Harnessing Electrocatalytic Coupling of Carbon Dioxide and Methanol for High-Efficiency Formic Acid Production.

The coupling of electrocatalytic CO reduction (ECR) and methanol oxidation reaction (MOR) presents a promising strategy for simultaneous cogeneration of formic acid (FA) at both cathode and anode. However, sluggish kinetics, low selectivity and efficiency hinder practical application. Herein, we demonstrate an integrated ECR||MOR system employing CuBi cathode and NiCo anode for energy-efficient FA cogeneration.

Chemsex: Associations with Sexual, Psychosocial and Social Health in Australian Gay and Bisexual Men.

Introduction: Chemsex, the use of psychoactive substances to enhance sexual experience, is most prominent in gay, bisexual and other men who have sex with men (GBMSM). This study explores the prevalence of chemsex in Australian GBMSM ( = 632) and its associations with psychosexual and psychosocial health.

Methods: A cross-sectional online survey was conducted.

Preparation of cold-stored platelets on-demand: A novel approach to inventory management.

Background: Cold-stored platelets (CSP) are now being used to treat acute bleeding. However, as CSP are less suitable for prophylaxis, both room temperature (RT) platelets and CSP will be required, which complicates inventory management. The production of CSP "on-demand" from RT platelets may be a desirable option.

Twenty-Eight Days Later: Emergency Diagnoses Associated With Increased Risk of Readmission, a Retrospective Observational Study of Older Adults.

Aims: To describe diagnostic categories and comorbidities associated with increased risk of readmission within 28 days among older adults.

Methods: Retrospective observational study of all hospital admissions following ED attendance by patients aged ≥ 60 years between July 2020 and June 2023. Index and subsequent 28-day readmission were identified using ED data and hospital discharge records.

Caring for carers of people with advanced cancer at hospital discharge (CARENET): A single-arm open label feasibility trial.

Objectives: Carers are critical to support discharge home from hospital at end of life yet remain under-represented in health service initiatives to assist this transition. A carer-focused intervention embedded into practice may facilitate hospital discharge. This open-labeled, single-arm phase 2 study aimed to determine the feasibility of (1) delivering a multi-staged intervention (CARENET) to carers of advanced cancer patients in a hospital setting and (2) the study design to inform a phase 3 trial.

The unexploited potential of data systems tracking medicines utilization: an opportunity to improve access to oncology combination therapies.

Background: While progress has been made in oncology treatments, including the introduction of combination therapies, barriers affect patient access. There are approaches that could improve access including combination-specific pricing that allow the price to reflect whether a product is used in monotherapy or in combination. The feasibility of this solution requires data on the utilization of combination therapies.

Denoising and reconstruction of nonlinear dynamics using truncated reservoir computing.

Measurements acquired from distributed physical systems are often sparse and noisy. Therefore, signal processing and system identification tools are required to mitigate noise effects and reconstruct unobserved dynamics from limited sensor data. However, this process is particularly challenging because the fundamental equations governing the dynamics are largely unavailable in practice.

An RGD motif on SARS-CoV-2 Spike induces TGF-β signaling and downregulates interferon.

Unlabelled: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein mediates canonical cell entry via ACE2 and has also been implicated as an activator of a diverse range of signaling pathways. Here, we present evidence that the RGD (Arg-Gly-Asp) motif within the receptor-binding domain (RBD) of the S1 fragment of the S protein induces TGF-β cytokine expression. RGD peptides are well characterized as ligands for a subset of integrin complexes primarily containing α5 and αV subunits.

Advances in applied supramolecular technologies 2021-2025.

Supramolecular chemistry is a rapidly evolving field that has focused on building a foundation of fundamental understanding in controlling molecular self-assembly, through the use of non-covalent interactions. A common criticism of the field is that whilst the systems produced are very elegant, they do not have real-world use. Therefore, focus is now moving to applying the fundamental understanding of supramolecular chemistry to the production of commercially viable products.

Complexation-based spectrofluorimetric method for besifloxacin determination: Combined experimental and computational insights.

Fluorescence-based analytical methods offer high sensitivity, cost-effectiveness, and simplicity for pharmaceutical analysis. Besifloxacin hydrochloride (Bfln.HCl), a fluoroquinolone antibiotic used to treat eye infections, exhibits native fluorescence that can be enhanced in acidic media.

How do different health states impact preferences for social care related quality of life: An exploration of EQ-5D-5L and ASCOT using a vignette approach.

Objectives: Social care related quality of life instruments, such as the Adult Social Care Outcomes Toolkit (ASCOT) are important for valuing interventions, particularly when they include utility weights. Utility weights may vary by population and health conditions, yet most value sets are developed without considering contexts. This study aims to explore this issue by assessing whether the valuation of ASCOT social states differs in the context of poor physical or mental health versus full health.

Retention of increased maximum oxyregulation capacity in corals transplanted from an extreme mangrove environment to a reef flat.

Loss of oxygen (O) from the world's oceans to physiologically-critical levels ("hypoxia") is an important, yet understudied stressor for coral reefs. However, extreme reef-neighbouring ecosystems such as mangrove lagoons that are routinely subjected to frequent low-pO exposure (i.e.

Uropathogenic Escherichia coli proliferate as a coccoid morphotype inside human host cells.

Escherichia coli is arguably one of the most studied bacterial model systems in modern biology. While E. coli are normally rod-shaped gram-negative bacteria, they are known to undergo conditional morphology changes under environmental and nutrient stress.

