Large cell neuroendocrine tumor of lung with hemorrhagic cerebral metastasis: A case report.

Large cell neuroendocrine carcinoma (LCNEC) of the lung is a rare, high-grade malignancy within the spectrum of pulmonary neuroendocrine tumors, characterized by aggressive behavior and poor prognosis. LCNEC commonly metastasizes to the liver, bone, and adrenal glands, with brain metastasis occurring in 10-20% of cases. Hemorrhagic cerebral metastasis, however, is infrequent and its pathophysiology remains poorly understood.

McIndoe Vaginoplasty in MRKHS: Case Report and Literature Review.

Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS) is a rare congenital disorder characterized by agenesis of the uterus and upper two-thirds of the vagina. It affects around 1 in 4000-5000 females and is of two types: type 1, also known as isolated Müllerian aplasia or Rokitansky, which involves only uterovaginal agenesis, and type 2, presents as uterovaginal agenesis along with renal, cardiac, and other organ anomalies. Despite the absence of vaginal and uterine structures, individuals with MRKHS typically present with normal secondary sexual characteristics and ovarian functions.

Right-sided Poland syndrome with no classical hand deformity: A case report.

Poland syndrome (PS) is a rare congenital condition characterized by the developmental anomaly of the chest wall, and classically presents with ipsilateral agenesis/hypoplasia of sternocostal head of pectoralis major which remains as the essential feature of the condition. It may or may not be associated with ipsilateral limb abnormalities. Diagnosis is mainly clinical.

Remote rupture of ovarian dermoid cyst: A curious case report.

Ovarian dermoid cysts are usually asymptomatic and detected incidentally. However, they can have variable presentation especially when they are associated with complications. Spontaneous rupture of ovarian dermoid cyst is a rarely encountered complication as dermoid cyst usually have a thick capsule.

Prenatal diagnosis of the rarest conjoint twin "diprosopus tetrophthalmus" during anomaly scan: A case report.

Twin pregnancy is considered high-risk pregnancy because of its various effects on maternal and fetal physiology. Twin pregnancy can be dizygotic or monozygotic, the latter being less common. Depending upon the period of separation of an embryo, monozygotic twins can share amniotic cavity and placenta with the monochorionic monoamniotic form being the least common type.

Metastatic choriocarcinoma presenting as upper gastrointestinal bleeding: A case report.

Choriocarcinoma is a type of gestational trophoblastic disease that occurs as a complication of pregnancy-related events. The gestational trophoblastic disease includes both benign and malignant conditions including complete and partial mole, invasive mole, choriocarcinoma, and placental site trophoblastic disease. Choriocarcinoma generally presents with pervaginal bleeding, symptoms of anemia, and symptoms of its metastatic lesion.

Getting the diagnostic clue, role of MRI in the diagnosis of type 1 Glutaric aciduria in resource-limited settings.

Glutaric aciduria type 1 is a rare autosomal recessive disorder caused by a deficiency of glutaryl-CoA dehydrogenase, which is the key mitochondrial enzyme involved in the final degradation of lysine, L-hydroxylysine, and L-tryptophan. It is an inherited organic acidemia characterized by macrocephaly and dystonia, which results in high morbidity and mortality. In resource-limited countries like Nepal, where enzyme assays are not available, MRI has a great role to play in supporting diagnosis in such situations.

Diagnostic dilemma in female genital tract tuberculosis: A case report.

Female genital tract tuberculosis presents a diagnostic challenge because of its variable clinical presentation and radiological manifestation. Most patients are present with history of infertility, pain in the abdomen, vaginal discharge, and bleeding. These symptoms mimic those of gynecological cancer, such as endometrial carcinoma.

The double target sign as ultrasonographic finding in a case of double intussusception: A case report.

Intussusception is one of the common conditions in children presenting with abdominal pain. The exact etiology of intussusception is unknown. Lead point is not identified in the majority of cases in children.

Late Presentation of Hypoxic Injury of Brain in an Infant.

Perinatal asphyxia is one of the leading causes of hypoxic-ischemic encephalopathy. In a developing country like Nepal, home delivery is the leading cause of perinatal asphyxia. Neuroimaging remains the diagnostic modality of choice.