Factors influencing the health behaviors of patients with ischemic stroke from a social-ecological perspective: a cross-sectional study.

Background: Although numerous studies have investigated factors associated with health behaviors in patients with first-onset ischemic stroke, the variables examined have varied substantially. Moreover, most analyses have employed ordinary linear regression models that treat variables across different levels as equivalent, thereby overlooking the nested structure of influencing factors. To address this methodological limitation, the present study adopts the Social-Ecological Model as a theoretical framework and employs hierarchical linear modeling (HLM) as a statistical approach.

Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine.

Ethnopharmacological Relevance: In Traditional Chinese Medicine (TCM), dampness is a pathogenic factor arising from impaired production and transportation of bodily fluids. While Fuling Zexie decoction (FLZXD) has demonstrated therapeutic efficacy in dampness constitution (DC) treatment, the material basis underlying its constitutional modulatory effects remains unclear.

Aim Of The Study: This study proposes objective indicators for the differentiation and therapeutic evaluation of DC and elucidates the material basis of FLZXD in DC treatment.

Interplay between tumor mutation burden and the tumor microenvironment predicts the prognosis of pan-cancer anti-PD-1/PD-L1 therapy.

Introduction: Immune checkpoint inhibitors (ICIs) have revolutionized the treatment landscape for advanced cancers, yet their efficacy remains heterogeneous among patients. Tumor mutation burden (TMB) has been extensively explored as a potential biomarker for predicting ICI response. However, its application is limited by several factors, including inconsistent predictive power across different tumor types and the lack of a clear relationship with overall survival (OS).

Specific Inulin in Exerts Immunological Enhancement by Promoting Cellular Uptake and Regulating p65-Dependent MAPK and NF-κb Pathways.

An inulin-type fructan (CPS0.2B) from an edible traditional Chinese medicine (TCM) named was found to exhibit immunological enhancement both and . However, the commercial inulin, which has an almost identical molecular weight and monosaccharide composition as CPS0.

Oligomeric hyaluronic acid-modified liposomes effectively improved skin permeability and anti-ageing activity of ellagic acid.

To overcome natural skin barrier, deliver ellagic acid (EA) to the dermis, and promote its anti-ageing efficacy, oligomeric hyaluronic acid (HA) modified EA-loaded liposomes (EA-HA-L) were constructed via self-synthesized different molecular weights of HA linked cholesterol (HA-Chol), and then the effect of HA molecular weight on the skin permeability of EA was explored to clarify the optimal molecular weight of HA with best transdermal delivery effectiveness. Finally, a series of in vitro and in vivo experiments were conducted to survey the transdermal mechanism, skin irritation, antioxidant, anti-photo ageing and antiwrinkle effects of EA-loaded liposomes modified with the optimal molecular weight of HA. The results showed that EA-HA-L had less than 200 nm particle size and high encapsulation efficiency.

Exercise-diet intervention ameliorates but fails to fully reverse obesity-induced ovarian dysfunction: evidence spanning folliculogenesis to embryonic development.

Obesity, a globally prevalent chronic disease, disrupts systemic homeostasis and impairs female fertility, yet the mechanisms linking adipose dysfunction to ovarian reserve remain unclear. Using high-fat diet-induced obese C57BL/6 mouse models (HFD) and exercise-diet intervention models (SE group), we systematically evaluated obesity-associated reproductive deficits. Histomorphological analysis revealed that HFD mice exhibited ovarian atrophy, increased atretic follicles, and reduced primordial/antral follicle counts, which were partially restored by SE intervention.

Opposing roles of pseudokinases NRBP1 and NRBP2 in regulating L1 retrotransposition.

Gene duplication generates gene paralogs that may undergo diverse fates during evolution, and thus serves as a potent catalyst of biological complexity. Genetic paralogs frequently share redundant functions and may also exhibit antagonistic activities by competing for common interaction partners. Here we show that the gene paralogs NRBP1 and NRBP2 oppositely regulate long interspersed nuclear element-1 (L1) retrotransposition, via influencing integrity of the L1 ribonucleoprotein complex.

Efficacy and Safety of Hormone Replacement Combined With Escitalopram in the Treatment of Chronic Insomnia in Perimenopausal Women: A Randomized Controlled Trial.

Aims: To explore the efficacy of Femoston plus escitalopram for perimenopausal women with chronic insomnia and the relevant biomarkers.

Methods: A total of 166 patients randomly received: escitalopram plus placebo (Escitalopram Group), Femoston plus placebo (Hormone Group), and Femoston plus escitalopram (Combined Group) for 3 months and followed for 2, 4, 8, and 12 weeks. The primary efficacy endpoint was changes in Pittsburgh Sleep Quality Index Scale (PSQI), Insomnia Severity Index Scale (ISI), and Epworth Sleepiness Scale (ESS) scores at week 12 from baseline.

