Study on the ambulatory blood pressure phenotype and its correlation with hemoglobin concentration in untreated hypertensive individuals permanently living in plateau areas.

Ambulatory blood pressure monitoring (ABPM) studies for high altitude (HA) hypertensive patients are limited. We aimed to explore the hypertension phenotypes, and investigate their associations with hemoglobin in untreated hypertensives permanently living in HA. A total of 342 untreated hypertensive patients were included.

Insulin resistance in school-age children: comparison surrogate diagnostic markers.

Background: This study aimed to identify surrogate markers suitable for evaluating insulin resistance in children and adolescents with overweight and obesity.

Methods: Forty-nine reported surrogate markers of insulin resistance were selected, including 14 insulin-based markers and 35 non-insulin-based markers. The markers were analyzed in 800 children aged 7-12 years.

Expression of homeobox B13 gene and metabolomics study in placental tissues of gestational diabetes mellitus.

Our study aimed to investigate the expression characteristics of the homeobox B13 (HOXB13) gene in placental tissues of gestational diabetes mellitus (GDM) and its impact on placental metabolic function. Placental tissues from 30 GDM patients and normal pregnancy cases were collected. The expression of HOX family genes (including HOXB13 and HOXA2 among seven genes) was screened using quantitative polymerase chain reaction, and the protein expression of HOXB13 was validated by Western blot and immunohistochemistry.

Bimetallic-Doped Metal-Organic Gel for Efficient Electrochemiluminescence: Staircase-Mediated Energy Transfer and Applications in Epinephrine Detection.

This study presents the development of a novel bimetallic-doped metal-organic gel (Tb-Eu-MOG) synthesized by codoping terbium (Tb(III)) and europium (Eu(III)) with the Hcptpy ligand and explores its application in electrochemiluminescence (ECL) for sensitive detection of epinephrine (EP). The Tb-Eu-MOG exhibits unique petal nanoflower-like morphology and remarkable ECL signals, attributed to the dual sensitization effects of Tb(III) and Eu(III) on the Hcptpy ligand. The Tb(III) doping facilitates energy transfer and enhances ECL efficiency through a staircase effect.

Influence of anchoring group on charge transport across self-assembled monolayer-based molecular tunnel junctions.

Predicting the charge transport rate, mechanism and dielectric response of solid-state molecular electronics is challenging since these properties depend on many variables such as molecular backbone, electrode material, junction contact geometry, anchoring and terminal functional groups, and so on. Although the effects of the anchoring group (X) on the conductance of single-molecule junctions have been widely investigated, in large-area junctions examples are rare, although the latter makes it possible to also explore the role of dielectric properties on charge transport rates. Here we report a change of 2.

Autologous Tumor-Infiltrating Lymphocyte Infusion plus Anti-Programmed Cell Death Protein 1 Therapy to Cure Advanced Hepatocellular Carcinoma following Palliative Hepatectomy.

Introduction: Adoptive cell therapy derived from autologous tumor-infiltrating lymphocytes (TILs) has demonstrated promising therapeutic efficacy in several cancers. However, its possible synergistic effects with anti-PD-1 therapy in advanced hepatocellular carcinoma (aHCC) remain unexplored. This study aimed to investigate the efficacy of TIL infusion combined with anti-PD-1 therapy for aHCC.

Indicator-Free Detection of Hyaluronidase Based on a Conductivity-Regulated Bipolar Electrochemiluminescence Platform.

Hyaluronidase (HAase) detection plays a critical role in cancer diagnosis and treatment. Most HAase biosensors require the incorporation of exogenous indicators into the sensing reaction for signal transduction, which might involve complex synthesis and modification procedures or potentially interfere with enzymatic activity. Herein, based on the fact that the electrochemiluminescence (ECL) can be regulated via a bipolar electrode (BPE) through the alteration of conductivity in the enzymatic reaction solution, we develop an indicator-free HAase biosensor based on the bipolar-based ECL (BP-ECL) platform.

