Nanomedicine Targeting the Warburg Effect: Advanced Strategies for Cancer Therapy.

Cancer remains the foremost cause of mortality globally, characterized by un-controlled cellular proliferation driven by oncogenic mutations and other factors. These mutations disrupt cellular homeostasis, leading to a spectrum of adverse physiological responses. A key feature of cellular metabolism in cancer is the Warburg effect, in which cancer cells preferentially rely on glycolysis for ATP production, even in the presence of oxygen, to meet their elevated metabolic demands.

Retrospective Analysis of Factors Associated With Increased Anesthesia Ready Time in Patients With Odontogenic Infections.

Background: Airway management in patients with odontogenic infections presents a known challenge. The current study aims to identify factors associated with anesthesia ready time (ART) and first-attempt intubation failure (FAIF) in patients with odontogenic infections.

Methods: In a retrospective cohort study, subjects 14 years and older between January 1, 2012, and December 31, 2019, requiring incision and drainage for odontogenic infections under general anesthesia were included.

Smart textile interfaces based on protein structure-reconstructed bovine serum albumin hydrogel fibers for disability support.

Human-machine interaction (HMI) textile interfaces with safe ingredients for intelligent wearable sensing systems are critical in the era of information and the metaverse. To address the dual limitations of traditional synthetic polymer hydrogels (poor biocompatibility) and pure protein-based materials (limited mechanical performance), this study has redesigned the protein structure for a bovine serum albumin (BSA)-based composite hydrogel fibers system. By leveraging the synergistic interplay of dynamic ionic crosslinking and covalent crosslinking, the hydrogel system achieves enhancements in both mechanical strength and processability.

Controlling Nosocomial Transmission of Respiratory Infections in Neurological Wards: Insights from COVID-19 Pandemic Data.

Background: Transmissible diseases pose significant risks within healthcare facilities, which can lead to accelerated viral spread and exacerbate healthcare burdens, particularly for patients with severe conditions. During the COVID-19 pandemic, numerous cases of nosocomial infections were reported, underscoring the shortcomings of current in-hospital management strategies for controlling such outbreaks. This study aims to provide insights for developing improved in-hospital management strategies for future infectious disease outbreaks.

Modulation of potato starch gelatinization, rheological properties, and mechanical properties: the role of potato soluble dietary fiber with different molecular weights.

This study investigated the effect of the molecular weight (Mw) of potato soluble dietary fiber (PSDF) on potato starch (PS) gelatinization. Crude PSDF delayed gelatinization, and significantly improved the viscoelasticity and structure orderliness of the gel. However, PSDFs of different Mws had different effects on these physicochemical properties of PS.

Hyperglycemia-Reduced Platelet-Derived Growth Factor-BB Expression Impairs Corneal Wound Healing in Diabetic Mice.

Purpose: This study investigates the role and primary mechanisms of platelet-derived growth factor-BB (PDGF-BB) in regulating corneal epithelial injury repair and nerve regeneration under diabetic conditions.

Methods: Type 1 diabetes was induced in C57BL/6 mice via streptozotocin injection. Platelet depletion was achieved using an anti-mouse GPIbα antibody.

Clinical Characteristics and Influencing Factors of Postoperative Pain in Patients Undergoing Gastric Endoscopic Submucosal Dissection.

Background: To comprehensively analyze the clinical characteristics of patients who underwent gastric endoscopic submucosal dissection (ESD) and explore the incidence and influencing factors of postoperative pain.

Methods: The clinical data of patients who underwent gastric ESD at our center from 2009 to 2024 were retrospectively analyzed. Pain severity was assessed using a visual analogue scale, with a score ≥ 4 defined as postoperative pain.

Exploring the hepatoprotective effects of perillyl alcohol in the experimental models of acute liver injury.

Aims: Acute liver injury (ALI), a severe and potentially fatal inflammation-mediated process of hepatocellular damage, remains a critical clinical concern. The goal of this study was to investigate the protective effects of Perillyl alcohol (POH), a naturally occurring monoterpene with potent anti-inflammatory properties, on LPS/D-GalN-induced ALI in both in vivo and in vitro models.

Materials And Methods: In this study, POH was used as a pretreatment to assess its effects on ALI.

Cruciferous Vegetables, Bioactive Metabolites, and Microbiome for Breast Cancer Prevention.

