Study on the mechanism of Yajieyixin formula in improving atherosclerosis.

Yajieyixin Formula (YJYXF) is an effective prescription commonly used by Dai medicine practitioners to treat cardiovascular diseases. This study explored how YJYXF helps ApoE mice with atherosclerosis (AS). An atherosclerosis model was established by feeding ApoE mice with a high-fat diet, and treatment with 36.

Horizontal acquisition of the Type I restriction-modification system enhances bacterial pathogenicity by mediating methylation of transcription factor-encoding genes.

The Type I restriction-modification (RM) system, encoded by the hsdR, hsdM, and hsdS genes, plays a crucial role in shaping the prokaryotic DNA methylation landscape. Although known for defending against foreign DNA, key aspects of its evolutionary trajectory and functional implications after stable inheritance remain poorly understood. In this study, we identified four primary types of Type I RM systems across 4273 prokaryotic genomes based on gene arrangement.

Rewiring of cell morphology by Small protein B enhances stress tolerance and colonization in Aeromonas veronii under adverse conditions.

Pathogens often display morphological plasticity to withstand environmental stress and thrive in complex host immune environments. In this study, we demonstrated the morphological adaptation of Aeromonas veronii, a severe pathogen with a wide environmental distribution. Our results establish the critical role of Small protein B (SmpB) in morphological adaptation and reveal a conserved dual-safety regulatory mechanism mediated by ArgR.

hijacks FABP2 to activate quorum-sensing signals and aggravate Crohn's disease by inducing gut dysbiosis.

Background: Crohn's disease (CD) is a chronic inflammatory disorder characterised by intestinal dysbiosis. While inflammation-induced leakage of host proteins is a known phenomenon in CD, how these proteins affect the gut microbiota and contribute to dysbiosis remains unclear. One hypothesis is that commensal bacteria hijack these proteins, exacerbating inflammation in CD.

A smart all-in-one strategy based on hybrid bacteria with targeting drug delivery and spatiotemporal drug release to boost the synergistic therapeutic efficacy against TNBC.

Combining immunotherapy with photodynamic therapy (PDT) can optimize their synergistic therapeutic efficacy against triple-negative breast cancer (TNBC), but the limited accumulation of photosensitizers at the tumor site and the off-target binding of PD-L1 antibody with hematopoietic cells and normal tissues severely reduce the therapeutic efficacy and increase the systemic toxicity, leading to failure in the clinical treatment. Therefore, engineered Rosetta(DE3) expressing PD-L1 nanobody (Rosetta(pPD-L1nb)) are constructed and covalently conjugated with a photosensitizer, chlorin e6 (Ce6), to develop hybrid bacteria (CeRosetta(pPD-L1nb)). As a facultative anaerobe, CeRosetta(pPD-L1nb) can targetedly accumulate and colonize at the hypoxic and hypernutrient microenvironment of tumor, consistently synthesize PD-L1nb and compete for nutrition consumption with tumor cells to inhibit tumor growth.

Danshen (Salvia miltiorrhiza) extract suppresses the growth of melanoma cells and induces autophagy by inhibiting the STAT3 pathway.

Ethnopharmacological Relevance: Danshen (Salvia miltiorrhiza Bunge), a revered traditional Chinese medicine derived from dried roots and rhizomes, has historically been employed to invigorate blood circulation, resolve stasis, and treat cardiovascular disorders. Emerging evidence highlights its ethnopharmacological relevance in cancer therapy, particularly for suppressing tumor progression. While melanoma remains a therapeutic challenge, Danshen's potential mechanisms against this malignancy warrant systematic exploration.

Loganin ameliorates left ventricular fibrosis and dysfunction induced by pressure overload via the Sirt1/AKT/TGF-β1 signaling pathway.

Loganin (LG), a natural compound derived from Cornus officinalis Sieb. et Zucc., possesses diverse pharmacological properties, such as anti-inflammatory, anti-hypertrophic, and antioxidant effects.

