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Studying the temporal and spatial variation characteristics and driving factors of carbon reserves in the middle reaches of the Yellow River is crucial for achieving sustainable development and regional ecological conservation against the backdrop of the "double carbon" plan. Based on the five-year interval, the land use data of the middle reaches of the Yellow River from 2000 to 2020 were selected, and the spatio-temporal evolution characteristics of carbon reserves were estimated and analyzed by coupling with the PLUS-InVEST-GeoDetector model, and the driving factors affecting the spatio-temporal differentiation of carbon reserves were discussed. Finally, the carbon reserves of the middle reaches of the Yellow River in 2030 were predicted under four developmental scenarios: natural development, ecological protection, economic development, and cultivated land protection. The findings indicate that: ① The middle reaches of the Yellow River's carbon storage showed a consistent growth trend between 2000 and 2020, exhibiting an increase by 5.75×10 t. The evolution of the spatial distribution was reasonably stable, exhibiting the characteristics of "southeast is higher than northwest." ② The middle reaches of the Yellow River's carbon storage differentiated both spatially and temporally between 2000 and 2020, with two-factor enhancement and nonlinear enhancement observed in the interaction detection of each driving element. The main driving force was the NDVI. ③ From 2020 to 2030, the carbon storage of the four scenarios in the Yellow River's middle reaches showed an increasing trend in comparison to that in 2020. Of them, the carbon storage of the ecological preservation scenario rose the highest at 3.93×10 t, while the carbon storage of the economic growth scenario increased the least at 4.8×10 t. The findings of the study will offer some evidence in favor of the middle reaches of the Yellow River's long-term development and ecological environment management.
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http://dx.doi.org/10.13227/j.hjkx.202406176 | DOI Listing |
JAMA Netw Open
September 2025
Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Importance: Patients with advanced cancer frequently receive broad-spectrum antibiotics, but changing use patterns across the end-of-life trajectory remain poorly understood.
Objective: To describe the patterns of broad-spectrum antibiotic use across defined end-of-life intervals in patients with advanced cancer.
Design, Setting, And Participants: This nationwide, population-based, retrospective cohort study used data from the South Korean National Health Insurance Service database to examine broad-spectrum antibiotic use among patients with advanced cancer who died between July 1, 2002, and December 31, 2021.
CNS Drugs
September 2025
Global Health Neurology Lab, Sydney, NSW, 2150, Australia.
Acute ischemic stroke (AIS) remains a leading cause of mortality and long-term disability globally, with survivors at high risk of recurrent stroke, cardiovascular events, and post-stroke dementia. Statins, while widely used for their lipid-lowering effects, also possess pleiotropic properties, including anti-inflammatory, endothelial-stabilizing, and neuroprotective actions, which may offer added benefit in AIS management. This article synthesizes emerging evidence on statins' dual mechanisms of action and evaluates their role in reducing recurrence, improving survival, and mitigating cognitive decline.
View Article and Find Full Text PDFKhirurgiia (Mosk)
September 2025
Saint Petersburg State University, Saint Petersburg, Russia.
Objective: To evaluate diagnostic significance of IL-6 compared to CRP for early detection of anastomotic leakage after colon resection for colorectal cancer.
Material And Methods: The study included 277 patients who underwent total resection for colorectal cancer. Patients were retrospectively divided into three groups: without complications (=227), with anastomotic leakage (=30), and other postoperative complications (=20).
Cancer
September 2025
Thoracic Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, New York, USA.
Background: Trials of neoadjuvant chemoimmunotherapy (chemoIO) have changed the standard of care for resectable nonsmall cell lung cancer (NSCLC). This study characterizes the outcomes of off-trial patients who received treatment with neoadjuvant chemoIO.
Methods: The authors analyzed records of patients with stage IB-III NSCLC who received neoadjuvant chemoIO with an intent to proceed to surgical resection at three US academic institutions.
Radiology
September 2025
Department of Magnetic Resonance Imaging, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Background MRI-derived arrhythmogenic substrate, including late gadolinium enhancement (LGE) and extracellular volume fraction (ECV), is indicative of sudden cardiac death (SCD) risk in nonischemic dilated cardiomyopathy (DCM). The relative prognostic value of LGE and ECV remains unclear. Purpose To evaluate the performance of LGE and T1 mapping in predicting SCD in patients with DCM and to explore clinical implementation.
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