Study on the alteration of gut microbiota in ovariectomized rats and the impact of estrogen intervention over a 3-month period.

Postmenopausal osteoporosis (PMOP) is a common primary osteoporosis. With the aging of the population, it is becoming a major disease that endangers health and quality of life. The purpose of this study was to explore the effect of gut microbiota on PMOP by observing the changes in the levels of estradiol, bone density, and gut microbiota diversity in rats after 3 months of OVX surgery.

Taxifolin and Astilbin Protect Against Cadmium-Induced Oxidative Stress and Apoptosis in Chicken Liver Cells via Nrf2/HO-1 Signaling.

Cadmium (Cd) is a toxic heavy metal pollutant widely present in the environment. It can accumulate in organisms through the food chain and pose a serious health threat to various organisms, including poultry. The liver is one of the main target organs for cadmium toxicity.

Genetic modulation of lncPSMB1 confers non-syndromic cleft lip with or without cleft palate susceptibility by promoting cell apoptosis.

The genetic roles of protein-encoding genes in nonsyndromic cleft lip with or without cleft palate (NSCL/P) susceptibility have been intensively studied, but many gaps remain including the emerging roles of long non-coding RNA. In this study, we found that NSCL/P risk-associated SNPs may have higher chances to modulate lncRNA genes than protein-coding genes. Through a multi-omics screen strategy, we identified a variant in lncPSMB1, associated with the risk of NSCL/P.

Learning Engagement and Professional Identity Among Pre-Service Teachers: The Sequential Mediating Role of Adaptability and Self-Concept.

The fostering of professional identity among pre-service teachers has emerged as a pivotal research focus in contemporary pedagogical studies. Significantly, learning engagement is a core component of pre-service teachers' training during their education stage. A survey involving 632 pre-service teachers from China was conducted.

[Sequential therapy with carglumic acid in three cases of organic acidemia crisis].

Case 1: A 19-day-old male infant presented with poor feeding and decreased activity for 2 weeks, worsening with poor responsiveness for 3 days. At 5 days old, he developed poor feeding and poor responsiveness, was hospitalized, and was found to have elevated blood ammonia and thrombocytopenia. Whole-genome genetic analysis revealed a pathogenic homozygous mutation in the gene, NM-000282.

Microglia-neuron crosstalk in Alzheimer's disease: an exploration of molecular mechanisms and pathological implications.

Microglia, the resident immune sentinels of the central nervous system (CNS), engage in dynamic crosstalk with neurons, the principal units of information transmission, to maintain CNS homeostasis. Emerging research has established that dysregulation of this intricate communication network critically contributes to Alzheimer's disease (AD) pathogenesis, offering novel insights for therapeutic development. In this review, we dissect the molecular mechanisms underlying multifaceted microglia-neuron interactions in AD.

Cladribine and medium-dose cytarabine intensified busulfan plus cyclophosphamide conditioning regimen for adults high-risk B-cell acute lymphoblastic leukemia.

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the most effective salvage strategy for B-cell acute lymphoblastic leukemia (B-ALL). In this study, we explored the efficacy and safety of cladribine and medium-dose cytarabine intensified busulfan plus cyclophosphamide conditioning regimen (CBAC) for high-risk B-ALL patients at complete remission (CR) after chemotherapy undergoing allo-HSCT. And compared it with patients historical received traditional total body irradiation plus cyclophosphamide (TBI-Cy) regimen.

Shikimic acid derived carbon-dots nanozyme with peroxidase-like activity: A dual-mode probe for ratiometric fluorescence and colorimetric detection of hymexazol.

Hymexazol is extensively used as a pesticide in agriculture and may pose potential hazards to human health as well as the environment. However, fluorescent or colorimetric detection of hymexazol is rarely reported. In this study, a fluorescence carbon-dots nanozyme (Fe-SACDs-RhB) with peroxidase-like activity was derived from shikimic acid.

Advancing Therapeutic Strategies in Atopic Dermatitis: Emerging Targets and Personalized Approaches.