Przewaquinone A, as a natural STAT3 inhibitor, suppresses the growth of melanoma cells and induces autophagy.

Background: Melanoma is a deadly malignant skin cancer with common risk factors including prolonged ultraviolet exposure. Understanding the mechanisms of signal transducer and activator of transcription (STAT3) signaling and discovering inhibitors of STAT3 signaling are considered promising melanoma treatments for melanoma. Przewaquinone A (PrA), a lipophilic diterpene quinone isolated from Salvia przewalskii Maxim.

Preparation and Characterization of Low-Molecular-Weight Polyacrylonitrile.

Polyacrylonitrile (PAN) is renowned for its excellent physical and chemical properties, making it a promising candidate for producing high-performance and energetic materials. However, traditional high-molecular-weight PAN suffers from poor solubility and low reactivity, which limits its application as a precursor for advanced materials. To overcome these issues, this study successfully synthesized low-molecular-weight PAN (M: 6.

Characteristics and sex differences in bronchopulmonary dysplasia-related pulmonary hypertension.

Background: Pulmonary hypertension (PH) secondary to bronchopulmonary dysplasia (BPD) is associated with increased mortality. This study aims to elucidate the risk factors for BPD-PH development and the long-term prognostic factors in pediatric BPD.

Methods: We analyzed 1082 BPD patients under the age of three.

A study of the relationship between social support, caregiving experience and depressed mood of family caregivers of home-dwelling older adults with disability- - a cross-sectional study.

Background: Population aging in China has intensified psychological challenges for family caregivers. This study investigates the relationships among social support, caregiving experiences, and depressed mood in family caregivers of home-dwelling older adults with disabilities, aiming to provide theoretical guidance for enhancing caregivers' physical and mental well-being and optimizing home-based care services.

Methods: A random sample of 494 family caregivers from three districts in a specified city was surveyed.

Neuroprotective effects of ethanol extraction from Diels on chronic cerebral hypoperfusion: modulation of the System Xc-/GSH/GPX4 axis to alleviate oxidative stress and ferroptosis.

Introduction: Vascular dementia (VD) is a neurodegenerative disease caused by chronic cerebral hypoperfusion (CCH), which considerably impact patients' quality of life. Ethanol extraction from (RY-A) has gained attention for its potential neuroprotective effects, but its effects and mechanisms of action on CCH are unknown.

Methods: After 30 days of RY-A gavage treatment in a CCH rat model, its effects were evaluated using the Morris water maze test, cerebral blood flow measurements, and HE staining of the brain.

Surface-engineered bio-manufactured gas vesicles for multimodal imaging of glioma.

Integrated imaging techniques offer enhanced medical insights into the central nervous system by combining different modalities. In glioma diagnosis, the challenge often lies in delivering contrast agents effectively across the blood-brain barrier. We present an integrated multimodal imaging biohybrid, GV@pCY5, which enables blood-brain barrier penetrating as well as fluorescence and ultrasound (FL/US) imaging capabilities.

A systematic review of plastic recycling: technology, environmental impact and economic evaluation.

In this systematic review, advancements in plastic recycling technologies, including mechanical, thermolysis, chemical and biological methods, are examined. Comparisons among recycling technologies have identified current research trends, including a focus on pretreatment technologies for waste materials and the development of new organic chemistry or biological techniques that enable recycling with minimal energy consumption. Existing environmental and economic studies are also compared.

Controlled Multi-Dimensional Assembly of Calcium Carbonate Particles with Industrial By-Product Carbide Slag and CO.

The utilization of carbide slag, an industrial by-product, as a resource to prepare value-added products has a profound impact not only for sustainable synthesis and the circular economy but also for CO reduction. Herein, we report the very first example of the controlled multi-dimensional assembly of calcium carbonate particles at the micrometer scale with industrial by-product carbide slag and CO. Calcium carbonate particles of distinctly different sizes, shapes, and morphologies are obtained by finely tuning the assembly conditions.

