Publications by authors named "Li-Chen Chang"
Background: Diabetic retinopathy (DR) is the leading cause of preventable blindness. Although hyperglycaemia is the primary driver, other modifiable risk factors may contribute to DR development. This study investigated the association between haemoglobin levels and DR risk in adults with type 2 diabetes.
View Article and Find Full Text PDFBackground: This study investigated whether preoperative use of sodium-glucose cotransporter 2 inhibitors (SGLT2is), known for their cardio-renal benefits in type 2 diabetes (T2DM), reduces postoperative acute kidney injury (AKI) after metabolic and bariatric surgery (MBS).
Methods: The TriNetX research network was used to analyze propensity-matched patients with T2DM who underwent MBS between 2010 and 2024. We compared patients who received SGLT2is (discontinued ≥ 1 week before surgery) with those using other antidiabetic medications.
Background: Pulmonary atelectasis is a significant complication of metabolic and bariatric surgery (MBS). Sugammadex enables rapid neuromuscular blockade reversal compared to neostigmine, but its impact on atelectasis prevention remains unclear.
Methods: This retrospective multicenter study used the TriNetX database to analyze adult patients who underwent MBS between 2010 and 2024.
Background: Vitamin D deficiency (VDD) has emerged as a potential contributor to diabetic complications. This study aimed to investigate the association between VDD at the time of type 2 diabetes mellitus (T2DM) diagnosis and subsequent risk of developing diabetic retinopathy (DR).
Methods: This retrospective cohort study used data from the TriNetX Research Network to analyze adult patients newly diagnosed with T2DM between January 2020 and December 2022.
Background: Obstructive sleep apnea (OSA) is highly prevalent in patients undergoing metabolic surgery and can complicate recovery. While OSA and COVID-19 share common pathophysiological mechanisms involving systemic inflammation and respiratory dysfunction, their combined impact on surgical outcomes remains poorly understood.
Methods: Using TriNetX data from June 2022 to December 2024, we retrospectively analyzed adult patients with OSA undergoing metabolic surgery.
While the association between COVID-19 and acute kidney injury (AKI) is well documented, the impact of COVID-19 on the development of advanced chronic kidney disease (CKD) remains unclear, particularly in patients without initial AKI. Using the TriNetX healthcare database, we conducted a matched cohort study comparing 141,587 COVID-19 and 141,587 influenza patients. We excluded patients with AKI within one month of infection and matched groups on demographics, comorbidities, and baseline laboratory values.
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- An updated meta-analysis investigated the effects of intravenous iron supplementation on reducing red blood cell (RBC) transfusion risk in adult patients after cardiac surgery, incorporating recent data from 14 randomized controlled trials with a total of 2,043 subjects.
- Results revealed that intravenous iron significantly decreased the likelihood of RBC transfusions (relative risk 0.77) and improved postoperative hemoglobin levels and iron status compared to control groups.
- The findings suggest that integrating intravenous iron supplementation into perioperative care could enhance patient outcomes in blood management without increasing mortality risk.
Article Synopsis
- This meta-analysis investigates how effective a single dose of intravenous steroids is for enhancing postoperative recovery quality in adult surgery patients, using validated QoR scales.
- The study included eleven randomized controlled trials with 951 patients and measured various outcomes, including overall recovery scores and pain management.
- Results show that intravenous steroids significantly improved recovery scores and reduced pain and nausea compared to placebo, suggesting they are beneficial for postoperative care.*
Article Synopsis
- It included seven randomized controlled trials with a total of 622 patients, revealing that magnesium sulfate significantly improved overall recovery scores and specific aspects like pain and physical comfort compared to a placebo
- Additionally, magnesium sulfate also reduced the need for opioids during surgery and lowered instances of postoperative nausea and vomiting, indicating its potential benefits for pain management and patient recovery.