Differentiation of inflammatory pseudotumors and malignant pulmonary nodules using the time-to-peak in first-pass dual-input volume computed tomography-perfusion.

Background: Inflammatory pseudotumors (IPTs) are often misdiagnosed as malignant solitary pulmonary nodules (SPNs) because their imaging features overlap with those of malignant SPNs, leading to overtreatment. The purpose of this article was to investigate the value of first-pass enhanced time-to-peak (TTP) in distinguishing IPTs from malignant SPNs using dual-input volume computed tomography perfusion (DI-CTP).

Methods: This retrospective study included consecutive patients from No.

Lead Causes Lipid Droplet Accumulation by Impairing Lysosomal Function and Autophagic Flux in Testicular Sertoli Cells.

Lead (Pb) is one of the most common environmental pollutants that negatively impacts male reproductive health. Thus far, the underlying molecular mechanisms of Pb-induced reproductive toxicity are still not well understood. In this study, 64 male ICR mice were given drinking water with Pb (0, 100, 200, and 300 mg/L) for 90 days.

Microcystin-LR induces neuronal damage through mitophagy defects resulted from the downregulated transcription of Scd2 by directly targeting IGF-1R.

Microcystin-LR (MC-LR), a prevalent cyanotoxin present in hazardous cyanobacterial blooms, is recognized as a neurotoxic environmental pollutant that induces brain damage and neurobehavioral deficits. However, the mechanisms underlying MC-LR-induced neurotoxicity remain unclear. This study aims to elucidate the role of mitophagy in MC-LR-induced neurotoxicity both in vitro and in vivo.

Efficacy and safety of Neurocognitive Adaptive Training for Depression combined with SSRIs for treating cognitive impairment among patients with late-life depression: a 12-week, randomized controlled study.

Background: This randomized, open-label study examined the therapeutic effects of Neurocognitive Adaptive Training for Depression (NCAT-D) combined with selective serotonin reuptake inhibitors (SSRIs) on cognitive impairment among patients with late-life depression (LLD).

Method: Study data were collected from May 5, 2021, to April 21, 2023. Outpatients who met the diagnostic criteria for major depressive disorder according to the fifth revision of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) (i.

CXCL1/IGHG1 signaling enhances crosstalk between tumor cells and tumor-associated macrophages to promote MC-LR-induced colorectal cancer progression.

Microcystin-leucine arginine (MC-LR) is a common cyantotoxin produced by hazardous cyanobacterial blooms, and eutrophication is increasing the contamination level of MC-LR in drinking water supplies and aquatic foods. MC-LR has been linked to colorectal cancer (CRC) progression associated with tumor microenvironment, however, the underlying mechanism is not clearly understood. In present study, by using GEO, KEGG, GESA and ImmPort database, MC-LR related differentially expressed genes (DEGs) and pathway- and gene set-enrichment analysis were performed.

Core network traffic prediction based on vertical federated learning and split learning.

Wireless traffic prediction is vital for intelligent cellular network operations, such as load-aware resource management and predictive control. Traditional centralized training addresses this but poses issues like excessive data transmission, disregarding delays, and user privacy. Traditional federated learning methods can meet the requirement of jointly training models while protecting the privacy of all parties' data.

Magnetic Resonance Diffusion Tensor Imaging Characterize the Hepatic Ischemia-Reperfusion Injury in an Animal Study.

Background: Hepatic ischemia-reperfusion (I/R) injury is the main cause of morbidity and mortality after hepatectomy; thus, new methods for reducing I/R injury are required. The aim of this study is to evaluate changes in the average apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in rabbits with partial hepatic I/R injury with magnetic resonance diffusion tensor imaging (DTI).

Methods: The left lobe of the rabbit liver underwent 60 minutes of ischemia followed by 0.

Mono-(2-ethylhexyl) Phthalate (MEHP)-Induced Telomere Structure and Function Disorder Mediates Cell Cycle Dysregulation and Apoptosis via c-Myc and Its Upstream Transcription Factors in a Mouse Spermatogonia-Derived (GC-1) Cell Line.

