Publications by authors named "Colin Zenge"
TOM20-driven E3 ligase recruitment regulates mitochondrial dynamics through PLD6.
Nat Chem Biol
April 2025
Mitochondrial homeostasis is maintained through complex regulatory mechanisms, including the balance of mitochondrial dynamics involving fusion and fission processes. A central player in this regulation is the ubiquitin-proteasome system (UPS), which controls the degradation of pivotal mitochondrial proteins. In this study, we identified cullin-RING E3 ligase 2 (CRL2) and its substrate receptor, FEM1B, as critical regulators of mitochondrial dynamics.
View Article and Find Full Text PDFArticle Synopsis
- The balance of neuronal ubiquitin plays a key role in managing cellular proteins and its disruption can lead to various neurological disorders.
- This article examines recent findings on how components of the ubiquitin system, particularly E3 ligases and deubiquitylases, are affected in neurodevelopmental and neurodegenerative diseases.
- It highlights advancements in understanding enzyme-substrate relationships, research using stem cell and animal models, and the development of potential treatments for diseases related to the ubiquitin system.