Refining Prognosis and Treatment Strategies Beyond the Barcelona Clinic Liver Cancer Stage in Hepatocellular Carcinoma with Lung Metastases: A Multicenter Cohort Study.

Lung metastasis is the most common site of extrahepatic spread in hepatocellular carcinoma (HCC) and is associated with significantly poorer outcomes. Current guidelines classify these patients as Barcelona Clinic Liver Cancer (BCLC) stage C, recommending systemic therapy alone. However, this one-size-fits-all approach may overlook potential benefits in selected patients.

ISG15 deficiency in hepatic stellate cells promotes TGFβ2-induced liver fibrosis by counteracting CREB1 ISGylation.

Background: Interferon (IFN)-stimulated gene 15 (ISG15) is a downstream molecule of the IFN pathways central to many cellular processes. ISG15 mainly exerts its function through a post-translational modification process known as ISGylation.

Objective: In this study, the role of ISG15 in the activation of hepatic stellate cells (HSCs) and liver fibrosis was examined.

Effect of Cu Content on Corrosion Resistance of 3.5%Ni Weathering Steel in Marine Atmosphere of South China Sea.

The influence of the copper (Cu) content on the corrosion resistance of 3.5%Ni low-carbon weathering steel was investigated using periodic dry-wet cycle accelerated corrosion tests. The mechanical properties of the steels were assessed via tensile and low-temperature impact tests, while corrosion resistance was evaluated based on weight loss measurements.

Synchronous hepatectomy and splenectomy for patients with BCLC stage 0/A hepatocellular carcinoma and clinically significant portal hypertension: A multicenter retrospective cohort study.

Background: Liver transplantation is restricted by high costs and donor shortages, necessitating exploration of alternative treatments for hepatocellular carcinoma (HCC) with significant portal hypertension (CSPH). This study examined whether synchronous hepatectomy and splenectomy (HS) improves survival over hepatectomy (H) in patients with BCLC stage 0/A HCC and CSPH.

Methods: A total of 525 patients with BCLC stage 0/A HCC and CSPH from 12 centers were under review.

LOXHD1 and RHOB Expression by Monocytes Predicts Progressive Systemic Sclerosis associated Interstitial Lung Disease.

Objective: A leading cause of death among scleroderma (SSc) patients, interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool. We aimed to identify genes signatures that would predict progressive ILD.

Exon Skipping of Ste20-Like Kinase Enhances Glycolysis and Tumor Progression by Activating Enolase 1-Mediated Phosphoenolpyruvate Production.

RNA splicing is frequently dysregulated in tumors. Aberrant RNA splicing can alter tumor metabolism, highlighting the need to elucidate the alternative splicing events that shape the metabolic landscape. In this study, we identified exon skipping in Ste20-like kinase (SLK) that results in a variant isoform (SLKv), which promotes glycolysis in tumor cells.

Targeting Aurora kinase B regulates cholesterol metabolism and enhances chemoimmunotherapy in cholangiocarcinoma.

Background: Cholangiocarcinoma (CCA) is a highly lethal malignant tumour with increasing incidence. Current therapies exhibit limited benefits, which urgently demand the identification of novel therapeutic targets.

Objective: We aimed to identify potential therapeutic targets for CCA and broaden current therapies.

Association between visceral fat area and heart rate variability in high altitude migrants with OSA: the mediating effect of insulin resistance.

Objective: This study was conducted to investigate the association between visceral fat area (VFA) and heart rate variability (HRV) in high-altitude migrants with obstructive sleep apnea (OSA).

Method: We conducted a cross-sectional study comprising 152 OSA participants from 2022 to 2024. We employed multivariable linear regression to further elucidate the association between VFA and HRV.

NEK7-induced phosphorylation of EGFR on serine 1070 drives the acquired lenvatinib resistance in hepatocellular carcinoma.

