Wearable Point-of-Care Biosensor for Biomolecular Assay in Health Monitoring.

Wearable biosensors represent a significant advancement in preventive health monitoring by enabling early disease detection through real-time bioanalysis. This review examines the evolution of point-of-care testing (POCT), with a focus on materials, fabrication techniques, and real-world applications. These biosensors utilize advanced materials, such as supramolecular hydrogels, and innovative manufacturing methods, providing high sensitivity, specificity, and portability.

Clinical Outcomes and Measures for Vaginal Relaxation Syndrome: A Systematic Review.

Objectives: This study systematically investigates the application of clinical outcomes and measures reported in the management of Vaginal Relaxation Syndrome (VRS). It further analyzes and compares variations in clinical outcomes and measures across different interventions in VRS, with a focus on assessing their generalizability and applicability. The findings aim to inform the design of high-quality clinical trials and provide a foundation for developing a Core Outcome Set (COS) and a Core Outcome Measurement Set (COMS).

Effectiveness of self-management intervention program based on Self-Determination Theory and Solution-Focused Approach in adolescents with inflammatory bowel disease: study protocol for a randomized controlled trial.

Background: The incidence of inflammatory bowel disease (IBD) in China has been continuously increasing, with adolescents constituting the peak age group for onset. Effective self-management behaviors are critical for achieving disease remission and facilitating the transition of adolescents with IBD from childhood to adulthood. However, unmet basic psychological needs frequently erode motivation for self-management, resulting in suboptimal self-care practices.

Xiaoyaosan improves depression-like behaviours in mice with post-stroke depression by modulating gut microbiota and microbial metabolism and regulating P2X7R/NLRP3 inflammasome.

Background: Post-stroke depression (PSD) represents the most prevalent complication of stroke and has been reported to be associated with an imbalance in the gut microbiota. Clinically, Xiaoyaosan (XYS) alleviates depressive symptoms in patients with PSD. However, the existing literature does not provide sufficient evidence to ascertain whether XYS can alleviate these symptoms by modulating gut microbiota.

Association between Vessels Encapsulating Tumor Clusters and Circulating Tumor Cells in Hepatocellular Carcinoma: Clinical Evidence and Risk Model Development.

Vessels encapsulating tumor clusters (VETC) and circulating tumor cells (CTCs) are recognized as emerging potential biomarkers in hepatocellular carcinoma (HCC), yet the underlying connection between them is not fully elucidated. This study aims to investigate the association between VETC and CTCs and evaluate their potential clinical utility. This retrospective cohort study (NCT05297955) included 165 HCC patients who underwent curative hepatic resection.

Microglial BDNF modulates arketamine's antidepressant-like effects through cortico-accumbal pathways.

Arketamine, the ()-enantiomer of ()-ketamine, shows even greater rapid and sustained antidepressant-like effects in rodent models compared to esketamine, yet the underlying mechanisms remain unclear. In this study, we used the chronic social defeat stress (CSDS) model to investigate how arketamine exerts its antidepressant-like effects. We found that activating cAMP response element-binding protein (CREB) at S133 and methyl-CpG-binding protein 2 (MeCP2) at S421 drives the transcription of brain-derived neurotrophic factor (BDNF), contributing to arketamine's antidepressant-like effects.

Component Analysis of Saxifraga stolonifera Extract and Its Mechanism of Melanin Inhibition.

Emerging focus on cosmetic safety has propelled exploration of plant-derived whitening agents. Saxifraga stolonifera, a traditional Chinese herb, was investigated for its whitening potential through its ethanol extract (S. stolonifera extract [SSE]).

Comparative Analysis of Nano-Bactericides and Thiodiazole-Copper on Tomato Rhizosphere Microbiome.

Vegetable crops such as tomato are highly susceptible to various pathogens. Nanoparticles (NPs) are emerging as effective nano-bactericides for managing plant pathogens. Communities of rhizosphere bacteria are essential for plant physiological health and also serve as a critical factor in evaluating the environmental compatibility of NPs.

Toxicity of nanoplastics: machine learning combined with meta-analysis.