Women's Perceptions of Maternity Care Responses to Domestic and Family Violence and Abuse: A Systematic Review and Meta-Synthesis of Qualitative Studies.

Domestic and family violence (DFV) disproportionately affects women in the perinatal period. Routine DFV screening is known to improve DFV identification, however, it is crucial to understand women's views of routine DFV inquiry and their post-disclosure needs specific to the maternity care setting. The aim of this qualitative meta-synthesis was to explore perinatal women's perceptions and experiences of routine DFV screening and post-disclosure practices in antenatal care.

Nurse-Led Innovations for Optimising the Quality and Safety of Care for the Older Person in Residential Aged Care: A Warrant for Action.

Aim: To canvas the contemporary contextual forces within the Australian residential aged care sector and argue for new research and innovation. There is a pressing need to provide systematised, high-quality and person-centred care to our ageing populations, especially for those who rely on residential care. This paper advances a warrant for establishing a new systematic framework for assessment and management that serves as a foundation for effective person-centred care delivery.

Adapting the Grog survey app for alcohol screening and feedback in aboriginal and Torres Strait Islander health services: a mixed methods study protocol.

Background: Routine use of brief, structured screening tools is essential to detect and provide support for Australians who drink above recommended levels. However, detecting drinking above recommended levels in Aboriginal and Torres Strait Islander Australian primary care settings is complex. Inaccuracies in completing a screening tool such as Alcohol Use Disorders Identification Test - Consumption, can lead to errors in estimating drinking in First Nations contexts where group sharing and episodic drinking make it difficult to accurately estimate alcohol consumption with tools that assume regular drinking patterns.

Advances in photodynamic therapy and its combination strategies for breast cancer.

Breast cancer remains one of the leading causes of cancer-related mortality worldwide, with treatment resistance and recurrence posing significant challenges to conventional therapies such as chemotherapy, surgery, and radiotherapy. Photosensitiser-assisted treatment strategies, particularly photodynamic therapy (PDT), have emerged as a promising alternative for breast cancer due to its targeted nature and minimally invasive approach. This review provides an overview of PDT as a treatment strategy for breast cancer.

What Do We Know About Prevention of Frailty in Women?

Frailty is a multidimensional syndrome associated with a state of vulnerability to external stressors. Though women have a longer life expectancy than men, they have a higher risk of frailty. Frailty is prevalent in women, affecting ∼9-15% of community-dwelling older women, and over 50% of nursing home residents.

Lithium fine-tunes biodegradation of Zn-based implant to promote osseointegration through immunomodulation.

The intricate degradation dynamics exhibited by biodegradable alloys significantly influence host responses during the implantation process, posing challenges in achieving stable osseointegration. It is thus critical to tailor the biodegradation profiles of these implants to establish a conductive tissue microenvironment for bone tissue regeneration. In this study, we demonstrate that Zn-Li alloy forms a layer of Li-containing degradation products at the bone-implant interface to accommodate the bone regeneration process.

The Perinatal Experience of Women With a History of Intimate Partner Violence: The Birth Experience Study.

Background: Experiencing intimate partner violence impacts the ongoing physical and psychological health of women and can contribute to poorer maternal and neonatal health during the perinatal period.

Methods: In a national maternity experiences cross-sectional online survey, 1198 (13.6%) women identified as experiencing IPV in their lifetime.

Environmental factors have a greater influence on photosynthetic capacity in C plants than biochemical subtypes or growth forms.

Our understanding of how photosynthetic capacity varies among C species and across growth and measurement conditions remains limited. We collated 1696 CO response curves of net CO assimilation rate (A/C curves) from C species grown and measured at various environmental conditions and used these data to estimate the apparent maximum carboxylation activity of phosphoenolpyruvate carboxylase (V) and CO-saturated net photosynthetic rate (A), two key parameters describing photosynthetic capacity. We examined how V and A vary with species-specific traits, growth and measurement conditions.

Integrated Health-Social Hubs for Migrant Women and Infants.

Background And Objectives: Migrant families have reduced access to universal child and family health (CFH) services, including CFH nursing visits, wherein infant and maternal surveillance offers a key opportunity to identify maternal health and child developmental concerns. Evidence is emerging on the effectiveness of integrated health and social care hubs (Hubs) to improve access to CFH services. Our aim was to evaluate the impact of Hubs at 2 sites in Sydney, Australia for migrant women and their infants on attendance to CFH nursing visits until 12 months postpartum for infant and maternal surveillance.

Liposomal drug delivery system for lung diseases: Recent advancement and future perspectives.

Lung diseases such as asthma, chronic respiratory diseases, and lung cancer are among the most prevalent and vulnerable health conditions. Various therapeutic approaches, including nucleic acids, peptides, and small molecules have been developed along with different delivery strategies for their treatment. Liposomes have been recognized as promising delivery candidates attributed to their biocompatibility, biodegradability, and ability to encapsulate both hydrophilic and hydrophobic drugs effectively.

Indoor plants produce negative air ions: a comparison across species, temperature and humidity.

Negative air ions (NAI) are negatively charged gas ions, commonly released within the natural environment via plant metabolic activity. Exposure to NAI-enriched environments has been shown to provide substantial health benefits, and the ability to charge particulate matter (PM) and precipitate it from the airstream, leading it to be proposed as potential contributors to indoor botanical air purification systems. Current literature indicates low levels of NAI production by indoor plants, while there is a general consensus that reasonable levels of NAI can be produced by plants under correct physiological and microclimate conditions, the mechanisms of plant NAI generation remain insufficiently studied.