Rehabilitation applications and progress in managing pulmonary hypertension.

Pulmonary hypertension (PH) is a significant global health challenge that profoundly impacts exercise tolerance and quality of life for affected individuals. While advancements in pharmacological therapies have improved symptom management, exercise capacity, and overall well-being, there is a growing recognition of rehabilitation therapy as a promising non-pharmacological approach. Rehabilitation therapy aims to restore or enhance physical, psychological, and social functioning in individuals compromised by disease, injury, or congenital conditions through an integrated approach encompassing medical, social, and educational interventions.

Potential protective role of in myopia prevention: evidence from full-length 16S rRNA sequencing and bidirectional Mendelian randomization analysis.

Introduction: The increasing prevalence of myopia worldwide poses significant public health concerns. Accumulating evidence suggests a potential link between ocular diseases and the gut microbiota (GM); however, whether the GM directly contributes to myopia development remains to be established.

Methods: This study investigated the potential causal link between the GM and myopia through bidirectional Mendelian randomization (MR) analysis, further validated by experiments conducted on a form-deprivation myopia (FDM) guinea pig model.

Persistent Genomic Erosion in Whooping Cranes Despite Demographic Recovery.

Integrating in-situ (wild) and ex-situ (captive) conservation efforts can mitigate genetic diversity loss and help prevent extinction of endangered wild populations. The whooping crane (Grus americana) experienced severe population declines in the 18th century, culminating in a collapse to ~20 individuals by 1944. Legal protections and conservation actions have since increased the census population from a stock of 16 individuals to approximately 840 individuals, yet the impact on genomic diversity remains unclear.

p53 Modulates the Gut-Liver Axis via PI3K/AKT/Wnt Signaling Pathways in Type 2 Diabetes.

The p53 protein has been identified as a critical regulator of metabolic processes in a variety of diseases, including obesity, diabetes, liver disease, and cardiovascular disease. However, the precise function and mechanism of action of p53 in the regulation of glucose-lipid metabolism through the enterohepatic axis remain to be fully elucidated. The present study investigated the effects of p53 deficiency on type 2 diabetic mice and demonstrated that p53 deficiency resulted in more severe impairment of glucose tolerance and insulin tolerance.

Residue Elimination Patterns and Determination of the Withdrawal Times of Seven Antibiotics in Taihang Chickens.

Antibiotic residues in poultry pose health and resistance risks, necessitating breed-specific WDTs. In this study, the residue elimination patterns of seven antibiotics in Taihang chicken tissues under free-range conditions were studied and the appropriate WDT was formulated. A total of 240 healthy Taihang chickens aged 100 days were randomly divided into 8 groups, each comprising 30 chickens.

Keys to the global treeline formation: Thermal limit for its position and moisture for the taxon-specific variation.

Alpine treeline is a prominent biogeographic feature worldwide, determined by the physiological limit of tree life form. There are considerable variations in the various dimensions of physiological limit among tree taxa; thus, varied environmental drivers and spatial patterns are expected for different tree taxa at treelines. However, such taxonomic variability of treeline is often overlooked in large-scale studies.

Metal/TiO composite photocatalysts with tunable activity for nitrogen fixation: the impact of metal nanoparticles.

Photocatalytic N fixation reactions can harvest solar energy to convert the abundant but inert N into available NH. Nanoscale metal/semiconductor composites are among the most developed photocatalysts for the conversion, whereas systematic investigations of the impact of metal species and status on their photocatalytic performance are rarely reported. Herein, metal nanoparticle-modified TiO (M-TiO, M = Au, Pd and Cu) samples were selected as model composites for photocatalytic N fixation.

Mn doped Fe-gallate acid MOFs loaded on the surface of biomass cotton fibers: Fenton-like degradation of tetracycline.

In this study, the novel composite material was synthesized by loading Mn-doped Fe-based gallic acid metal-organic frameworks (MOFs) onto biomass cotton fibers (Mn/Fe-GA-MOFs@CF). Mn doping improved the catalytic efficiency of Fenton-like reactions. Moreover, the MOFs loading onto cotton fibers enhanced the recoverability and practical usability.

Investigating the properties of potato protein fibers and their application in oleogel -structured high internal phase emulsions.

Recently, the fiberization of protein has attracted interest as the it has the ability to improve properties of proteins. This work aimed to investigate the characteristics and mechanism of self-assembly of potato protein (PP) into protein fibers (PNFs) under certain conditions. The properties of potato protein fibers and gums (PP-PNFs/GA) were investigated.