As a typical environmental endocrine disrupting chemical (EDC), di-(2-ethylhexyl) phthalate (DEHP) is thought to be related to reproductive disorders, especially in males. Growing evidence suggests that various EDCs may result in an impaired telomere structure and function, which is associated with male infertility. However, the adverse effect of DEHP on telomeres in male reproductive cells has rarely been studied, and the related mechanisms remain unclear.

Early diagnosis of retinal neurovascular injury in diabetic patients without retinopathy by quantitative analysis of OCT and OCTA.

Aims: To quantitatively analyze and compare the differences in retinal neurovascular units (NVUs) between healthy individuals and patients with type 2 diabetes mellitus (DM) by optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) techniques and to determine the value of this technique for the early diagnosis of retinal neurovascular damage in patients with diabetes mellitus without retinopathy (NDR).

Methods: This observational case‒control study was conducted from July 1, 2022, to November 30, 2022, at the outpatient ophthalmology clinic of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine. All subjects underwent baseline data entry and mean thickness of the peripapillary retinal nerve fiber layer (pRNFL), the thickness of each retinal layer in the macula 3 × 3 mm, and vascular density (VD) examination.

An optimized method for intratracheal instillation in mice.

Non-invasive intratracheal instillation is an important method for direct exposure of the respiratory tract which is commonly used in toxicology, environmental science, and other research fields. However, there is no standard operating process for non-invasive intratracheal instillation. To keep the reliability and accuracy of intratracheal instillation is vital, especially, for animal models of sub-chronic or chronic exposure which may need repeated operations performed on many animals.

Bioinformatics analysis of the clinical significance of HLA class II in breast cancer.

Human leukocyte antigen (HLA) class II plays critical roles in antigen presentation and the initiation of immune responses. However, the correlation between the HLA class II gene expression level and the survival of patients with breast cancer is still under investigation. We analyzed microarray and RNA-Seq data of breast cancer from the cancer genome atlas (TCGA), genotype-tissue expression (GTEx) and Oncomine databases by using bioinformatics tools.

The effect of MWA protocols upon morphology and IVIM parameters of hepatic ablation zones-a preliminary in vivo animal study with an MRI-compatible microwave ablation device.

PURPOSE We aimed to explore the effect of microwave ablation (MWA) protocols upon morphology and instant changes in intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) parameters on MWA zones in porcine livers. METHODS According to the empirical protocol for MWA in tumors less than 3 cm in our hospital, the power and application duration were assigned as five groups: A, 60 W × 5 min (n = 6); B, 80 W × 3 min (n = 7); C, 80 W × 5 min (n = 10); D, 100 W × 3 min (n = 10); E, 100 W × 5 min (n = 9). Spearman correlation between MWA protocols, morphological metrics, and instant post-ablation IVIM parameters was performed.

Nerve Growth Factor Promotes Retinal Neurovascular Unit Repair: A Review.

The purpose of this paper is to investigate how the imbalance of neurogenic factor (NGF) and its precursor (pro-NGF) mediates structural and functional impairment of retinal neurovascular unit (RNVU) that plays a role in retinal degenerative diseases. A literature search of electronic databases was performed. The pro-apoptotic effect of pro-NGF and the pro-growth effect of NGF are essential for the pathological and physiological activities of RNVU.

Gender differences in outpatients with dementia from a large psychiatric hospital in China.

Background: The sociodemographic characteristics and clinical features of dementia patients in psychiatric hospitals have not been thoroughly studied in China. This study aimed to explore the psychiatric outpatient attendance of dementia patients at a psychiatric hospital in China, with particular emphasis on gender differences.

Methods: This retrospective study examined outpatients with dementia from January 2013 to August 2019 using data in the Observational Medical Outcomes Partnership Common Data Model (OMOP-CDM) in Beijing Anding Hospital.

Comparing Screening Abilities of the 33-Item Hypomania Checklist (HCL-33) and the 33-Item Hypomania Checklist External Assessment (HCL-33-EA) for the Detection of Bipolar Disorder.

