Coffee-Ring Suppression in Inkjet-Printed Perovskite Films Enabled by a Shape-Anisotropic Nanorod Solute Strategy.

Achieving uniform perovskite thin films via inkjet printing remains a significant challenge due to the pervasive coffee-ring effect. Here, we present a solute engineering strategy that incorporates shape-anisotropic perovskite nanorods into a single-solvent ink formulation, effectively suppressing coffee-ring formation and yielding ultraflat films with an average roughness (Ra) as low as 0.226 nm.

Degradation of IRAK4 for the treatment of lipopolysaccharide-induced acute lung injury in mice.

Excessive pulmonary inflammation in acute lung injury (ALI) results in high patient mortality. Interleukin-1 receptor-associated kinase 4 (IRAK4) is a potential therapeutic target for inflammatory diseases. However, due to the dual functionality of IRAK4 as both an active kinase and a scaffolding protein, inhibiting its kinase activity yield moderate anti-inflammatory results.

Surgical treatment outcomes of naso-orbito-ethmoid fractures using 3D printing-assisted patient specific mesh: a prospective study.

Background: This study aimed to investigate the efficacy of three-dimensional (3D) printing-assisted treatment for naso-orbito-ethmoid (NOE) fractures and to compare it with conventional surgical methods.

Methods: This research conducted a retrospective analysis of 84 patients with NOE fractures who received surgical treatment at the 900th Hospital of Joint Logistics Support Force of the Chinese People's Liberation Army from January 2018 to July 2023. The patients were divided into two groups based on whether 3D printing was applied as the experimental group ( = 44) and the traditional group ( = 40).

LC-MF-4, a Novel FGFR3 Degrader for Therapeutic Intervention in FGFR3-Altered Cancers.

Alterations in the fibroblast growth factor receptor 3 (FGFR3) gene have been noted in human diseases, including bladder cancer and urothelial carcinoma (UC). Erdafitinib was approved for the treatment of UC but is limited by the progression of on-target gatekeeper resistance mutations. Several heterobifunctional FGFR degraders have been developed as potential therapeutic agents to block FGFR1 or FGFR2 signaling.

Differential Effects of Prenatal Poly I:C Exposure and Antipsychotics on NMDA/GABA Receptors and GSK3β-Mediated Signaling in the Dorsal Raphe Nucleus of Female Rats.

Background: The dorsal raphe nucleus (DRN) is the origin of the 5-HT neurotransmission pathways. The 5-HT, dopamine D2, GABA, and NMDA receptors, as well as the cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) and G protein-independent protein kinase B (PKB/Akt)-glycogen synthase kinase 3β (GSK3β) signaling, are involved in the pathophysiology of schizophrenia and are modulated by antipsychotics. However, their pathological changes and antipsychotic modulations in the DRN are not well understood in schizophrenia.

Integrated multi-omics analysis reveals the functional signature of microbes and metabolomics in pre-diabetes individuals.

Pre-diabetes (PD) represents a critical stage in the progression toward type 2 diabetes, with significant alterations observed in the human microbial community among pre-diabetic individuals in observational studies. However, understanding the interaction between human microbiota and the host during pre-diabetes remains limited. Therefore, this study aims to understand the alterations in the human microbial community during pre-diabetes, a critical stage toward type 2 diabetes.

Metalla-Aromatic Oligomers: Efficient Photocatalytic Activation for Phototherapy.

Monodisperse oligomers, positioned as intermediates between polymers and small molecules, retain certain reactivities of small molecules while simultaneously displaying the initial aggregation characteristics of the polymers. This distinctive structure bestows on them with significant potential for a wide range of applications. In this study, a series of carbolong osmium oligomers (-) and corresponding polymer were evaluated as photocatalysts.

Electrical percolation network based on nano-cellulose template for flexible hydrogel bioelectrode.

