Enhancing Neural Representations of Motor Imagery through Action-Specific Brain Connectivity Patterns.

Motor imagery (MI) is a cognitive process that allows individuals to mentally simulate movements without physical execution. However, the exploration of functional connectivity (FC) and lateralization mechanisms under different MI actions remains insufficiently understood. In this work, the common orthogonal basis extraction (COBE) algorithm was employed to isolate action-specific components by removing shared background components from the raw FC of the MI process.

Integration of transcriptomics and metabolomics reveals the mechanism of Glycyrrhizae Radix Et Rhizoma extract inhibiting CCL5 in the treatment of acute pharyngitis.

Background: Acute pharyngitis (AP) is a common condition marked by inflammation of the oropharynx, which can lead to severe throat swelling, breathing difficulties, and even suffocation, significantly impacting quality of life. Despite the beneficial anti-inflammatory activity of Glycyrrhizae Radix Et Rhizoma (GRER) and Isoliquiritigenin (ISL), their pharmacological mechanisms against AP remain unclear.

Purpose: This study explores the mechanisms by which GRER treats AP, utilizing both transcriptomics and metabolomics approaches.