Nanoplastics (NPs) are widespread in ecosystems, and their biohazards are of increasing concern. The hazards posed by NPs to aquatic and terrestrial plants as well as to aquatic animals have been extensively studied; however, their impact on mammals remains underexplored. Herein, we performed a meta-analysis to quantify the extent of the effects of NPs on mice and developed two machine learning methods to predict the correlations of the detrimental effects of NPs.

The impact of resection margin width on surgical outcomes for solitary hepatocellular carcinoma with sub-classification of microvascular invasion.

Background: The impact of resection margin width on surgical outcomes in hepatocellular carcinoma (HCC) patients with microvascular invasion (MVI) remains controversial. This study explores whether MVI sub-classification influences prognosis after curative resection for solitary HCC.

Methods: We analyzed 601 solitary HCC patients who underwent hepatectomy between May 2018 and December 2019, classifying them into no vascular invasion (NVI), microvessel invasion (MI), and microscopic portal vein invasion (MPVI) groups.

Glycoluril Polymers for Codelivery in Solid Tumor Therapy.

Multicomponent chemotherapy has increasingly become a strategy of great importance in clinical nonsmall cell lung cancer treatments. However, this type of combination chemotherapy has not led to synergistic drug activities. Herein, we present the codelivery of doxorubicin and oxaliplatin via supramolecular nanocapsules.

The Influence of Age on the Effective Dosage of Intravenous Remimazolam for the Relief of Preoperative Anxiety in Pediatric Patients at Median and 95% Effective Doses: A Prospective Study.

Purpose: Preoperative anxiety is an urgent problem in pediatric patients. This trial evaluated intravenous remimazolam for preoperative sedation in pediatric patients, assessing efficacy, safety, and age-dependent dose effects.

Patients And Methods: In this two-part study, Aged 1~6 years old, 293 ASA I-II children [Parental Separation Anxiety Score (PSAS) ≥3 after nonpharmacological interventions] were enrolled.

Investigating the mechanism of Gentiopicroside in rheumatoid arthritis through network pharmacology, molecular docking, and experimental validation.

Rheumatoid arthritis (RA) constitutes a chronic, progressive autoimmune disease, and effective treatment of RA remains a challenge. Due to the multiple side effects and "therapeutic ceiling" effect of current RA medications, it is essential to find natural alternatives and explore their mechanisms of action in RA. In this study, we analyzed the targets of action and signaling pathways of gentiopicroside (GEN) in RA using network pharmacology and validated them through molecular docking and experimental approaches.

Comparison of the Dural Puncture Epidural and Conventional Epidural Analgesia Maintained Using Programmed Epidural Boluses for Labor Analgesia.

Purpose: Research indicates that the dural puncture epidural (DPE) technique offers quicker analgesia onset compared to the conventional epidural (EP) technique. Programmed intermittent epidural bolus (PIEB) is superior to continuous epidural infusion (CEI) for maintaining labor analgesia, providing better pain relief and less motor block. Few studies have explored if combining DPE with the PIEB offers additional benefits in analgesia onset, maintenance, local anesthetic consumption, and side effects compared to DPE with EP.

Controlling the Polarization and Vortex Charge of γ Photons via Nonlinear Compton Scattering.

High-energy vortex γ photons have significant applications in many fields. However, their generation and angular momentum manipulation are still great challenges. Here, we first investigated the generation of vortex γ photons with controllable spin and orbital angular momenta via nonlinear Compton scattering of two-color counter-rotating circularly polarized (CP) laser fields.

Identification of DNA damage and repair gene-related markers in pancreatic ductal adenocarcinoma by single-cell and bulk RNA sequencing.

Background: The DNA damage response (DDR) has a major impact on the development and progression of pancreatic ductal adenocarcinoma (PDAC). Investigating biomarkers linked to the DDR may facilitate prognostic assessment and prediction of immunological characteristics for patients with PDAC.

Methods: The single-cell RNA sequencing (scRNA-seq) dataset GSE212966 was obtained from the GEO database, whereas the bulk RNA-seq data were sourced from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases.

