Publications by authors named "Manish Yadav"

Measurements acquired from distributed physical systems are often sparse and noisy. Therefore, signal processing and system identification tools are required to mitigate noise effects and reconstruct unobserved dynamics from limited sensor data. However, this process is particularly challenging because the fundamental equations governing the dynamics are largely unavailable in practice.

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A new series of macrocyclic complexes of lanthanum (III) derived from the template condensation reaction of bis(benzyl)-4-nitro-1,2-phenylene diamine with different diamines such as 4-nitro-1,2-phenylene diamine, 4-bromo-1,2-phenylene diamine, ethylene diamine, 1,2-diamino propane and 4-chloro-1,2-phenylene diamine in the presence of lanthanum chloride salt. The ligand was synthesized by the condensation of benzyl and 4-nitro-1,2 phenylene diamine. The synthesized complexes have been analyzed by elemental analysis, conductance measurement and characterized by spectral analysis, i.

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This paper presents the design and development of a compact multi-band high-frequency antenna tailored for millimeter-wave applications, particularly within the 6G frequency range. The antenna features a small footprint of 10 × 12 × 1.5 mm and is designed using advanced electromagnetic simulations in CST Microwave Studio.

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The relationship between a reservoir network structure and the overall performance of a reservoir computer remains an unanswered question, particularly when searching for an optimal yet small network. In this study, we introduce a systematic, task-specific node-pruning framework that enhances the efficiency while decreasing the size of the reservoir networks. We demonstrate that large networks can be compressed while preserving-or even improving-performance by node removal.

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Rice is presently cultivated over 87 % of total kharif area in Punjab. It exhibits the low water productivity with a significant portion of the applied water being prone to unproductive losses, posing a threat to the sustainability of water resources in the state. It is against the sustainable development goals 6.

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Introduction: Diabetes mellitus (DM) and thyroid dysfunction (TD) are two of the most prevalent endocrine disorders globally. Both conditions have significant effects on metabolism and are known to influence each other. Thyroid hormones play a crucial role in glucose homeostasis by affecting insulin secretion, sensitivity, and glucose metabolism.

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Cartap, a nereistoxin derivative from the marine annelid Lumbriconeresis heteropoda, is widely used as a pesticide, targeting pests like caterpillars. While the WHO classifies it as moderately hazardous, with a recommended daily intake of 0.05 mg/kg, human toxicity reports are limited.

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Complement anaphylatoxin receptors (C3aR and C5aR1) are prototypical G protein-coupled receptors (GPCRs) playing crucial physiological roles in innate immunity by combating pathogenic infections and orchestrating inflammatory responses. They continue to be important therapeutic targets for multiple disorders including autoimmune diseases, acute and chronic inflammation, and allergy-related conditions. Recent structural coverage has provided important insights into their activation and signaling, however, confounding observations in the literature related to ligand efficacy and functional responses, especially in different model systems, present a major challenge for drug discovery efforts.

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Introduction: Omental cysts are rare congenital lymphatic lesions in children, presenting as a palpable mass, abdominal distension, or acute abdomen. Complications include hemorrhage, rupture, and torsion. Diagnosis is challenging due to nonspecific symptoms, often requiring imaging.

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Selectivity of natural agonists for their cognate receptors is a hallmark of G-protein-coupled receptors (GPCRs); however, this selectivity often breaks down at the chemokine receptors. Chemokines often display promiscuous binding to chemokine receptors, but the underlying molecular determinants remain mostly elusive. Here, we perform a comprehensive transducer-coupling analysis, testing all known C-X-C chemokines on every C-X-C type chemokine receptor to generate a global fingerprint of the selectivity and promiscuity encoded within this system.

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The quest to understand structure-function relationships in networks across scientific disciplines has intensified. However, the optimal network architecture remains elusive, particularly for complex information processing. Therefore, we investigate how optimal and specific network structures form to efficiently solve distinct tasks using a framework of performance-dependent network evolution, leveraging reservoir computing principles.

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Introduction: Enterally-based resuscitation (EResus) is safe, efficacious, and has operational advantages, particularly in low-resource settings. However, there is a lack of real-world effectiveness studies and evidence-based protocols, which hinders implementation. To address this gap, we conducted a feasibility study ahead of a randomized controlled trial (RCT) of enterally based versus usual resuscitation at a tertiary burn center in Nepal which had no prior clinical trial experience.

