods: A systematic review was conducted to identify relevant studies through six healthcare science databases up to March 2025. Arterial stiffness and endothelial function were defined as the primary outcome.

Colistin resistance dynamics in under biofilm and planktonic growth.

is a major pathogen in chronic biofilm-associated lung infections, particularly in patients with cystic fibrosis. Colistin is commonly used to treat these infections, although there is little understanding of how resistance evolves when cells are grown within biofilms. The current study compared the phenotypic dynamics and genetic adaptations of colistin resistance between planktonic and biofilm-grown .

Preeclampsia, gestational hypertension, and cardiovascular disease risk: a genetic epidemiological study.

Background And Aims: Observational studies show that women with hypertensive disorders of pregnancy have greater risk of cardiovascular disease later in life. Whether these associations reflect causal pathways is uncertain. This study used genetic epidemiology to explore the causal relevance of preeclampsia and gestational hypertension on cardiovascular disease.

A Computational Study of the Vibrational and Rotational -Factors of the Diatomic Molecules LiH, LiF, CO, CS, SiO, and SiS.

The purpose of this article is to present theoretical values for the vibrational and rotational -factors of several diatomic molecules. The calculations were carried out at the multiconfigurational self-consistent field (MCSCF) level of theory. To determine the most reliable method and basis set for these calculations, the Hartree-Fock (HF) and density functional theory (DFT) approaches were also considered.

Understanding Data Analysis Steps in Mass-Spectrometry-Based Proteomics Is Key to Transparent Reporting.

Mass spectrometry (MS)-based proteomics data analysis is composed of many stages from quality control, data cleaning, and normalization to statistical and functional analysis, without forgetting multiple visualization steps. All of these need to be reported next to published results to make them fully understandable and reusable for the community. Although this seems straightforward, exhaustively reporting all aspects of an analysis workflow can be tedious and error prone.

An Overview of Developmental Disorders Leading to Dystocia in Cattle.

Dystocia due to developmental disorders causing foetal malformation is a significant challenge in bovine obstetrics, often resulting in severe birth complications. This narrative review provides an updated overview of the most common congenital syndromes associated with dystocia in cattle, emphasising both their clinical implications and underlying causes. Congenital disorders such as schistosoma reflexum, perosomus elumbis, arthrogryposis, hydrocephalus, anasarca and embryonic duplication are reviewed in detail, along with their impact on the course of calving.

Changes in circulating levels of miR-30b during minipuberty and puberty in girls.

Context: Pubertal timing is tightly controlled by the hypothalamic-pituitary-gonadal (HPG) axis. Makorin RING finger protein 3 (MKRN3) is an inhibitor of the HPG axis and microRNA-30b (miR-30b) is proposed to act as a direct regulator of hypothalamic MKRN3 expression. Similarly, microRNA-155 (miR-155) targets CEBPB, which is also suggested to be involved in the activation of the HPG axis.

Study protocol: COPD-eosinophil-guided reduction of inhaled corticosteroids (COPERNICOS) : A randomized, double-blinded, multicenter, four-arm intervention clinical trial on eosinophil-guided time-updated person-specific reduction of inhaled corticosteroid therapy and prophylactic low dose Azithromycin therapy in patients with severe or very severe chronic obstructive pulmonary disease (COPD).

Background: Inhaled corticosteroid (ICS) is frequently used for COPD. Based on the considerable adverse effects and the knowledge that many such patients do not gain benefit from this treatment, it remains unresolved whether ICS treatment can be managed with lower doses, or via an ICS-sparing strategy with periods with and without this medicine. The blood eosinophil count is a useful biomarker for steroid-responsive airway inflammation, and we want to investigate whether an individualized and eosinophil-guided approach on ICS treatment reduces ICS over-treatment and side effects.

What is the effect of homework engagement in group cognitive behavioral therapy for anxiety disorders and depression?

Background: Homework is integral to cognitive behavioral therapy (CBT) treatment programs. Previous research has reported mostly positive findings regarding the effect of homework adherence on CBT outcomes, but only limited research has evaluated the effect in transdiagnostic CBT (tCBT).

Methods: This secondary study used data from 164 patients with major depressive disorder, social phobia, agoraphobia, or panic disorder, randomized to 14 sessions of diagnosis-specific CBT (dCBT) in groups or group tCBT (Unified Protocol).

Herpesviruses, antiviral treatment, and the risk of dementia - systematic review and meta-analysis.

Introduction: The aim of this systematic review and meta-analysis was to synthesize the evidence on the association between herpesviruses, antiviral treatment, and the risk of dementia. We also aimed to explore the impact of time between herpesviruses and dementia on the reported associations.

Methods: PubMed and Web of Science were searched along with reference lists of the included studies.

Examining the thoughts and experiences of repeatedly revised knee arthroplasty patients-a qualitative study.

Background: Knee arthroplasty is a common surgical treatment aimed at improving function and reducing pain. While generally successful, some patients experience complications or dissatisfaction, leading to a sequence of revision surgeries. These revisions are less successful than primary surgeries and carry risks.

Coronary CT angiography is a safe gatekeeper in non-ST-elevation acute coronary syndrome - The VECTOR study.

Purpose: In patients with non-ST-segment elevation acute coronary syndrome (NSTEACS), coronary pathology ranges from normal vessels to severe obstructive disease. In NSTEACS patients where invasive coronary angiography (ICA) is recommended, it is unknown whether a non-invasive coronary computed tomography angiography (CCTA) may be used for patient triage. The Very Early Computerized Tomography to Organize Revascularization in patients with NSTEACS (VECTOR) study was a pilot study that assessed whether CCTA can be used to safely discharge NSTEACS patients without obstructive coronary artery disease.