Hybrid inno-zigzag slab amplifier delivers gain for 1 kHz high-energy picosecond pulses.

We report a novel, to the best of our knowledge, inno-zigzag slab laser amplifier that innovatively combines features of innoslab and zigzag slab amplifiers. Operating at 1 kHz repetition rate, this architecture amplifies 300 ps pulses from 0.4 mJ to 57.

Generation of 431 fs, 321 μJ femtosecond pulses from chirped-pulse Yb-fiber and Yb:YAG hybrid amplifiers by using FBG spectral shaping technique.

A hybrid chirped pulse amplification (CPA) system is demonstrated based on a fiber seed source and a three-stage Yb:YAG crystal amplifier. We investigate the mechanism of gain narrowing in a CPA system through theoretical and experimental research. The gain narrowing can be suppressed by pre-shaping the pulse spectrum via a fiber Bragg grating (FBG) with a specifically designed spectral characteristic before amplification.

1 kHz, 70 mJ, high-energy hundred-picosecond fiber-solid-state hybrid laser amplification.

We have demonstrated a 1 µm fiber-solid-state hybrid high-energy laser in the hundred-picosecond range. Operating at a repetition rate of 1 kHz, the output energy was 71.1 mJ with a pulse duration of 63.

315 mJ, 430 ps, high-energy laser at 1 kHz repetition rate based on a zig-zag slab amplifier.

We have demonstrated a 1 µm high-energy zig-zag slab laser amplifier. Operating at a repetition rate of 1 kHz, the output energy was 315 mJ with a pulse duration of 430 ps. A two-stage end-pumped Nd:YVO laser was used to pre-amplify the seed energy (320 µJ) of the passively Q-switched microchip laser to 6.

Relationship between chromatin configuration and maturation ability of rat oocytes in vitro and in vivo.

Purpose: Embryo engineering requires a large number of oocytes, which undergo in vitro maturation (IVM). Understanding how to select the best quality oocytes is key to improving IVM efficiency. Oocytes have different germinal vesicle (GV) chromatin configurations, which may explain the heterogeneity in oocyte quality during IVM.

LncRNA PWRN2 promotes polycystic ovary syndrome progression via epigenetically reducing ATRX by recruiting LSD1.

Long non-coding RNA has been shown to mediate the progression of polycystic ovary syndrome (PCOS). However, the role and mechanism of Prader-Willi region nonprotein coding RNA 2 (PWRN2) in PCOS progression remain unclear. In our study, Sprague-Dawley rat was injected with dehydroepiandrosterone to mimic PCOS rat models.

Establishment and optimization of an in vitro guinea pig oocyte maturation system.

Guinea pigs are a valuable animal model for studying various diseases, including reproductive diseases. However, techniques for generating embryos via embryo engineering in guinea pigs are limited; for instance, in vitro maturation (IVM) technique is preliminary for guinea pig oocytes. In this study, we aimed to establish and optimize an IVM method for guinea pig oocytes by investigating various factors, such as superovulation induced by different hormones, culture supplementation (e.

Gene therapy for cystic fibrosis: Challenges and prospects.

Cystic fibrosis (CF) is a life-threatening autosomal-recessive disease caused by mutations in a single gene encoding cystic fibrosis transmembrane conductance regulator (CFTR). CF effects multiple organs, and lung disease is the primary cause of mortality. The median age at death from CF is in the early forties.

Follicular development in livestock: Influencing factors and underlying mechanisms.

Livestock farming development has become increasingly important in recent years. It not only provides us with meat nutrition and pet feeding but also increases the economic value by providing numerous employment opportunities, which improves our life quality. The livestock farming development depends on successful animal reproduction.