Cyclic Heptapeptide FZ1 Acts as an Integrin αvβ3 Agonist to Facilitate Diabetic Skin Wound Healing by Enhancing Angiogenesis.

Diabetic wound healing remains a persistent clinical challenge, necessitating the development of effective therapeutic agents and a deeper understanding of regulatory mechanisms. The cyclic heptapeptide FZ1, characterized by favorable biocompatibility, exhibited significantly greater efficacy than rh-bFGF and Cy in promoting cell proliferation and migration. In diabetic wound models, FZ1 markedly accelerated tissue regeneration and stimulated angiogenesis, as indicated by the upregulation of CD31 and α-SMA.

Green-Synthesized Silver Nanoparticle-Loaded Antimicrobial Films: Preparation, Characterization, and Food Preservation.

This study presented a novel antimicrobial packaging PVA/xanthan gum film decorated with green-synthesized silver nanoparticles (AgNPs) derived from () for the first time. Montmorillonite (MMT) was used to improve its dispersion (AgNPs@MMT). The synthesis time, temperature, and concentration of AgNO were considered using a central composite design coupled with response surface methodology to obtain the optimum AgNPs (2 h, 75 °C, 2 mM).

Fabrication of a high-sensitivity electrochemical immunosensor by the oriented immobilization of engineered nanobody on nanofibrous membrane.

A new type of label-free electrochemical immunosensor for the high-sensitivity determination of parathion was developed based on the oriented immobilization of nanobody (VHH9) on a gold nanoparticle-loaded polyvinyl alcohol/citric acid nanofiber membrane-modified electrode. The morphology characterization and assembly process of the modified materials were investigated using scanning electron microscopy (SEM) and electrochemical impedance spectroscopy (EIS). Under the optimum conditions, the label-free electrochemical immunosensor for parathion exhibited a linear range of 0.

A highly sensitive electrochemical immunosensor based on electrospun nanocomposite for the detection of parathion.

For monitoring of the residual of parathion pesticide in food, herein, a sensitive and reliable electrochemical immunosensor based on cross-linked polyvinyl alcohol/citric acid nanofiber membrane (PVA/CA NFM) and horseradish peroxidase labeled anti-parathion nanobody was constructed. Firstly, the cross-linked PVA/CA NFM with extra-high surface area and uniform morphology was prepared and characterized. Then, the immunosensor was assembled and its analytical performances were evaluated.

[Dynamic change of phenolic acids in soils around rhizosphere of replanted Rehmannia glutinosa].

Objective: To determine 5 phenolic acids in the soils around rhizosphere of Rehmannia glutinosa in the field under normal rotation and successive cropping.

Method: Phenolic acids related to allelopathy effect in the soils around rhizosphere of R. glutinosa were determined by HPLC.

[Effects of continuous cropping obstacle on growth of Rehmannia glutinosa].

Objective: To study the effects of continuous cropping obstacles on growth of Rehmannia glutinosa.

Method: The growth indexes, activity of root ATPase, root activity and mineral nutritional absorption were determined.

Result: Continuous copping decreased growth rate and declined the size of leaves.