Hydrogel based electrodes have been applied in the field of bioelectronics, which is of great significance for constructing a robust human-computer interface. However, achieving both reliable conductivity and tissue matching mechanical properties remains challenging. Here, we report a synergistic strategy for constructing a hydrogel electrode for bioelectronic interface with tissue modulus and high conductivity by bacterial cellulose (BC) template induced growth polypyrrole (PPy) electrical percolation network combining a polymethacryloyloxyethyl trimethyl ammonium chloride (PDMC) hydrophilic network.

Discovery of LC-SF-14, a selective dual inhibitor of SHP2 and FGFR for the treatment of FGFR2-driven gastric cancer.

Src homology-2 domain-containing phosphatase 2 (SHP2) and fibroblast growth factor receptor 2 (FGFR2) are oncoproteins. Despite the tremendous progress achieved with SHP2 allosteric inhibitors, the efficacy of single-agent SHP2 inhibitor treatments has been shown to be suboptimal, based on recent clinical trial results. A previous study demonstrated the synergistic effect of the allosteric SHP2 inhibitor SHP099 and the FGFR inhibitor BGJ398, suggesting a potential combined targeted therapeutic option for cancer.

A cross-sectional study on the relationship between dietary magnesium intake and periodontitis in different body mass index and waist circumference groups: National Health and Nutrition Examination Survey, 2009-2014.

This cross-sectional study aimed to investigate the correlation between magnesium consumption and periodontitis in different body mass index (BMI) and waist circumference (WC) groups. 8385 adults who participated in the National Health and Nutrition Examination Survey during 2009-2014 were included. The correlation between dietary magnesium intake and periodontitis was first tested for statistical significance by descriptive statistics and weighted binary logistic regression.

One-step microbial cultivated bacterial cellulose membrane with 1D/2D nanochannels for efficient osmotic energy conversion.

Osmotic energy conversion based on bio-inspired layered membranes has garnered significant interest. However, traditional biomass ion-selective membranes suffer from complex preparation, uneconomic nature, poor selectivity, and low power density. Here, we introduce scalable one-step in situ culture for nanofluidic membrane materials (GO/C-BC) composed of graphene oxide (GO), carboxymethyl cellulose sodium salt (CMC), and bacterial cellulose (BC).

Ahmed glaucoma valve implant for refractory glaucoma in children: A systematic review and meta-analysis.

Purpose: The aim of this study was to evaluate the efficacy and safety of the Ahmed glaucoma valve in pediatric patients with refractory glaucoma.

Methods: A comprehensive literature search was conducted across multiple major databases, including PubMed, Embase, the Cochrane Library of Systematic Reviews, Science Direct, China's National Knowledge Infrastructure, and the Wanfang database. We retrieved studies published before December 2022 that met the inclusion criteria, including clinical controlled trials (randomized controlled trials) and clinical noncontrolled trials (non-randomized controlled trials) on the use of Ahmed glaucoma valve in pediatric patients with refractory glaucoma.

FFA intervention on LO2 cells mediates SNX-10 synthesis and regulates MMP9 secretion in LX2 cells via TGF-β1.

Background: Metabolic-associated fatty liver disease (MAFLD) is a public health concern. Transforming growth factor-β1(TGF-β1) plays an important regulatory role in multiple MAFLD stages, as it can promote the expression of matrix metalloproteinase-9 (MMP9) and promote liver fibrosis. Sorting nexin protein-10 (SNX-10) may be involved in the occurrence and development of fatty liver disease.

Bridged Carbolong Modulating Interfacial Charge Transfer Enhancement for High-Performance Inverted Perovskite Solar Cells.

Efficient regulation of perovskite/C interface is crucial to improving the long-term stability of the inverted perovskite solar cells (PSCs). However, precise methods for controlling the perovskite/C interface have yet to be thoroughly explored. Herein, we develop a carbolong chemical manipulation strategy to improve the interface contact of perovskite/C due to versatile functional groups and excellent optoelectronic properties of carbolong metallaaromatics.

Wearable Device with High Thermoelectric Performance and Long-Lasting Usability Based on Gel-Thermocells for Body Heat Harvesting.