Trajectory analysis of Mythimna Loreyi migration into Korea using the HYSPLIT model.

Migratory moth species have a negative impact on agriculture in Korea, causing economic crop losses for farming households. The moths fly a considerable distance from their origins and settle in Korea, where they live for several generational cycles, feeding and laying eggs until the arrival of cold winter hinders their overwintering. Therefore, it is important to determine the timing and location of the moths' departure and arrival to prevent potential harm from invasive moths.

Phenotypic and genotypic characterization of familial adult myoclonus epilepsy in a Chinese case series.

Familial adult myoclonus epilepsy is a type of repeat expansion disorders caused by insertion of the causative pentanucleotide TTTCA repeat into an intronic polymorphic TTTTA repeat in different genes. We aimed to characterize the clinical features and elucidate the exact genetic basis of TTTTA/TTTCA repeat expansion in familial adult myoclonus epilepsy from mainland China. Eighty-five individuals including 36 patients and 49 normal phenotype relatives from seven pedigrees with familial adult myoclonus epilepsy, were recruited in a case series from mainland China.

Clinicopathological, Genomic, and Transcriptomic Feature Analysis of Primary Adrenal Large B-cell Lymphoma: Insights Into Immune-privileged Sites.

Primary large B-cell lymphoma of immune-privileged sites (IP-LBCL) is a newly categorized disease entity in the 5th WHO Classification of Tumors. Through an analysis of 53 primary adrenal large B-cell lymphoma (PA-LBCL) cases, we unraveled the similarity to IP-LBCL in clinical presentation, pathologic features, and genetic landscape. Our findings reveal a predominant immunophenotype of CD10-/BCL6+/MUM1+ in PA-LBCL, mirroring that observed in IP-LBCL, and a shared mutation spectrum characterized by the notable presence of PIM1, MYD88 L265P, and CD79B mutations.

Impact of Storage Conditions on the Stability of Urinary Biomarkers.

Background: This study aimed to assess the influence of different storage conditions and pH levels on biomarkers in urine.

Methods: Urine samples were collected from 20 healthy individuals and 20 patients with kidney disease. The stability of nine proteins with normal and pathological concentrations was investigated under 4 types of storage conditions: 25°C for 8 hours, 4°C for 7 days, -20°C for 12 weeks, and -80°C for 12 months.

Differentiation of inflammatory pseudotumors and malignant pulmonary nodules using the time-to-peak in first-pass dual-input volume computed tomography-perfusion.

Background: Inflammatory pseudotumors (IPTs) are often misdiagnosed as malignant solitary pulmonary nodules (SPNs) because their imaging features overlap with those of malignant SPNs, leading to overtreatment. The purpose of this article was to investigate the value of first-pass enhanced time-to-peak (TTP) in distinguishing IPTs from malignant SPNs using dual-input volume computed tomography perfusion (DI-CTP).

Methods: This retrospective study included consecutive patients from No.

Biallelic Variants in EPG5 Gene Are Associated with Parkinson's Disease.

Objective: Despite substantial advancements in uncovering the genetic basis of Parkinson's disease (PD), a significant portion of cases characterized by familial PD remain genetically elusive. Here, we reported that biallelic variants in EPG5, a key autophagy gene responsible for Vici syndrome, are associated with PD.

Methods: Whole-exome sequencing (WES) was performed in the first cohort including 171 pedigrees with autosomal recessive PD (ARPD), 1,746 cases of sporadic early-onset PD (sEOPD, age at onset ≤ 50 years) and 1,652 healthy controls.

Synthesis of phospholipid vesicles using an electrokinetic turbulent microreactor.

Microfluidic-based material synthesis is uniquely suited for the fabrication of reproducible and controllable products due to the highly controlled reaction environments in microscale dimensions. With many passive and active micromixers emerging for the on-chip material synthesis needs, the use of electrokinetic driven fluid to form turbulence actuation is yet an unexplored technique with much-unrealized potential. In this study, we used an electrokinetic turbulent micromixer for the controllable synthesis of phospholipid vesicles by nanoprecipitation.

A Universal Approach to Anchoring Chromophores onto Magnetic Scaffold for Achieving Easily Recyclable Heterogeneous Photocatalytic Systems.