Atopic dermatitis (AD) is a chronic inflammatory skin disorder marked by intricate interplay among skin barrier dysfunction, immune dysregulation, and microbial dysbiosis. While therapeutic advancements targeting T helper 2 (Th2) cytokines, such as interleukin (IL)-4 and IL-13, and the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway have yielded promising outcomes, a significant proportion of patients still experience inadequate relief, particularly from persistent pruritus. Achieving minimal disease activity remains an unmet clinical priority and a cornerstone of effective AD management.

Biotoxicity of thorium at environmental concentrations: Multi-omics reveal developmental and hepatic toxicity in zebrafish.

Thorium (Th) is an important strategic resource with a wide range of applications in both civil and nuclear industries. However, intensive rare earth mining has elevated Th concentrations in natural water bodies, posing significant environmental and health risks. Based on previous reports, this study evaluated the biotoxicity of Th(IV) at concentrations of 0.

Promoting retinal ganglion cell regeneration with targeted liposome-based delivery of MHY1485 for optic nerve repair.

Optic neuropathy, characterized by the irreversible degeneration of RGCs, leads to vision loss for which treatment options remained limited. Nanoparticle-based therapeutic strategies have been developed to stimulate RGCs regeneration; however, insufficient nanoparticles delivery to RGCs and a lack of robust stimulation of RGCs intrinsic regenerative capacity, have limited their application. Here, we demonstrate that a RGC-targeting Tet1 conjugated to liposome delivery system (Lipo-T) enhances therapeutic agent delivery to RGCs while minimizing off-target effect for activating glial cells.

Nanostructured conductive polymers: synthesis and application in biomedicine.

Conductive polymers (CPs), distinguished by their sp-hybridized carbon backbone, offer remarkable electrical conductivity while maintaining the advantageous mechanical flexibility and processing characteristics typical of organic polymers. Compared to their bulk counterparts, nanostructured CPs exhibit unique physicochemical properties, such as large surface areas and shortened charge/mass transport pathways, making them promising candidates for various applications. This mini review explores various synthesis methodologies for nanostructured CPs, including electrospinning, hard templating, and soft templating techniques, while elucidating their advantages and disadvantages.

Tandem Synergistic Catalysis on Cu-Pd/BiTiO Nanorods Promoting Highly Selective Photoconversion of CO to Ethyl Alcohol.

The production of high-energy-density liquid fuels through the photoconversion of CO offers a highly efficient method for storing sustainable solar energy for future use. BiTiO (BTO) nanorods loaded with Cu-Pd nanoalloys were designed for the highly selective photoreduction of CO to ethyl alcohol, using HO as the proton source. A tandem synergistic catalysis mechanism was proposed for this CO photoconversion process.

Disentangling Organ-Specific Roles of Farnesoid X Receptor in Bile Acid and Glucolipid Metabolism.

Background And Aims: The farnesoid X receptor (FXR) is an attractive pharmaceutical target for metabolic dysfunction-associated steatotic liver disease (MASLD). However, its tissue-specific roles in energy metabolism remain controversial, hindering the development of effective therapies. To address this, new approaches are required.

The Aberrantly Expressed Nuclear Factor (Erythroid-derived 2)-Like 2 Participates in aGVHD by Modulating the Activation and Differentiation of CD4 + T Lymphocytes.

Background: Current investigation indicates that nuclear factor (erythroid-derived 2)-like 2 (NRF2) possesses both proinflammatory and anti-inflammatory capabilities in T cells, yet its exact function in acute graft-versus-host disease (aGVHD) CD4 + T cells remains unexplored.

Methods: This study aims to determine NRF2 levels within CD4 + T cells of patients with or without aGVHD and analyze the correlation between T-cell receptor activation and NRF2 expression. RNA sequencing was used to detect changes in the expression profile of CD4 + T cells after overexpression of NRF2, and functional enrichment analysis was performed on the sequencing results.

Cadmium exposure induced spleen inflammation by activating the MAPK/NF-κB/ NLRP3 signaling pathway and the intervention effect of astilbin.

