Synergistic Coupling of Interfacial Oxidation Sites and S-Scheme Heterojunction in CuWS@SnInS Core-Shell Nanocomposites Boosting CO Photoreduction Efficiency.

Photocatalytic CO reduction offers a dual solution to mitigate the energy crisis and reduce carbon emissions. In situ synthesis of the CuWS@SnInS (CWS@SIS) composite has established S-S bonds at the interface, which act as atomic-scale interfacial "bridges" to stabilize the heterojunction interface. SnInS nanosheets are uniformly dispersed on the CuWS surface, activating the (101) crystal plane of CuWS to consume photogenerated holes.

Non-linear relationship between liver fibrosis and femoral neck bone mineral density in metabolic dysfunction-associated fatty liver disease patients with type 2 diabetes mellitus.

Aim: While both metabolic dysfunction-associated fatty liver disease (MAFLD) and osteoporosis are closely linked to metabolic disorders, their relationship remains controversial. This study aimed to investigate the association between liver fibrosis and femoral neck bone mineral density (BMD) in MAFLD patients with type 2 diabetes mellitus (T2DM-MAFLD) and to evaluate metabolic influences.

Materials And Methods: We retrospectively enrolled 569 hospitalized T2DM-MAFLD patients between September 2018 and May 2021.

Enhanced hydrophobicity of the current collector modifier for Zn anode endows improved longevity.

Though zinc-ion batteries have gained intensive attention recently, their application prospects have long been hampered by Zn dendrite evolution and water-involved side reactions, especially for thin and highly utilized Zn anodes. Coating a modified layer on the current collector is a common strategy to improve the reversibility of Zn plating/stripping. Hydrophilic modifier with high zincophilicity, usually affords uniform Zn deposition but exhibits intrinsic limitations in repelling water molecules, while hydrophobic modifiers shows excellent water-resistance.

Secure set-membership formation of multi-agent systems via an anti-attack control strategy.

Secure leader-following formation for multi-agent systems subject to parameter perturbations and saturation constraints is investigated in this article. To capture the variation of attack behaviors across different stages, a more general DoS attack model is developed using a Markov process with time-varying transition probabilities. Then, a memory-based anti-attack scheme is presented for designing the secure observer-based controller, supplying an effective method to weaken the impact of DoS attacks on formation control.

Parvalbumin interneurons are essential for tonotopy strength in the auditory cortex.

Tonotopy, the spatial organization of neurons based on their sound frequency responses, is a fundamental feature of the auditory pathway, extending from the cochlea to the auditory cortex. While excitatory neurons have been considered necessary for tonotopy in the cortex, the role of inhibitory interneurons remains unclear. Using a novel two-channel widefield Ca imaging system, the 2-Channel Alternating exposure wide-Field Explorer (2-CAFE), we simultaneously measured the sound responsiveness of distinct neuron types in awake mice.

Effects of lifestyle intervention by a nurse-led app on the prevention of symptoms in postpartum women: a randomized controlled trial.

Background: The incidence of postpartum symptoms such as prolonged lochia, constipation, fatigue, and depression remains high. Providing postpartum lifestyle interventions, including diet and exercise supervision, in clinical practice is challenging. A nurse-led app through diet supervision, exercise supervision and health education is a promising approach to lifestyle intervention.

Geometric amplitude assisted beamforming in transverse-twist metasurfaces.

The geometric phase that introduces the phase discontinuities by the twist of individual meta-atoms has attracted intensive interest in designing multifunctional planar metasurfaces. Typically, the twist axis aligns parallel to the plane of incidence, defined as the plane formed by the norm to the boundary surface and the incident wave vector, termed here as the longitudinal axis. So far, the degree of freedom associated with the other two transverse axes perpendicular to the plane of incidence remains rarely explored.

Metabolomics combined with molecular docking and dynamics simulation to investigate the mechanism of action of Pierre in the treatment of chronic urticaria.

Background: This study investigated the mechanism of action of Pierre (FRP) in the treatment of chronic urticaria (CU) using a rat model and combinatorial analysis of network pharmacology, metabolomics, and molecular dynamics and dynamics simulation data, providing a rationale for its clinical use.