Stromal Stiffness-Regulated IGF2BP2 in Pancreatic Cancer Drives Immune Evasion via Sphingomyelin Metabolism.

Background & Aims: Immunotherapy has shown promising results in cancer treatment; however, it remains largely ineffective for pancreatic ductal adenocarcinoma (PDAC). N6-methyladenosine (m6A), known for its crucial role in cancer biology, is not yet fully understood regarding immune evasion. This study aims to elucidate the associations and mechanisms linking m6A modification with immune evasion in PDAC and propose strategies for clinical intervention.

Evaluation of the measurement properties of premonitory urge patient-reported outcome measure: A systematic literature review.

Objective: This study aims to systematically evaluate the measurement properties of premonitory urge patient-reported outcome measures (PROMs) in patients with tic disorder using Consensus-based standards for the selection of health measurement instruments (COSMIN) methodology and provide recommendations for clinical assessment.

Method: A systematic search was conducted in PubMed, EMBASE, Web of Science, and PsycINFO, from database inception to October 9, 2022, with an additional supplementary search conducted from October 9, 2022, to January 4, 2025. After literature screening and data extraction, two independent reviewers objectively assessed the measurement properties according to COSMIN.

Protective effects of Rosa roxburghii Tratt. extract against UVB-induced inflammaging through inhibiting the IL-17 pathway.

Chronic inflammation is a critical mechanism contributing to the aging process; however, research specifically addressing chronic inflammation in skin biology remains limited. This study investigates the protective mechanism of Rosa roxburghii Tratt. (RRT) extract against UVB-induced inflammaging.

Combining pelvic floor ultrasonography with deep learning to diagnose anterior compartment organ prolapse.

Background: Anterior compartment prolapse is a common pelvic organ prolapse (POP), which occurs frequently among middle-aged and elderly women and can cause urinary incontinence, perineal pain and swelling, and seriously affect their physical and mental health. At present, pelvic floor ultrasound is the primary examination method, but it is not carried out by many primary medical institutions due to the significant shortcomings of training in the early stage and the variable image quality. There has been great progress in the application of deep learning (DL) in image-based diagnosis in various clinical contexts.

The association between perceived social support and self-management behaviors in adolescents and young adults with inflammatory bowel disease: the chain mediating role of basic psychological needs and anxiety/depression.

Introduction: The incidence of inflammatory bowel disease (IBD) has been increasing, with adolescents and young adults being the peak age of onset. Self-management behaviors were demonstrated to enhance remission and quality of life, yet the mechanisms influencing self-management behaviors remained under-explored. Perceived social support is crucial to self-management behaviors, alongside the roles of basic psychological needs, anxiety, and depression.

Targeting pancreatic cancer glutamine dependency confers vulnerability to GPX4-dependent ferroptosis.

Pancreatic ductal adenocarcinoma (PDAC) relies heavily on glutamine (Gln) utilization to meet its metabolic and biosynthetic needs. How epigenetic regulators contribute to the metabolic flexibility and PDAC's response and adaptation to Gln scarcity in the tumor milieu remains largely unknown. Here, we elucidate that prolonged Gln restriction or treatment with the Gln antagonist, 6-diazo-5-oxo-L-norleucine (DON), leads to growth inhibition and ferroptosis program activation in PDAC.

Supramolecular Combination Chemotherapy: Directly Inducing Immunogenic Cell Death To Inhibit Tumor Metastasis via Host-Guest Interactions.

Tumor metastasis is a difficult clinical problem to solve due to tumor heterogeneity and the emergence of antiapoptotic clones driven by tumor evolution. Clinical combination chemotherapy remains a standard treatment for solid metastasis tumors but with worse treatment efficiency. It is worth exploring a high-efficiency and low-side-effect therapeutic method to solve solid metastases.

Type I congenital vaginal atresia with multiple organ malformations.

Background: Vaginal atresia (VA) is a rare female genital tract malformation characterized by the absence or incomplete development of the vagina, often leading to cyclic abdominal pain and menstrual blood retention in adolescent patients. Vaginal atresia is often accompanied by multiple organ malformations. The condition poses significant challenges in diagnosis and management, requiring a multidisciplinary approach.