Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Objectives: This meta-analysis aimed to synthesize current evidence and address inconsistencies in the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on children and adolescents with overweight or obesity. We sought to: (1) assess the effects of HIIT and MICT non-exercise controls; (2) compare HIIT and MICT directly; and (3) identify potential moderators through subgroup analyses.

Methods: Systematic searches were conducted in PubMed, Web of Science, China National Knowledge Infrastructure, and CSTJ. Standardized mean differences (SMD) were calculated using a random-effects model. Subgroup and sensitivity analyses explored potential moderators.

Results: A total of 26 moderate-to-high-quality studies (Randomized controlled trials and non-RCT) involving 1,078 participants (765 males, 313 females; aged 9-19) were included. Compared with controls, HIIT significantly reduced fat mass (SMD = -0.69), waistline (SMD = -0.67), body weight (SMD = -0.81), diastolic blood pressure (diastolic blood pressure, SMD = -0.68), and improved VOmax (SMD = 2.06). moderate-intensity continuous training showed significant effects on BMI (SMD = -1.58), body weight (SMD = -0.59), DBP (SMD = -0.60), and VOmax (SMD = 1.26). HIIT outperformed MICT in improving VOmax (SMD = 0.81) and reducing systolic blood pressure (systolic blood pressure, SMD = -0.51). Subgroup analyses showed that HIIT yielded greater benefits than MICT in improving VOmax among overweight children, reducing SBP in obese male adolescents, and in programs involving more than three sessions per week.

Conclusion: HIIT was more effective than MICT in improving VOmax and reducing SBP, especially in specific subgroups. Running-based HIIT three times per week is recommended, while cycling may offer a safer alternative. Results should be interpreted cautiously due to limited subgroup data and potential bias.

Prospero Registration: CRD42024612098.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12343602PMC
http://dx.doi.org/10.3389/fphys.2025.1625516DOI Listing

Publication Analysis

Top Keywords

blood pressure
16
moderate-intensity continuous
12
continuous training
12
smd
12
vomax smd
12
mict improving
12
improving vomax
12
high-intensity interval
8
interval training
8
children adolescents
8

Similar Publications

Background: Diabetic retinopathy (DR) is the leading cause of preventable blindness. Although hyperglycaemia is the primary driver, other modifiable risk factors may contribute to DR development. This study investigated the association between haemoglobin levels and DR risk in adults with type 2 diabetes.

View Article and Find Full Text PDF

Biomarker-based pre-heart failure screening in a middle-aged rural population.

J Cardiol

September 2025

Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Department of Epidemiology, Disease Control, and Prevention, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan. Electronic address:

Background: Guidelines recommend biomarker-based screening for pre-heart failure (pre-HF) among at-risk populations. Although the asymptomatic nature of pre-HF necessitates proactive screening, real-world implementation remains understudied. This retrospective study analyzed data from a regional pre-HF screening initiative, integrated into annual health screenings, to evaluate: (1) the prevalence of elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels, (2) associated echocardiographic findings, and (3) adherence across the screening-to-consultation pathway.

View Article and Find Full Text PDF

Aims: Acute restraint stress (RS) has been reported to activate the supraoptic nucleus of the hypothalamus (SON). The aim of the present study was to evaluate the role of glutamatergic neurotransmission in the SON on autonomic [mean arterial pressure (MAP), heart rate (HR), and tail cutaneous temperature], neuroendocrine (plasma levels of corticosterone, oxytocin, and vasopressin), and behavioral responses to RS.

Methods: Male Wistar rats with bilateral SON cannulas received microinjections of NMDA or non-NMDA receptor antagonists or vehicle before restraint stress, and the effects on cardiovascular, tail temperature, hormonal, and behavioral responses were evaluated RESULTS: Microinjection of DL-AP7 or NBQX into the SON reduced MAP increases and tail temperature decreases induced by RS.

View Article and Find Full Text PDF

Background: Excessive oxidative stress is well known to participate in the pathogenesis of hypertension. A major regulator of oxidative stress is the transcription factor Nuclear factor erythroid 2-related factor 2 (Nrf2). However, the role of Nrf2 in the pathogenesis of hypertension is not completely understood, especially at the endothelial cell level.

View Article and Find Full Text PDF