The role of endoplasmic reticulum stress in BPS-induced disruption of endometrial decidualization.

Bisphenol A (BPA) exposure has been widely associated with adverse health outcomes, prompting the proliferation of "BPA-free" products. However, substitutes such as bisphenol S (BPS) are now equally prevalent and frequently detected at levels comparable to BPA. Our previous research identified BPA as an endocrine disruptor impairing reproductive systems.

Downregulation of FASN in granulosa cells and its impact on ovulatory dysfunction in PCOS.

Background: Polycystic ovary syndrome (PCOS) is a complicated endocrinological and anovulatory disorder in women. Mice exposed to dihydrotestosterone (DHT) exhibit a PCOS-like phenotype characterized by abnormal steroid hormone production and ovulation dysfunction. The present investigation aims to identify overlapping genes expressed in PCOS patients and a PCOS mouse model induced by DHT and to examine the function of key genes fatty acid synthase (FASN) in hormone production and ovulation dysfunction.

Multi-modality imaging technologies and machine learning for non-invasive, precise assessment of rabbit endometrium.

Developing a minimally invasive, real-time diagnostic tool to accurately assess endometrial conditions is critical to increasing pregnancy rates in assisted reproductive technology (ART). In this research, fiberoptic bronchoscopy and optical coherence tomography (OCT) were used before and after alcohol injury and human chorionic gonadotropin (hCG)-induced pseudopregnancy to monitor changes in the rabbit endometrium. Histological analysis and electron microscopy were performed on 1 cm uterine sections while simultaneously training a conditional generative adversarial network (cGAN) to convert OCT images into virtual hematoxylin and eosin H&E stained sections.