Methods: Twenty-four Sprague-Dawley rats were categorized into control, model, high-dose FRP (40 mg/kg body weight), and low-dose FRP (20 mg/kg body weight) groups. The CU model was induced by ovalbumin.

PAQR5 drives the malignant progression and shapes the immunosuppressive microenvironment of hepatocellular carcinoma by activating the NF-κB signaling.

Background: Progesterone and adipose Q receptor 5 (PAQR5), a membrane receptor characterized by seven transmembrane domains, has been indirectly implicated in pro-carcinogenic activities, though its specific role in hepatocellular carcinoma (HCC) remains to be defined.

Methods: This study aimed to elucidate the molecular mechanisms by which PAQR5 facilitates HCC progression and contributes to the immunosuppressive microenvironment through an integrative approach combining multi-omics analysis and experimental validation. Utilizing data from bulk, single-cell, and spatial transcriptomics cohorts, this study systematically assessed the expression patterns, immune landscape, and functional characteristics of PAQR5 across different levels of resolution in HCC.

A parallel tonotopically arranged thalamocortical circuit for sound processing.

The perception of the sensory world in mammals requires information flow from the thalamus to the cortex. Although the first-order sensory thalamus and its surrounding nuclei are considered the major hub for feedforward thalamocortical transmission, it remains unknown whether any other thalamic input could also contribute to this transmission. We found a thalamic region, the basal region of the ventromedial nucleus of the thalamus (bVM), that sends dense, tonotopically arranged projections to auditory cortex (AuC) fields.

Watt-level multi-gigahertz-repetition-rate femtosecond optical parametric oscillator.

A watt-level multi-gigahertz (GHz) repetition-rate femtosecond optical parametric oscillator (OPO) synchronously pumped by a GHz-repetition-rate Kerr-lens mode-locked Yb:CYA laser is demonstrated in this letter. The output signal had a wavelength tuning range from 1.41 to 1.

FTZ alleviates lipid deposition in diabetic kidney disease by AMPK/ACC/SREBP signaling pathway.

Fufang Zhenzhu Tiaozhi capsule (FTZ) is a patented traditional Chinese medicine preparation that has been used clinically for nearly 10 years to treat hyperglycemia, hyperlipidemia, and other glucolipid metabolic diseases. Previous studies have shown that FTZ can improve diabetic kidney disease (DKD). However, the role and mechanism of FTZ in reducing renal lipid accumulation in DKD remain unclear.

Relevancy Prediction of the Emerging Pathogens with Porcine Diarrhea by Logistic Regression Model.

Porcine viral diarrhea has always been one of the main obstacles to the healthy development of the pig industry in China with its variety of pathogens and complexity of co-infections. Analysis of the dominant mixed-infection model is a fundamental step in boosting the prevention and control of porcine diarrhea. In this study, 3256 porcine fecal samples were collected from 17 pig herds in Shanghai, China, from 2015 to 2023 to identify novel pathogenic infection patterns.

Bioinspired Strong and Tough Layered Bulk Composites via Mycelial Interface Anchoring Strategy.

Lightweight structural composite materials are widely used in automobiles, aerospace, and other fields. However, achieving the integration of structural and functional properties, such as the ability to monitor external forces, remains a significant challenge. Nacre and turtle shells in nature are strong and tough due to their unique ordered structure of alternating soft and hard phases.

Rectal diclofenac versus indomethacin for prevention of post-ERCP pancreatitis (DIPPP): a multicentre, double-blind, randomised, controlled trial.

Background: Recent meta-analyses suggested diclofenac may be superior to indomethacin in preventing post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). The aim of our study was to compare the efficacy of 100 mg rectal indomethacin versus diclofenac on PEP incidences.

Design: This multicentre, double-blinded, randomised controlled trial was conducted in nine tertiary centres in China.

Neuroprotective effects of ethanol extraction from Diels on chronic cerebral hypoperfusion: modulation of the System Xc-/GSH/GPX4 axis to alleviate oxidative stress and ferroptosis.