Adjuvant Effect of in Sublingual Immunotherapy of Asthmatic Mice.

: Sublingual immunotherapy (SLIT) has shown promise in mitigating allergic asthma symptoms; nevertheless, its high dose and prolonged duration of treatment raise safety concerns. This study explored the potential of () to enhance the effectiveness of SLIT in a mouse model of allergic asthma. : Allergic asthma was induced in Balb/c mice following sensitization and challenge with a house dust mite (HDM) allergen.

Solvation enabled highly efficient gradient assembly creates robust metal-phenolic coatings.

Metal-phenolic networks (MPNs) are supramolecular materials that have received interest in various fields, including biomedicine, separations, environmental remediation, and catalysis. Despite recent advances, the construction of thick and robust MPN coatings that withstand harsh conditions (e.g.

[Inhibition of miR-30d-5p promotes mitochondrial autophagy and alleviates high glucose-induced injury in podocytes].

Objectives: To study the role of microRNA (miR)-30d-5p in high glucose-induced podocyte injury.

Methods: Podocytes were hyperglycated with 30 mmol/L glucose, transfected with miR-30d-5p inhibitor and mimic, and then treated with 1 mg/mL 3-methyladenine (3-MA). The transfection efficiency of miR-30d-5p was quantified by reverse transcription PCR.

20(S)-Ginsenoside Rh2 induces apoptosis and autophagy in melanoma cells via suppressing Src/STAT3 signaling.

Background: 20(S)-Ginsenoside Rh2 (GRh2) has been extensively studied for multifaceted health benefits. However, the anti-melanoma effect of GRh2 remains poorly understood. Herein, the anti-melanoma effects and underlying mechanisms of GRh2 were investigated.

Enhancing the Electrocatalytic Oxidation of 5-Hydroxymethylfurfural Through Cascade Structure Tuning for Highly Stable Biomass Upgrading.

Electrocatalytic 5-hydroxymethylfurfural oxidation reaction (HMFOR) provides a promising strategy to convert biomass derivative to high-value-added chemicals. Herein, a cascade strategy is proposed to construct Pd-NiCoO electrocatalyst by Pd loading on Ni-doped CoO and for highly active and stable synergistic HMF oxidation. An elevated current density of 800 mA cm can be achieved at 1.

Dysregulation of lipid metabolism in chronic kidney disease and the role of natural products.

Dysregulation of lipid metabolism plays a key role in the onset and progression of CKD, and a thorough understanding of its regulatory mechanisms is essential for the development of effective treatments. In recent years, an increasing number of studies have focused on the pharmacological activities of natural products and their application in the treatment of chronic diseases. Natural products, including plant extracts and bioactive compounds, have been shown to exert anti-inflammatory, antioxidant, antifibrosis, and anti-apoptotic effects through various signaling pathways in the treatment of CKD.

Polydimethylsiloxane enabled triple-action water-resistant coating with desirable relaxation rate in clear aligner.

Clear aligners undergo rapid stress relaxation in warm, moist oral environments, compromising therapeutic effectiveness and longevity of treatment. To develop an innovative multilayer composite material with improved stability and reduced stress release, we have engineered an innovative coating characterized by the surface aggregation of polydimethylsiloxane (PDMS), which imparts a pronounced hydrophobic effect. In addition, the chemically and physically cross-linked structure of the coating reduces the free volume created by molecular chain rearrangement owing to the presence of water molecules, thereby minimizing water penetration into the coating.

Caffeic acid mitigates myocardial fibrosis and improves heart function in post-myocardial infarction by inhibiting transforming growth factor-β receptor 1 signaling pathways.

Myocardial fibrosis is a pathological, physiological change that results from alterations, such as inflammation and metabolic dysfunction, after myocardial infarction (MI). Excessive fibrosis can cause cardiac dysfunction, ventricular remodeling, and heart failure. Caffeic acid (CA), a natural polyphenolic acid in various foods, has cardioprotective effects.