Bipolar disorder (BD) is a severe psychiatric disorder that is often misdiagnosed and under-diagnosed in clinical settings. The 33-item Hypomania Checklist (HCL-33) is a newly developed self-administered scale for BD detection, while the 33-item Hypomania Checklist-external assessment (HCL-33-EA) is a version of the HCL-33 for external rating used by patient's carer (e.g.

Mingjing granule, a traditional Chinese medicine in the treatment of neovascular age-related macular degeneration: study protocol for a randomized controlled trial.

Background: Neovascular age-related macular degeneration (nAMD) is the most common cause of irreversible vision loss and blindness among the older people aged 50 and over. Although anti-vascular endothelial growth factor (anti-VEGF) therapies have resulted in improving patient outcomes, there are limitations associated with these treatments. In China, traditional Chinese medicine (TCM) has been used to treat eye diseases for more than 2000 years.

Characterization of the complete chloroplast genome of a common Chinese medicinal herb, (Eriocaulaceae: ).

is a common Chinese medicinal herb and belongs to the family Eriocaulaceae genus Eriocaulon the annual herbs. In this study, the complete chloroplast genome of was assembled and reported. The complete chloroplast genome of is 157,016 bp in length as the circular, which harbours a large single-copy region (LSC) of 81,534 bp, a small single-copy region (SSC) of 17,114 bp, and two inverted-repeat regions (IRs) of 26,393 bp each one.

Theoretical studies on the bond strength and electron density characteristics in multiple hydrogen bonded arrays.

Multipoint hydrogen bonded motifs with intermolecular N-H⋯N hydrogen bonds have been theoretically studied at the PBE0-D3/ma-def2-TZVP level. The properties of electron density at the bond critical points of hydrogen bonds have been analyzed through "atoms in molecule" (AIM) theory and "electron localization function" (ELF) method. The results imply that the secondary electrostatic interactions have a significant effect to the strength of multipoint hydrogen bonds.

1,25-dihydroxyvitamin-D3 promotes neutrophil apoptosis in periodontitis with type 2 diabetes mellitus patients via the p38/MAPK pathway.

Background: Abnormal neutrophils are involved in many chronic endocrine diseases, including type 2 diabetes mellitus (T2DM), and in periodontitis (PD), which is a chronic inflammatory disease in which neutrophils play a vital role. The p38 mitogen-activated protein kinase (MAPK) signaling pathway participates in the apoptosis of many inflammatory cells. Additionally, 1,25-dihydroxyvitamin-D3 (1,25VitD3) as a regulator can induce responses to infection and tumor cell apoptosis.

Can intravoxel incoherent motion diffusion-weighted imaging characterize the cellular injury and microcirculation alteration in hepatic ischemia-reperfusion injury? An animal study.

Purpose: To investigate whether intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) can be used to quantitatively analyze the cellular injury and microcirculation alterations in hepatic ischemia-reperfusion injury (HIRI).

Materials And Methods: Thirty-two New Zealand white rabbits were randomly and equally assigned to the sham group, 1-hour, 4-hour, and 12-hour groups according to the reperfusion time after 1 hour of ischemia using a 70% liver ischemia-reperfusion injury model. All the animals underwent IVIM-DWI with 12 b values at 1.

Perfusion computed tomography evaluation of partial hepatic ischemia reperfusion in a rabbit model.

Rationale And Objectives: An animal model of partial hepatic ischemia/reperfusion injury (I/R) has benefits for decision making and clinical management after liver transplantation or massive hepatic resection. The aim of this study was to evaluate the change in perfusion parameters after partial hepatic I/R in rabbits using multislice computed tomography perfusion imaging.

Materials And Methods: Thirty rabbits underwent 60 minutes of left hepatic lobar ischemia followed by 0.

[Optimization of the scan delay time of 64-slice spiral CT portal venography].

Objective: To optimize scan delay time of multi-slice spiral CT portal venography (MSCTP) using test bolus injection.

Methods: Sixty individuals with no hepatic diseases were randomly divided into 4 groups (A, B, C and D). The time-density curves (TDC) of the portal vein (PV) were acquired by test bolus (15 ml, 5 ml/s) at the level of liver hilus.