Breast cancer is a heterogeneous disease with varying subtypes, prognoses, and treatment responses. Cruciferous vegetables have shown promise in reducing breast cancer risk. This review discusses () the efficacy of sulforaphane (SFN) and indole-3-carbinol (I3C)/3,3'-diindolylmethane (DIM) on breast cancer risk, prognosis, and treatment outcomes in recent human studies through 2024; () preclinical studies (2018-2024) that evaluate the efficacy and synergism of SFN, DIM, and other phytochemicals with conventional breast cancer treatments as promising combination therapy strategies for validation in future clinical trials; and () the role of the microbiome in breast cancer and the interaction between interindividual variations in gut microbiome and glucosinolate metabolism that could modify the benefits of cruciferous vegetable consumption and breast cancer treatment efficacy.

Innovative nanocarriers: Synthetic and biomimetic strategies for enhanced drug delivery.

Effective drug delivery plays a vital role in the treatment of various biomedical conditions. Application of innovative nanocarriers could address issues faced in drug delivery such as poor drug distribution, inefficient penetration across biological barriers, targeting and security. With the development of nanotechnology, the preparation approaches, structures and properties of nanocarriers are continuously improving, while the comparison of detailed construction strategies and corresponding innovative application of different nanocarriers for enhanced drug delivery are few.

Downregulating Cdk5 reverses hippocampal neuron ferroptosis by regulating the AMP-activated protein kinase pathway and "M1" polarized microglia.

Aberrant activation of microglia plays a crucial role in neuronal injury after ischemic stroke. Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine-directed kinase that plays a significant role in neuronal damage. We investigated the role of Cdk5 in microglial activation and neuronal ferroptosis in cellular and animal models of hypoxic-ischemic neuronal injury.

An Investigation into the Evolutionary Characteristics and Expression Patterns of the Basic Leucine Zipper Gene Family in the Endangered Species Under Abiotic Stress Through Bioinformatics.

The gene family play a crucial role in plant growth, development, and stress responses, functioning as transcription factors. While this gene family has been studied in several plant species, its roles in the endangered woody plant remain largely unclear. This study comprehensively analyzed the gene family in , identifying 71 genes distributed across all 12 chromosomes.

New molecular diagnostic targets for Avibacterium paragallinarum and a set of single-plex and multiplex qPCR methods for the rapid differential diagnosis of Mycoplasma gallisepticum, Mycoplasma synoviae, and Avibacterium paragallinarum.

Mycoplasma gallisepticum (MG), Mycoplasma synoviae (MS), and Avibacterium paragallinarum (APG) are respiratory-borne bacterial pathogens that severely harm the poultry industry. The clinical symptoms caused by them share many similarities, such as respiratory disease, growth retardation, and decreased egg production. They are not suitable for rapid diagnosis through isolation and culture and often need to detect nucleic acids or antibodies for differential diagnosis.

SD49-7 attenuates cardiac hypertrophy by upregulation of S100B through KDM4A inhibition.

Cardiac hypertrophy is a major contributor to heart failure, yet therapeutic options remain limited. Emerging evidence suggests that upregulated expression of histone lysine-specific demethylase 4A (KDM4A) in patients with cardiac hypertrophy may represent a significant, albeit underappreciated, disease risk factor; however, the underlying mechanism and specific downstream pathway remain unclear. In this study, we investigated the therapeutic effect of SD49-7, a specific KDM4A inhibitor, on cardiac hypertrophy and its underlying mechanism, utilizing both in vivo and in vitro models.

The role of endoplasmic reticulum stress in BPS-induced disruption of endometrial decidualization.

Bisphenol A (BPA) exposure has been widely associated with adverse health outcomes, prompting the proliferation of "BPA-free" products. However, substitutes such as bisphenol S (BPS) are now equally prevalent and frequently detected at levels comparable to BPA. Our previous research identified BPA as an endocrine disruptor impairing reproductive systems.

Effects of traditional fitness qigong exercise on frailty status and overall well-being in frail or pre-frail patients: a systematic review and meta-analysis.

Objective: This study aimed to assess the effectiveness of traditional Chinese Fitness qigong exercises (TFQs) in enhancing outcomes such as frailty status, physical function, psychological well-being, cognitive function, negative emotions, and sleep quality for older adults with frailty or pre-frailty.

Methods: We conducted searches in Embase, Cochrane Library, PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang, Chinese Technical Periodicals (VIP), and Google Scholar from their inception to 30th July 2024. Two reviewers independently selected and screened the papers, extracted the data, and assessed the bias risk.

Dual-Protein Network Hydrogel-Enabled Wireless Respiratory Sensing System.

Real-time monitoring of respiration plays a crucial role in assessing human health. However, traditional respiratory monitoring devices face several challenges, such as safety concerns, poor mechanical properties, and low portability, which limiting their use in everyday portable applications. In this study, a dual-protein network hydrogel, composed of bovine serum albumin (BSA) and silk fibroin (SF), was developed using thiol-ene click chemistry and enzymatic cross-linking.