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Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS) is a rare congenital disorder characterized by agenesis of the uterus and upper two-thirds of the vagina. It affects around 1 in 4000-5000 females and is of two types: type 1, also known as isolated Müllerian aplasia or Rokitansky, which involves only uterovaginal agenesis, and type 2, presents as uterovaginal agenesis along with renal, cardiac, and other organ anomalies. Despite the absence of vaginal and uterine structures, individuals with MRKHS typically present with normal secondary sexual characteristics and ovarian functions.

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This study explores the fabrication of nickel-oxide-embedded laser-induced graphene and its application in high-performance supercapacitors. Supercapacitors are critical for various applications due to their high power density and long cycle life. Nevertheless, they suffer from lower energy density compared to batteries.

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Hypoglycemic encephalopathy is a rare yet life-threatening diabetes complication, where overlapping symptoms with neurological conditions can delay diagnosis. Early recognition and treatment are crucial to prevent irreversible brain damage. Clinicians should suspect hypoglycemia in diabetic patients with altered mental status, as timely intervention improves outcomes and reduces mortality.

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Introduction The purpose of this study is to assess the effectiveness and short-term outcomes of prostatic artery embolization (PAE) in Indian patients suffering from benign prostatic hyperplasia (BPH). Methods This retrospective analysis was performed at a single center and included 25 patients with BPH who received PAE from January 2019 to June 2023. The symptoms of patients had been assessed utilizing the International Prostate Symptom Score (IPSS) and the Quality of Life (QoL) questionnaire.

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Article Synopsis
  • Burn injuries are a significant global health issue, particularly in low- and middle-income countries like Nepal, where access to standard IV fluid resuscitation is often poor, prompting the need to explore alternative methods such as enteral resuscitation using oral rehydration solution (ORS).
  • A study conducted through focus group discussions with 45 burn care providers revealed that stakeholder involvement in developing the enteral resuscitation protocol fostered acceptance and enthusiasm for its implementation, driven by a collective desire to enhance patient outcomes.
  • Despite the benefits observed, challenges such as difficulties in administering the correct volume, technical errors, and limited resources underscored the need for ongoing training and systemic support to ensure the effective use of enteral resuscitation
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Paraquat poisoning poses a significant and emerging public health challenge in developing countries. The distribution and usage of Paraquat, a potent herbicide, remain unrestricted in many regions despite its high fatality rate and absence of a specific antidote. Paraquat mostly involves lungs but can also involve the kidneys and liver.

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  • Dent disease type 1 is linked to issues with the CLCN5 gene on the X chromosome, leading to problems like protein in urine and high calcium levels.
  • Previous attempts at gene therapy showed short-term success in mice, likely hampered by immune responses against the ClC-5 protein.
  • New strategies focused on targeting kidney cells and treating newborn mice show promise, suggesting that early intervention could improve outcomes and reduce immune rejection in patients with Dent disease type 1.
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Article Synopsis
  • Brain abscesses (BAs) are serious pyogenic infections in the brain that can be fatal if untreated; they are rare in neonates, especially those caused by fungi.
  • A 20-day-old newborn with fever, jaundice, and seizures was diagnosed with multiple cerebral abscesses caused by a fungus, leading to surgical drainage and antifungal treatment.
  • Managing fungal BAs in neonates is challenging due to their similarity to bacterial infections, but early detection and treatment can significantly improve survival rates.
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Introduction: Rheumatic heart disease (RHD) poses a substantial global health challenge, especially impacting resource-limited nations, with over 40.5 million cases reported in 2019. The crucial role of Benzathine penicillin G in both primary and secondary prevention, particularly the latter, emphasizes its significance.

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Introduction: The coexistence of insomnia and obstructive sleep apnea (OSA) poses a complex and challenging clinical scenario, commonly referred to as comorbid insomnia and OSA (COMISA). The bidirectional relationship between these two sleep disorders is explored, illuminating how the presence of one can exacerbate the severity and manifestations of the other. We under took this study to understand the prevalence of COMISA in Indians which is never studied.

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Background: Drug resistant (DR) osteoarticular TB (OATB) is a challenge in view of it being deep seated lesion and paucibacillary disease. Case definition, investigation protocol, treatment of proven DR and those cases where DR could not be demonstrated lacks clarity and evidence. Hence, a series of studies were conducted to develop an algorithm to investigate and treat therapeutically refractory disease (TRD) or presumptive drug resistance (PDR) cases of OATB.

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Introduction: Hydatidosis, caused by Echinococcus granulosus, is endemic in regions where cattle rearing is prevalent. While liver and lung involvement are common, isolated splenic hydatid cysts are rare, particularly among adolescents. We present a rare case of a 14-year-old female with an isolated giant splenic hydatid cyst.

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