Integrated multi-omics analysis reveals the functional signature of microbes and metabolomics in pre-diabetes individuals.

Pre-diabetes (PD) represents a critical stage in the progression toward type 2 diabetes, with significant alterations observed in the human microbial community among pre-diabetic individuals in observational studies. However, understanding the interaction between human microbiota and the host during pre-diabetes remains limited. Therefore, this study aims to understand the alterations in the human microbial community during pre-diabetes, a critical stage toward type 2 diabetes.

Polymeric photonic crystal platform for organic amines detection based on enzyme inhibition.

Background: The extensive use of organic amines in industries has led to significant environmental concerns. Traditional detection methods, such as chromatography, are highly accurate but costly, time-consuming, and require specialized equipment, limiting their practical use in routine environmental monitoring. This underscores the need for portable, cost-effective, and user-friendly detection technologies.

Yinling Qushi Granule as a therapeutic agent for metabolic syndrome: pharmacological, molecular targets, and pharmacokinetic insights.

Metabolic Syndrome (MetS) is a globally prevalent condition with unclear underlying mechanisms. Current treatments primarily focus on alleviating individual symptoms, lacking long-term therapeutic strategies that target the disease's endotypes. In this study, we found that Yinling Qushi Granule (YLQSG), a formulated prescription for treating Dampness Syndrome (DS) in Traditional Chinese Medicine (TCM), effectively attenuated hypertension associated with MetS.

Simulation of three dimensional diffraction patterns as aid of structural analysis for complex epitaxial films.

Thin film is the form of material that most closely resembles the silicon-based integrated circuits (IC) and therefore has attracted tremendous attention over the past decades due to its potential applications in integrating functional devices on IC chips. The structural characterization of thin films, especially epitaxial film with complex structure has been a long-term challenge until the emergence of synchrotron three-dimensional diffraction technique (3D-RSM). 3D-RSM is a technique that can effectively collect various structural information of epitaxial films, such as crystal lattice, strain, domain variants, and oxygen octahedral rotation.

Joint association of frailty index and biological age with chronic obstructive pulmonary disease: a cohort study from CHARLS.

Chronic Obstructive Pulmonary Disease (COPD) is associated with frailty and ageing, but there is insufficient evidence from existing longitudinal studies. This research explored the longitudinal association between frailty, ageing and COPD. We used the China Health and Retirement Longitudinal Study (CHARLS) data to perform a cohort study.

Tracking Early Cavitation in iPP: Insights from SEM During Uniaxial Stretching.

Semicrystalline polymers exhibit complex structural evolution during uniaxial stretching, including the formation of cavities, which significantly affect their material properties. However, in-depth studies are still lacking in understanding the early stage of cavitation due to limitations in existing techniques. This study presents a detailed investigation of the early-stage cavitation of isotactic polypropylene (iPP) during uniaxial stretching using SEM-based in situ observations, which provides real-time, high-resolution visualization of the morphological changes.

Efficacy and Safety of Escitalopram Combined with Tandospirone Citrate in Treating Patients with Vascular Depression and Chronic Insomnia: A Randomized Controlled Trial.

Background And Objective: Chronic sleeplessness is a primary clinical symptom of vascular depression (VaDep). We investigated the efficacy and safety of escitalopram plus tandospirone citrate for patients with VaDep and chronic insomnia and the potential correlation of insomnia severity with neurotransmitter indexes, including serotonin (5-HT), serotonin 2C receptor (5-HTR), serotonin 7 receptor (5-HTR) in platelets, and plasma 5-HT.

Methods: This double-blind, randomized controlled study randomized patients with VaDep and chronic insomnia [Hamilton depression rating scale (HAMD) > 17 points] into a monotherapy group [escitalopram (10 mg once daily) plus placebo] or combined group [escitalopram (10 mg once daily) plus tandospirone citrate (10 mg three times daily)] by using a 1:1 assignment algorithm generated by SPSS 25.

Peiyuan Ningshen-ointment alleviates learning and memory impairment induced by sleep deprivation through activating the cAMP/PKA signaling pathway.

Background: Sleep Deprivation (SD) seriously impacts the brain's learning and memory functioning, and the treatment methods and their efficacy are limited. PYNS ointment (Peiyuan Ningshen-ointment) is an herbal ointment consisting of eleven Chinese herbs, which have been proven to have positive therapeutic effects on learning and memory impairment. However, its mechanism of action is still unclear.

