A Novel Morphological Classification to Guide Transcatheter Mitral Valve Edge-to-Edge Repair for Commissural Mitral Regurgitation.

Background: Mitral commissural prolapse poses significant anatomical challenges that can hinder the effectiveness of transcatheter edge-to-edge repair (TEER).

Objectives: The aim of this study was to estimate the safety and effectiveness of applying a novel morphological classification to guide TEER in patients with commissural degenerative mitral regurgitation (DMR).

Methods: In this prospective, multicenter study across 18 centers in China, we classified patients with severe commissural DMR into 4 morphological types through detailed echocardiographic analysis.

FGFC1 overcomes Ara-C resistance in acute myeloid leukemia by inducing apoptosis and pyroptosis.

Acute myeloid leukemia (AML) is a hematologic malignancy with a high mortality rate and poor prognosis, largely attributed to the emergence of chemotherapy resistance. Cytarabine (Ara-C), the cornerstone chemotherapeutic agent for AML, faces significant challenges due to the development of resistance, creating an urgent need for novel therapeutic strategies. Pyroptosis as a new form of programmed cell death has emerged as a potential therapeutic target in tumor treatment.

Stable and highly sensitive self-powered X-ray detection high-density CsPbBr-type Dion-Jacobson trilayer hybrid perovskites.

Dion-Jacobson (DJ)-type organic-inorganic hybrid perovskites have emerged as promising candidates for X-ray detection owing to their exceptional stability and remarkable X-ray absorption ability. Nevertheless, achieving enhanced detection sensitivity continues to pose a significant challenge in this research domain. Herein, we have successfully synthesized and grown a DJ-type (4-AMP)CsPbBr (1, 4-AMP = 4-ammoniomethylpiperidinium) hybrid perovskite single crystal with a high density of 3.

Construction of a Genetic Prognostic Model in the Glioblastoma Tumor Microenvironment.

Background: Glioblastoma (GBM) is one of the most challenging malignancies in all of neoplasms. These malignancies are associated with unfavorable clinical outcomes and significantly compromised patient wellbeing. The immunological landscape within the tumor microenvironment (TME) plays a critical role in determining GBM prognosis.

Highly Soluble Mussel Foot Protein and Its Derivatives Inhibit Inflammation by Targeting NF-κB/PI3K-Akt Signaling and Promoting M2 Macrophage Polarization.

Chronic inflammation is closely associated with various diseases, underscoring the need for natural, biocompatible anti-inflammatory candidates. For this purpose, mussel foot protein could be an excellent candidate due to its diverse biological activities. Hence, this study systematically evaluates the anti-inflammatory effects of a highly soluble mussel foot protein (HMFP) and HMFP-PEG using LPS-stimulated RAW264.

Hypoxanthine Promotes Pulmonary Vascular Remodeling and Adenosine Deaminase Is a Therapeutic Target for Pulmonary Hypertension.

Uric acid metabolism is implicated in the pathogenesis of pulmonary arterial hypertension, wherein the key metabolite hypoxanthine exhibits elevated levels, thereby promoting pulmonary vascular remodeling through facilitation of cell proliferation and migration as well as regulation of adenosine triphosphate binding cassette transport signaling pathway. Consequently, therapeutic interventions targeting hypoxanthine synthesis may hold promise for the management of pulmonary arterial hypertension.

Mannan-Containing Polymers from Hadal Bacterium : Preparation, Structural Analysis, Immunological Activity and Antitumor Effects.

Microbial exopolysaccharides from extreme environments are increasingly becoming valuable candidates for drug development. In this study, four fractions named XL-1, XMRS-1, XL-1-D, and XMRS-1-D were isolated and purified from the hadal bacterium by column chromatography. The structural features of these fractions were characterized by molecular weight, monosaccharide composition, Fourier transform infrared (FTIR) spectrum, amino acid analysis and NMR.

Ultrahigh Transparent and Toughness Copolymer Eutectogels via Phase Separation for Fast Tissue Clearing and 2D/3D Imaging.

