98%
921
2 minutes
20
Effective drug delivery plays a vital role in the treatment of various biomedical conditions. Application of innovative nanocarriers could address issues faced in drug delivery such as poor drug distribution, inefficient penetration across biological barriers, targeting and security. With the development of nanotechnology, the preparation approaches, structures and properties of nanocarriers are continuously improving, while the comparison of detailed construction strategies and corresponding innovative application of different nanocarriers for enhanced drug delivery are few. In this review, innovative nanocarriers including synthetic nanocarriers with different shapes and biomimetic nanocarriers inspired by different biological sources are introduced. Moreover, the multi-functionalities and advancements of nanocarriers in drug delivery are intensively discussed. Finally, we outline the current limitations and future perspectives of nanocarriers efforts in drug delivery, with a focus on their key challenges from bench to bedside.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12362117 | PMC |
http://dx.doi.org/10.1016/j.mtbio.2025.102180 | DOI Listing |
Macromol Biosci
September 2025
IMEM-BRT Group, Departament d'Enginyeria Química, EEBE, Universitat Politècnica de Catalunya, Barcelona, Spain.
This study investigates a multifunctional hydrogel system integrating carboxymethyl cellulose (CMC) in a 3D-printed limonene (LIM) scaffold coated with poly(3,4-ethylenedioxythiophene): polystyrene sulfonate (PEDOT:PSS). The system allows to enhance wound healing, prevent infections, and monitor the healing progress. CMC is crosslinked with citric acid (CA) to form the hydrogel matrix (CMC-CA), while the 3D-printed limonene (LIM) scaffold is embedded within the hydrogel to provide mechanical support.
View Article and Find Full Text PDFMacromol Rapid Commun
September 2025
Key Laboratory of Textile Science & Technology, College of Textiles, Ministry of Education, Donghua University, Shanghai, China.
Persistent bacterial infections remain a major challenge in wound management. Although drug-loaded wound dressings have gained increasing attention, their therapeutic efficacy is often hindered by uncontrolled drug release and a lack of electrical signal responsiveness. Herein, an antibacterial dressing (CCS-PC) with electroactivity and stimulus-responsive drug release properties was fabricated via electro-assembly, wherein chitosan and ciprofloxacin hydrochloride (CIP) were co-deposited onto polypyrrole (PPy)-coated gauze.
View Article and Find Full Text PDFDrug Dev Ind Pharm
September 2025
Department of Pharmaceutics, Mallige College of Pharmacy, Silvepura, Bangalore -560090.
ObjectivesThis review aims to explore gelling drug delivery systems with emphasis on formulation strategies, gelation mechanisms, administration routes, and therapeutic benefits. It also seeks to understand the role of different polymers in achieving optimal gelation and drug release profiles. Additionally, the review aims to identify current research gaps and highlight potential areas for future development and clinical translation.
View Article and Find Full Text PDFBiomacromolecules
September 2025
State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, China.
Triple-negative breast cancer (TNBC) remains a formidable clinical challenge due to its aggressive behavior, lack of therapeutic targets, and poor prognosis. The PI3K/AKT/mTOR pathway is highly activated in TNBC, making it a promising therapeutic target. Conventional PEGylated nanocarriers often face challenges, such as accelerated blood clearance and lysosomal trapping.
View Article and Find Full Text PDFJ Am Chem Soc
September 2025
Nanochemistry Department, Max Planck Institute for Solid State Research, Heisenbergstraße 1, 70569 Stuttgart, Germany.
Covalent organic frameworks (COFs) have been emerging as versatile reticular materials due to their tunable structures and functionalities, enabled by precise molecular engineering at the atomic level. While the integration of multiple components into COFs has substantially expanded their structural complexity, the strategic engineering of diverse functionalities within a single framework the random distribution of linkers with varying lengths remains largely unexplored. Here, we report a series of highly crystalline mixed-length multivariate COFs synthesized using azobenzene and bipyridine as linkers, where tuning the ratio of linkers and incorporating palladium effectively modulates the balance between near-infrared (NIR) light absorption and catalytic sites for NIR-generation of hydrogen peroxide (HO).
View Article and Find Full Text PDF