Utilizing the thermogalvanic effect, flexible thermoelectric materials present a compelling avenue for converting heat into electricity, especially in the context of wearable electronics. However, prolonged usage is hampered by the limitation imposed on the thermoelectric device's operational time due to the evaporation of moisture. Deep eutectic solvents (DESs) offer a promising solution for low-moisture gel fabrication.

Olanzapine Modulate Lipid Metabolism and Adipose Tissue Accumulation via Hepatic Muscarinic M3 Receptor-Mediated Alk-Related Signaling.

Olanzapine is an atypical antipsychotic drug and a potent muscarinic M3 receptor (M3R) antagonist. Olanzapine has been reported to cause metabolic disorders, including dyslipidemia. Anaplastic lymphoma kinase (), a tyrosine kinase receptor well known in the pathogenesis of cancer, has been recently identified as a key gene in the regulation of thinness via the regulation of adipose tissue lipolysis.

Biocontrol potential of plant growth-promoting rhizobacteria against plant disease and insect pest.

Biological control is a promising approach to enhance pathogen and pest control to ensure high productivity in cash crop production. Therefore, PGPR biofertilizers are very suitable for application in the cultivation of tea plants (Camellia sinensis) and tobacco, but it is rarely reported so far. In this study, production of a consortium of three strains of PGPR were applied to tobacco and tea plants.

Depletion of SLC7A11 Sensitizes Nasopharyngeal Carcinoma Cells to Ionizing Radiation.

Background: Radiotherapy is the primary treatment choice for Nasopharyngeal Carcinoma (NPC). However, its efficacy is compromised due to radioresistance. Ferroptosis, a novel iron-dependent regulated cell death induced by Ionizing Radiation (IR), plays a role in promoting cancer cell death.

Covalently grafting polycation to bacterial cellulose for antibacterial and anti-cell adhesive wound dressings.

Hydrogel-based wound dressings are becoming increasingly important for wound healing. Bacterial cellulose (BC) has been commonly used as wound dressings due to its good in vitro and in vivo biocompatibility. However, pure BC does not possess antibacterial properties.

Discovery of LC-MI-3: A Potent and Orally Bioavailable Degrader of Interleukin-1 Receptor-Associated Kinase 4 for the Treatment of Inflammatory Diseases.

Interleukin-1 receptor-associated kinase 4 (IRAK4) is a promising therapeutic target in inflammation-related diseases. However, the inhibition of IRAK4 kinase activity may lead to moderate anti-inflammatory efficacy owing to the dual role of IRAK4 as an active kinase and a scaffolding protein. Herein, we report the design, synthesis, and biological evaluation of an efficient and selective IRAK4 proteolysis-targeting chimeric molecule that eliminates IRAK4 scaffolding functions.

A 700Â nm LED Light Activated Ru(II) Complex Destroys Tumor Cytoskeleton via Photosensitization and Photocatalysis.

Photoactivable chemotherapy (PACT) using metallic complexes provides spatiotemporal selectivity over drug activation for targeted anticancer therapy. However, the poor absorption in near-infrared (NIR) light region of most metallic complexes renders tissue penetration challenging. Herein, an NIR light triggered dinuclear photoactivable Ru(II) complex (Ru2) is presented and the antitumor mechanism is comprehensively investigated.

Bacterial cellulose-based hydrogel with regulated rehydration and enhanced antibacterial activity for wound healing.

Bacterial cellulose (BC) hydrogels are promising medical biomaterials that have been widely used for tissue repair, wound healing and cartilage engineering. However, the high water content of BC hydrogels increases the difficulty of storage and transportation. Moreover, they will lose their original hydrogel structure after dehydration, which severely limits their practical applications.

Automatic quantitative stroke severity assessment based on Chinese clinical named entity recognition with domain-adaptive pre-trained large language model.

Background: Stroke is a prevalent disease with a significant global impact. Effective assessment of stroke severity is vital for an accurate diagnosis, appropriate treatment, and optimal clinical outcomes. The National Institutes of Health Stroke Scale (NIHSS) is a widely used scale for quantitatively assessing stroke severity.