Identifying Sociodemographic Disparities in Negative Cancer Beliefs and Health-Information-Seeking Attitudes Among Oregonians.

BackgroundBeliefs and perceptions about cancer risks and accessibility of health information play an important role in influencing cancer screening behaviors and various health outcomes. However, these beliefs and attitudes are not well understood, especially across different racial and socioeconomic groups. The aim of this study was to identify sociodemographic factors associated with cancer risk perceptions and health-information-seeking attitudes among adults.

Predicting the mechanisms and targets of PFOA nephrotoxicity via network toxicology, Mendelian randomization, molecular docking and molecular dynamics simulation.

Objectives: Perfluorooctanoic acid (PFOA), widely used in food-contact materials, industrial coatings, and other applications, enters the food chain air, soil, and water, posing a potential public health risk.

Methods: This study employs network toxicology, Mendelian randomization, molecular docking and molecular dynamics simulation to preliminarily elucidate the mechanisms by which PFOA's toxic targets contribute to renal impairment. Through integrated analysis of multi-database bioinformatics, we identified 85 cross-targets associated with PFOA-induced renal toxicity.

RPL6 Interacts with HMGCS1 to Stabilize HIF-1α by Promoting Cholesterol Production in Hepatocellular Carcinoma.

The identification of predictive markers to determine the premetastatic phase before metastasis is critical for developing effective strategies for early detection and prevention. By applying the dynamic network biomarker (DNB) approach to analyze time-series transcriptomic data from a pulmonary metastasis HCC mouse model, it is revealed that the premetastatic phase occurred during the fourth week after implantation. A total of 142 DNB genes are identified as functionally important biomarkers for HCC metastasis, among which 60S ribosomal protein L6 (RPL6) is a core DNB member.

FTO-mediated mA demethylation regulates IGFBP3 expression and AKT activation through IMP3-dependent P-body re-localisation in lung cancer.

Lung cancer remains one of the leading causes of cancer-related deaths worldwide, and a growing body of evidence suggests that RNA modifications, including methylation, play a critical role in its progression. In this study, we investigated the role of the RNA demethylase fat mass and obesity-associated protein (FTO) in lung cancer progression and determined the underlying molecular mechanisms. FTO expression was significantly upregulated in LUAD and correlated with poor prognosis.

Tumor metabolome remolded by low dose mitochondrial uncoupler elicites robust CD8 T cell response.

Tumor cells balance ATP production and carbon skeleton synthesis by flexibly altering catabolic pathways to sustain their significant growth advantage. Uncouplers have shown potential for tumor suppression by converting chemical energy from catabolism into heat. However, their use may be limited due to indiscriminate metabolic interference in both tumor and normal cells, as well as the uncertainty surrounding their effects on the immune microenvironment.

ceRNA Profiling Reveals circSAMD4A Promoted Porcine Adipocytes Differentiation via Targeting miR-127/PRKAR2B.

Pork quality is critically influenced by fat deposition patterns, with emerging evidence implicating circular RNAs (circRNAs) as key regulators of adipogenesis, though the specific circRNAs controlling lipogenesis remain incompletely characterized. To systematically elucidate the competing endogenous RNA (ceRNA) network governing porcine adipocyte differentiation, we isolated primary preadipocytes from piglets, induced differentiation, and performed comprehensive RNA sequencing that identified 504 differentially expressed (DE) circRNAs, 126 DE miRNAs, and 1615 DE mRNAs between proliferative and differentiated states, revealing an extensive transcriptomic rewiring during adipogenesis. Functional characterization demonstrated that two circRNAs, circSAMD4A and circLPAR1, significantly promoted lipid accumulation.

Unraveling the therapeutic mechanisms of Bufei Yiqi decoction in pulmonary fibrosis: Modulation of autophagy and glycolysis pathways.

Pulmonary fibrosis (PF) is a chronic, progressive lung disease marked by excessive collagen deposition and inflammation. Bufei Yiqi Decoction (BFYQD), a traditional Chinese herbal formula, has shown potential in treating PF, but its mechanisms remain unclear. This study aimed to explore BFYQD's therapeutic effects on PF, focusing on its regulation of glycolysis and autophagy via the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) pathway, providing a foundation for its clinical application.

Pathophysiological Mechanisms Underlying Sarcopenia and Sarcopenic Obesity: A Systematic Review and Meta-Analysis of Biomarker Evidence.

Sarcopenia and sarcopenic obesity (SO) represent significant age-related muscular disorders. Their specific biomarkers and pathophysiological mechanisms remain insufficiently elucidated. This study aims to identify differential and shared biomarkers between these conditions to reveal distinct pathophysiological processes, providing a foundation for precision diagnostics and targeted interventions.