Background And Aims: Lenvatinib is recognized as a first-line therapy for inoperable hepatocellular carcinoma (HCC) patients. Growing evidence indicates that lenvatinib resistance can be acquired in HCC cells via kinase rewiring.

Approach And Results: We established acquired lenvatinib-resistant organoids and HCC cell lines.

eIF4A controls translation of estrogen receptor alpha and is a therapeutic target in advanced breast cancer.

Most breast cancers depend on hormone-stimulated estrogen receptor alpha (ER) activity and are sensitive to ER inhibition. Resistance can arise from activating mutations in the gene encoding ER () or from reactivation of downstream targets. Newer ER antagonists occasionally show efficacy but are largely ineffective as single agents in the long term.

The role of probiotics in adolescents' obesity.

The prevalence of adolescent obesity continues to rise globally, posing significant public health challenges by affecting both physical and psychological wellness and increasing the risk of metabolic diseases in adulthood. Probiotics may influence obesity through various mechanisms, including restoring gut microbiota balance, reducing chronic inflammation, modulating lipid metabolism, aiding in weight control, and improving metabolic health. This review aims to explore the mechanisms by which probiotics act as key modulators of obesity and summarize current findings from clinical trials involving probiotics in adolescent obesity.

New evidence for the effect of type 2 diabetes and glycemic traits on lung function: a Mendelian randomization and mediation analysis.

Background: Type 2 Diabetes Mellitus (T2DM) is common worldwide. Patients with T2DM often experience reduced lung function, but the relationship between the two conditions remains uncertain. This study employed Mendelian Randomization (MR) to explore the causal link between T2DM and lung function, and to identify the factors that mediate this relationship.

Bioinspired Dual-Ionic-Site Single-Atom Nanozymes for Synergistic Ferroptosis/Cuproptosis and Enhanced Immune Checkpoint Blockade Therapy.

Clinical cancer patients often exhibit limited responses to immunotherapy, primarily due to the low immunogenicity of solid tumors and insufficient T cell infiltration, which reduce the effectiveness of immune checkpoint blockade (ICB) therapy. To address this challenge, a Fe/Cu dual-ionic-site single-atom nanozyme (dis-SAzyme) is constructed with multiple catalytic active sites, which can catalyze ROS generation and deplete antioxidants, thereby inducing synergistic ferroptosis and cuproptosis to enhance immunogenicity. Camouflaging doxorubicin-loaded dis-SAzyme with a bioinspired cancer cell membrane (dis-SAzyme-Dox@M) enables targeted navigation to the tumor region, leading to selective ferroptosis/cuproptosis in cancer cells.

Association between Vessels Encapsulating Tumor Clusters and Circulating Tumor Cells in Hepatocellular Carcinoma: Clinical Evidence and Risk Model Development.

Vessels encapsulating tumor clusters (VETC) and circulating tumor cells (CTCs) are recognized as emerging potential biomarkers in hepatocellular carcinoma (HCC), yet the underlying connection between them is not fully elucidated. This study aims to investigate the association between VETC and CTCs and evaluate their potential clinical utility. This retrospective cohort study (NCT05297955) included 165 HCC patients who underwent curative hepatic resection.

Sleep indicators and staging: A functional near-infrared spectroscopy study in healthy young adults.

Functional near-infrared spectroscopy(fNIRS)-based sleep staging has attracted considerable interest due to its portability and limited interference with sleep. However, few studies have systematically examined sleep indicators or formulated sleep staging models based on fNIRS features labelled by polysomnography(PSG). This study aimed to address these shortcomings and promote the application of fNIRS in sleep monitoring.

Morning vs Bedtime Dosing and Nocturnal Blood Pressure Reduction in Patients With Hypertension: The OMAN Randomized Clinical Trial.

Importance: Nocturnal blood pressure is difficult to manage in clinical practice. Antihypertensive chronotherapy may offer a potential approach for better control. However, the clinical evidence supporting this approach remains controversial.