Gel-based tissue clearing technologies represent a significant advancement in three-dimensional imaging. However, the challenge of achieving consistent high resolution across large tissue samples remains an issue. We present a phase-separated eutectogel constructed through radical copolymerization of acrylamide and ,-dimethylacrylamide in a eutectic solvent (antipyrine/erythritol/imidazole) (AEI/ES) with dynamically tunable polymer-solvent interactions.

Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine.

Ethnopharmacological Relevance: In Traditional Chinese Medicine (TCM), dampness is a pathogenic factor arising from impaired production and transportation of bodily fluids. While Fuling Zexie decoction (FLZXD) has demonstrated therapeutic efficacy in dampness constitution (DC) treatment, the material basis underlying its constitutional modulatory effects remains unclear.

Aim Of The Study: This study proposes objective indicators for the differentiation and therapeutic evaluation of DC and elucidates the material basis of FLZXD in DC treatment.

Targeting ZBP1-Mediated PANoptosis: Inflammation-Responsive Selenized Chitosan Nanoparticles Loaded with Moringa A for Antiviral Pneumonia Therapy.

Viral pneumonia poses a major global public health challenge, where excessive inflammatory responses contribute to tissue damage and respiratory failure. Inflammation-responsive nanoparticles can target inflamed areas, improving drug delivery while minimizing side effects. Chitosan, a biocompatible polysaccharide with anti-inflammatory and immunomodulatory properties, gains enhanced antioxidant and anti-inflammatory capabilities when combined with selenium.

Formononetin Alleviates MNNG-Triggered Chronic Atrophic Gastritis: Its Potential Mechanisms.

Background: Chronic atrophic gastritis (CAG) is the initial phase in the carcinogenesis of gastric cancer (GC). Therefore, effective treatment for CAG is important in reducing the risk of GC progression. As an isoflavone compound, formononetin (FMN) has been identified as a potential therapeutic agent for acute gastric ulcers and GC.

A water sensitive urban design (WSUD) planning framework for catchment-scale urban pluvial flood mitigation targets.

Water Sensitive Urban Design (WSUD) offers a promising solution for urban pluvial flood mitigation. While the existing target-oriented approach is effective for rapid WSUD planning for stormwater quality and quantity control, it struggles with pluvial flooding reduction objectives due to the complex interactions with stormwater drainage networks across a catchment. We propose a novel framework that advances WSUD planning for flood mitigation by generating a pool of cost-effective strategies aimed at reducing flood damage return periods.

Recombinant humanized collagen combined with nicotinamide increases the expression level of rat basement membrane proteins and promotes hair growth.

Background: Hair follicle stem cells (HFSCs) play crucial roles in hair growth and are expected to be potential targets in regenerative medicine and tissue engineering.

Method: This study aims to investigate the positive effect on hair growth by the recombinant human collagen complex (RHC complex), composed of rhCOL III, rhCOL XVII, and rhCOL XXI, along with nicotinamide, both and , by HFSCs and rat models. The survival rate, function, and differentiation of HFSCs were investigated.

Highly Soluble Mussel Foot Protein Enhances Antioxidant Defense and Cytoprotection via PI3K/Akt and Nrf2/HO-1 Pathways.

Mussel foot protein is a bioadhesive protein with potential biomedical applications, but its limited solubility and poor biological stability hinder its widespread use. In this study, highly soluble mussel foot protein (HMFP) was successfully extracted using a stepwise selective enzymatic digestion method, with a molecular weight in the range of 11-17 kDa. Furthermore, a dual-functional polyethylene glycol (PEG) derivative of HMFP, designated HMFP-PEG, was synthesized.

A novel PEGylated squid-derived protamine protein in combination with sorafenib effectively inhibits hepatocellular carcinoma growth.

In recent years, combination therapy has gained attention for improving hepatocellular carcinoma (HCC) treatment. However, the anticancer potential of marine-derived proteins combined with sorafenib remains largely unexplored. This study investigates, for the first time, the anticancer effects and mechanisms of Symplectoteuthis oualaniensis protamine (SOP), its PEG-modified form (SOP-PEG), and sorafenib in Hepa1-6 cells.