Introduction: Vascular dementia (VD) is a neurodegenerative disease caused by chronic cerebral hypoperfusion (CCH), which considerably impact patients' quality of life. Ethanol extraction from (RY-A) has gained attention for its potential neuroprotective effects, but its effects and mechanisms of action on CCH are unknown.

Methods: After 30 days of RY-A gavage treatment in a CCH rat model, its effects were evaluated using the Morris water maze test, cerebral blood flow measurements, and HE staining of the brain.

Epileptic Encephalopathy Mutation Displays a Loss-of-Function Phenotype and Distinct Insensitivity to Valproate.

Voltage-gated sodium channels are the main targets of antiepileptic drugs, such as sodium valproate (VPA). Single nucleotide polymorphisms (SNPs) in the Nav1.6 isoform () have been reported to be closely associated with motor dysfunction in pediatric akathisia epileptica.

Excellent Dynamic Non-Wetting Performance Induced by Asymmetric Structure at Low Temperatures: Retraction Actuation and Nucleation Inhibition.

Asymmetric structures have exhibited significant advantages in regulating wetting behavior. Nevertheless, the influence of this unique structural feature on anti-icing performance remains to be further explored. In this work, static/dynamic anti-icing performance is investigated on the asymmetric superhydrophobic structures fabricated by micro-milling combined with electrodeposition.

"Bioactive" Therapeutic Contact Lens Triggered by Biomimetic Chiral Helical Nanoarchitectonics for Rapid Corneal Repair.

Consistent corneal epithelial injury would cause chronic inflammation, neovascularization, and even corneal scarring, resulting in vision loss. Rapid repair is crucial for treatment, within which the use of therapeutic contact lenses presents great promise. A great challenge is how to achieve rapid repair of severely deficient corneal epithelium and regulation of the oxidative stress environment simultaneously.

Real-world experiences with brentuximab vedotion-based regimens in systemic anaplastic large cell lymphoma: a multi-center retrospective study.

Background: Brentuximab vedotin (BV) has demonstrated high remission rates in clinical trials for systemic anaplastic large cell lymphoma (sALCL), yet its real-world effectiveness in China remains unconfirmed. This retrospective observational study evaluates BV-based regimens in patients with sALCL, treated from 2020 to 2023.

Methods: A multi-center observational retrospective study was conducted on patients with sALCL received BV plus cyclophosphamide, doxorubicin, and prednisone (CHP) upfront or BV plus gemcitabine, oxaliplatin(GemOx), gemcitabine, cisplatin, dexamethasone(GDP), or isocyclophosphamide, carboplatin, etoposide (ICE)for later lines.

Mechanism of P-Hydroxy Benzyl Alcohol Against Cerebral Ischemia Based on Metabonomics Analysis.

Stroke is the leading cause of death and disability worldwide, with ischemic stroke accounting for the majority of these. HBA is the active ingredient in and has potential therapeutic effects on central nervous system diseases. In this study, the cell model of cerebral ischemia was replicated by the culture method of oxygen-glucose deprivation/reoxygenation, and the rat model of vascular dementia was established by the two-vessel occlusion method.

An Automatic Deep-Radiomics Framework for Prostate Cancer Diagnosis and Stratification in Patients with Serum Prostate-Specific Antigen of 4.0-10.0 ng/mL: A Multicenter Retrospective Study.

Rationale And Objectives: To develop an automatic deep-radiomics framework that diagnoses and stratifies prostate cancer in patients with prostate-specific antigen (PSA) levels between 4 and 10 ng/mL.

Materials And Methods: A total of 1124 patients with histological results and PSA levels between 4 and 10 ng/mL were enrolled from one public dataset and two local institutions. An nnUNet was trained for prostate masks, and a feature extraction module identified suspicious lesion masks.

Kerr-lens mode-locked GHz-repetition-rate Yb:CYA laser with 11-W average power.

We demonstrate on a high-power 1-GHz Kerr-lens mode-locked (KLM) ytterbium (Yb):CYA laser delivering 149-fs pulses with an average power of 11.1 W. The corresponding single-pulse energy and peak power are 10.