Photocatalysis based on chromophores such as porphyrin, coumarin, anthraquinone, and pyrene is a promising technology to achieve green synthesis of various high-value chemicals, but the robust and non-covalent immobilization of chromophores onto light-inert scaffolds for industrialization-oriented heterogeneous photocatalysis remains challenging. In this work, a simple and universal strategy is presented for preparing highly efficient and recyclable heterogeneous photocatalysts from chromophores, which is achieved via biotinylation of chromophore molecules and subsequent supramolecular binding of chromophore-biotin dyads to streptavidin-decorated magnetic beads. As an example, commercial magnetic beads modified by 5,10,15,20-tetrakis(4-aminophenyl) porphyrin not only possessed remarkable photocatalytic activities for the oxidative coupling of benzylamine derivatives and the oxidation of thioanisole derivatives with highest product yields of beyond 95% and turnover numbers approaching 10000, driven by photogenerated reactive oxygen species but also demonstrated impressive chemical stability and efficient recyclability via simple magnetic separation during 10 successive test cycles.

Influence of the "five‑in‑one" mode on complications and compliance behaviors of patients with ureteral calculi after minimally invasive surgery.

Introduction: As a clinically common urinary system disease, ureteral calculus mainly manifests as hematuria and colicky pain.

Aim: We aimed to explore the influence of the "five‑in‑one" mode on complications and compliance behaviors of patients with ureteral calculi after minimally invasive surgery.

Materials And Methods: A total of 92 participants were enrolled from among the patients hospitalized for ureteral calculi and treated with minimally invasive surgery between April 2022 and April 2023.

Taste impairment in patients with Parkinsonism.

Background: Taste impairment is a prevalent issue among individuals with idiopathic Parkinson's disease (iPD). However, understanding taste disorders among different Parkinsonism remains incomplete. Our objective was to assess the incidence and severity of taste responses to sweet, salty, sour, bitter, and umami substances in patients with iPD, progressive supranuclear palsy (PSP), and multiple system atrophy (MSA).

Influence of triflumezopyrim and triadimefon co-exposure on enzymatic activity and gene expression changes in honey bees (Apis mellifera L.).

Pollination insects frequently encounter complex mixtures of pesticides within agricultural ecosystems. However, current risk assessments for pesticides focus primarily on single agents, failing to reflect real-world conditions. Mesoionic insecticide triflumezopyrim (TFM) and triazole fungicide triadimefon (TAD) are two compounds often detected together in the environment, raising concerns over their combined toxic effects on pollinators.

Assessment of Piezo1 Expression in Urinary Exfoliated Cells as a Diagnostic Indicator for Multiple System Atrophy.

Background: Multiple system atrophy (MSA) shares clinical features with idiopathic Parkinson' s disease (iPD) and progressive supranuclear palsy (PSP), yet reliable biomarkers for differential diagnosis remain elusive.

Objectives: This study aimed to evaluate Piezo1/2 expression in urinary exfoliated cells as a potential biomarker for MSA differentiation.

Methods: Piezo1/2 expression levels were quantified in urinary exfoliated cells from 76 MSA patients, 103 iPD patients, 59 PSP patients, and 126 healthy controls (HCs) across three independent cohorts using multiple analytical techniques.

Xiayuxue Decoction Plays an Antidevelopment Role in Hepatocellular Carcinoma through Intestinal-Hepatic Axis.

Introduction: In recent years, the effect of "intestinal-hepatic axis" in tumorigenesis of hepatocellular carcinoma (HCC) has been paid more and more attention, and the imbalance of gut microbiota is closely related to the pathogenesis of HCC. The Xiayuxue decoction (XYXD) has inhibitory effect on hepatic fibrosis, but the effect of XYXD on HCC is not clear.

Methods: We induced HCC mouse model by diethylnitrosamine and CCL4.

Marine Recalcitrant Dissolved Organic Matter Gained by Processing at Sandy Subterranean Estuaries.

The sandy subterranean estuary (STE) connecting fresh groundwater to saline sea water is characterized by strong geochemical (salinity, redox, and pH) gradients, with evidence emerging for its role as a hot spot for consumption of labile substrates. This inspired us to conduct a study to evaluate whether this holds true for dissolved organic matter (DOM), especially given the still mysterious origin of marine recalcitrant DOM. Here, characterization of DOM of 21 groundwater samples (depth 1-13 m, salinity 3.

The association between dietary inflammatory index and bone health in US adolescents: Analysis of the NHANES data.

Introduction: Adolescents with a lower peak bone mineral density (BMD) and bone mineral content (BMC) have an elevated risk of osteoporosis in adulthood. The impact of diet on bone health, particularly its role in managing inflammation, which is a key factor in bone health, is gaining wider recognition. Despite evidence that anti-inflammatory diets can enhance bone health, the link between the dietary inflammatory index (DII) and bone health among US adolescents has not been thoroughly investigated.