A thermoresponsive magnetic nanocarrier with the DNA-mimetic base pairing-guided controlled release of methotrexate in the treatment of rheumatoid arthritis.

Controlled drug delivery systems not only augment the therapeutic efficacy of drugs but also mitigate their adverse effects. Methotrexate (MTX) is a prominent first-line therapeutic agent in the management of rheumatoid arthritis (RA), yet it is characterized by its limited aqueous solubility, pronounced hemolytic activity, and propensity for off-target binding, which collectively contribute to its significant toxicity profile. To address these issues, a temperature-responsive controlled release system for MTX based on the analogous base pairing rule was designed for the RA treatment.

Frequency of anti-GQ1b IgG antibody in Miller Fisher syndrome: a Chinese single center study.

Background: The anti-GQ1b IgG antibody has been traditionally regarded as a sensitive marker for Miller Fisher syndrome (MFS). Nevertheless, its prevalence might vary across regions and could be affected by the coronavirus disease 2019 (COVID-19) pandemic. This retrospective study was designed to evaluate the positivity rate of the anti-GQ1b IgG antibody among MFS patients admitted to a single Chinese center and to examine the influence of the COVID-19 pandemic thereon.

Squid-derived protamine: A natural basic protein and its PEGylated derivative as anti-cancer agents in hepatocellular carcinoma.

Protamine is a naturally occurring cationic protein derived from marine organisms. Due to its unique protective and self-repairing properties, it has attracted significant attention in the biomedical field. This study investigates the anticancer effects of SOP and its PEGylated derivative (SOP-PEG) in hepatocellular carcinoma (HCC).

Special Characterization and Excellent Antioxidant Capabilities of Zinc Chelated Squid Protein Nanoparticles.

The functional exploration of marine-derived proteins is at the forefront of nutritional research. The Argentine squid protein (ASP) was extracted from Argentine squid carcasses and was hydrolyzed using neutral protease, with the degree of hydrolysis serving as the response variable. Using single-factor experiments and response surface methodology, we identified optimal conditions for preparing Argentine squid protein peptides (ASPP).

Squid Skin Decellularised Dermal Matrix for Enhancing Repair of Acute Cranial Injuries in Rabbit Model.

Squid skin decellularized dermal matrix (SADM) is gaining attention in tissue engineering and regenerative medicine due to its mimicking of the extracellular matrix property. Hence, SADM was used to investigate mimicking the microenvironment of cellular growth, inducing cellular infiltration and angiogenesis, and facilitating the repair of acute craniofacial wounds. For this, tissue regeneration membranes from squid skin were prepared by decolorization, degreasing and decellularisation methods.

[A Prospective Cohort Study on Soy Product Intake and the Risk of Lung Cancer Based on Shanghai Suburban Adult Cohort and Biobank].

Background: Lung cancer is one of the malignant cancers with the highest incidence rate, and it is important to identify the factors contributing to lung cancer carcinogenesis for prevention. Lifestyle and genetic factors play important roles in cancer development, however the impact of dietary factors, such as soy product intake, on lung cancer risk remains inadequately understood. This study aims to explore the associations between soy product intake, genetic risk, and lung cancer incidence, and validate the consistent effects of soy product intake in European populations, thereby providing new insights for lung cancer prevention.

Stem cell-mediated bone regeneration of marine-derived fibrinolytic compound (FGFC-1) loaded carboxymethyl chitosan hydrogels.

Carboxymethyl chitosan (CMC)-based hydrogels (HG) have gained significant attention for therapeutic applications due to their biomimetic properties and biocompatibility. This study explores, for the first time, the regenerative and osteogenic potential of CMC-HG incorporated with a marine fungi-derived fibrinolytic compound, FGFC-1. The inclusion of FGFC-1 did not significantly alter the crucial characteristics of the HGs, including secondary structure, thermal stability, protein adhesion, and in vitro degradation.