TOM20-driven E3 ligase recruitment regulates mitochondrial dynamics through PLD6.

Mitochondrial homeostasis is maintained through complex regulatory mechanisms, including the balance of mitochondrial dynamics involving fusion and fission processes. A central player in this regulation is the ubiquitin-proteasome system (UPS), which controls the degradation of pivotal mitochondrial proteins. In this study, we identified cullin-RING E3 ligase 2 (CRL2) and its substrate receptor, FEM1B, as critical regulators of mitochondrial dynamics.

Green fabrication of antimicrobial film for food preservation by polysaccharides from Poria Cocos.

Recently, polysaccharide-based film materials have attracting widespread attentions due to their safety, biodegradability, and film-forming properties. However, the limited UV resistance, antibacterial and mechanical properties of polysaccharides severely restrict their applications in food packaging. This work developed a biocomposite film (PGF@Ag) consited of a natural β-glucan from Poria Cocos (PCPA), in-situ synthesized AgNPs and glycerol, showing good antibacterial and antioxidant properties as well as biocompatibility and mechanical properties.

Effects of Chenpi Jiaosu on serum metabolites and intestinal microflora in a dyslipidemia population: a randomized controlled pilot trial.

Introduction: Dyslipidemia is a critical risk factor for atherosclerosis and cardiovascular/cerebrovascular events, necessitating effective long-term management. However, conventional lipid-lowering drugs such as statins and fibrates are limited by adverse effects, including hepatotoxicity and myopathy, which restrict their prolonged use. Traditional Chinese medicine (TCM) and natural health products offer potential alternatives with multi-target mechanisms and improved safety profiles.

Migrasome-related ITGA5 for predicting prognosis, immune infiltration and drug sensitivity of hepatocellular carcinoma.

To clarify the biological functions and prognostic significance of migrasome-related integrin subunit alpha 5 (ITGA5) in hepatocellular carcinoma (HCC). We used The Cancer Genome Atlas datasets and RNA-seq data from nine sets of paired HCC and adjacent normal tissues to identify key migrasome-related genes through a comprehensive analysis and weighted correlation network analysis. We then confirmed their roles in HCC through analyses of gene mutations, methylation, and immune cell infiltration, as well as molecular docking, molecular dynamics, and cell experiments.

Construction of dual-targeted liposomes loaded with celastrol and their application in treating intrahepatic cholangiocarcinoma.

Intrahepatic cholangiocarcinoma (ICC) is a rare malignant tumor with limited treatment options. Celastrol (Cela) shows potential treatment for ICC, but its clinical use is hindered by poor water solubility and toxic side effects. To address these challenges and enhance its anti-tumor efficacy, we developed hyaluronic acid (HA)-coated triphenylphosphine complex-modified liposomes (HCTL) for accurate delivery of Cela to tumor cell mitochondria.

Alkaline-thermal synergistic activation of persulfate for sawdust hour-level humification to prepare fulvic-like-acid fertilizer.

Sawdust is a by-product of wood processing and it was rapidly humified with KSO under alkaline-thermal synergistic activation to produce a fulvic-like-acid (FLA) organic fertilizer (SFOF) in this study. The optimum conditions were KSO: KOH mass ratio of 1:2 and 150°C, meanwhile FLA yield could reach 180.3 mg/g in 2 h.

Selenium Electrophilic Center Responsive to Biological Electron Donors for Efficient Chemotherapy.

Designing drugs to intelligently respond to different ratio of biological electron donors/receptors in cancer cells and normal cells is a promising strategy to achieve highly effective and less toxic chemotherapy. Herein by employing metal center to active the selenium-containing electrophilic center drug Ru(phtpy-NO)(phenSe)Cl (RuSe) with strongly polarization characteristics are synthesized which can efficiently shuttle electrons from biological electron donors to convert to oxidative stress. The rate of electron transfer at the selenium electrophilic center is 1.

Enhanced methanogenesis and efficient ciprofloxacin degradation via nZVI@LDH in an electricity-driven anaerobic bioreactor: A biotic-abiotic hybrid system for ROS regulation and ARGs mitigation.

The escalating presence of antibiotic contaminants in wastewater presents substantial environmental and public health challenges, primarily due to their role in the proliferation of antibiotic resistance genes (ARGs). This study examines the effectiveness of a hybrid system integrating nano zerovalent iron (nZVI) and layered double hydroxides (LDH) in treating wastewater contaminated with ciprofloxacin (CIP). Reactor experiments revealed that incorporating nZVI@LDH mitigated the shock caused by CIP while sustaining a methane production rate that was 116 % higher than that of the control group.