Cadmium (Cd) is an environmental pollutant with strong immunotoxicity effects. Despite this, the mechanisms by which Cd causes spleen damage in chickens are not well understood. Astilbin (ASB) is a dihydroflavone glycoside with anti-inflammatory and anti-oxidation properties.

Yolk and Casein Sequence Self-Assembly for Low-Oil Emulsion Gel and Its Application in Low-Fat Mayonnaise.

High dietary fat food such as mayonnaise (70-80% oil content) can induce obesity and cardiovascular diseases, thus reducing their oil content is required. However, the development of low-fat mayonnaise is still a big challenge since reducing oil content will increase the fluidity, induce phase separation and decrease the stability of mayonnaise. Herein, we provide a novel strategy for developing yolk-casein-based low-fat mayonnaise (30% oil content) with a similar texture to commercial high-fat mayonnaise through post-acidification.

Integrative metabolomics and transcriptomics profiling reveals differential expression of flavonoid synthesis in Ophiopogon japonicus (L. f.) Ker-Gawl. in adaptation to drought.

Drought is one of the consequences of climate change that severely affects plant growth and development. Ophiopogon japonicus (L. f.

Single-Atom Suture.

In atomically thin two-dimensional (2D) materials, grain boundaries (GBs) are ubiquitous, displaying a profound effect on the electronic structure of the host lattice. The random configuration of atoms within GBs introduces an arbitrary and unpredictable local electronic environment, which may hazard electron transport. Herein, by utilizing the Pt single-atom chains with an ultimate one-dimensional (1D) feature (width of a single atom and length up to tens of nanometers), we realized the suture of the electron pathway at GBs of diversified transition metal dichalcogenides (TMDCs).

Identification of CSPG4 as a Biomarker and Therapeutic Target for Infantile Post-Hemorrhagic Hydrocephalus via Multi-Omics Analysis.

Intraventricular hemorrhage in preterm neonates has become a major global health problem and is associated with a high risk of post-hemorrhagic hydrocephalus (PHH). Identifying diagnostic markers and therapeutic targets is a focal challenge in the PHH prevention and control. Here, this study applies multi-omics analyses to characterize the biochemical, proteomic, and metabolomic profiles of the cerebrospinal fluid (CSF) in clinical human cohorts to investigate disease development and recovery processes occurring due to PHH.

The mechanism of tea tree oil regulating the damage of hydrogen sulfide to spleen and intestine of chicken.

Intensification of poultry industry has led to a surge in animal product output, but this has also revealed issues with environmental management in poultry houses, particularly the harmful effects of high hydrogen sulfide (HS) levels on poultry health. The study aimed to assess the therapeutic impact of tea tree oil (TTO) on HS-induced spleen and intestinal injuries in chickens. A total of 240 one-day-old Lohmann Brown chicks were randomly divided into three groups: the control group (CON), the HS exposure group (AVG), and the TTO treatment group (TTG), with four replicates, each consisting of 20 chicks.

The performance of ChatGPT in day surgery and pre-anesthesia risk assessment: a case-control study of 150 simulated patient presentations.

Background: Day surgery has developed rapidly in China in recent years, although it still faces a shortage of anesthesiologists to handle pre-anesthesia routine before surgery. We hypothesized that ChatGPT may assist anesthesia practitioners in preoperative assessment and answer questions on the concerns of patients. The aims of this study were to examine the ability of ChatGPT to assess preoperative risk and determine its accuracy in answering questions regarding knowledge and management of day surgery anesthesia.

Contribution of cervical incompetence to occurrence of second trimester abortion in patients with polycystic ovary syndrome during the frozen embryo transfer cycle.

Background: Second-trimester abortion is a critical issue in infertile women with polycystic ovary syndrome (PCOS) treated with assisted reproductive technology (ART), cervical incompetence (CI) may play a role. Although previous studies have revealed an association between PCOS and CI in women undergoing ART with fresh embryo transfer, the associated risk factors in frozen embryo transfer cycles are still unknown. The primary objective of this study is to examine the impact of CI on the occurrence of second-trimester abortion in women with PCOS undergoing frozen embryo transfer.