Autogenous Transplantation of an Immature Undersized Third Molar to Rehabilitate a Cyst-Associated Lateral Incisor Defect: A 3-Year Case Report.

Severe periapical cysts frequently result in tooth loss with concomitant severe alveolar bone destruction, precluding immediate implant placement. Autogenous tooth transplantation (ATT), which involves transplanting the patient's own tooth to the recipient site, offers a biological approach to reconstruct both the dentition and supporting bone structures. This report presents a 25-year-old female with a mobile, discolored maxillary right lateral incisor (#12) exhibiting grade 3 mobility due to a large periapical cyst (extending to #14 on CBCT) with root developmental arrest, secondary to Oehlers type II dens invaginatus.

Cell-Based Assays to Study SUMOylation in Drosophila.

SUMOylation (Small Ubiquitin-like Modifiers, SUMO group) is known to regulate protein-protein interactions, subcellular localization, and the activities of SUMO-modified targets. Over the past two decades, the SUMO pathway has been implicated in numerous developmental processes in Drosophila, including embryogenesis, wing morphogenesis, innate immune system development, neurogenesis, and apoptosis. Notably, the Hedgehog (Hh) family of secreted proteins activates the Ser/Thr kinase Fused (Fu) by promoting its SUMOylation, which is crucial for Drosophila development.

Advances in the Study of Pyroptosis in Dermatological Disorders.

Pyroptosis is a proinflammatory procedural cell die-off characterised by the forming of membrane pores that are mediated by a series of aerogelin proteins. Pyroptosis occurs by caspase-1 dependent typical signalling pathways, caspase-4/5/11 dependent atypical signalling pathways, and other signalling pathways (GSDME, GSDMD, GSDMA, GSDMB and GSDMC mediated signalling pathways). Pyroptosis may assist in the elimination of the pathogen as a type of mechanism of host defence, but pyroptosis-induced inflammation can lead to dysfunction and organ damage, exacerbating the pathology of the disease.

Safety and effectiveness of iron sucrose therapy in paediatric patients with iron deficiency anaemia: a single-institution retrospective study.

Background: Iron deficiency anaemia (IDA) is the most prevalent nutritional deficiency among children globally. Intravenous (IV) iron serves as an alternative treatment for paediatric patients with poor response to oral iron therapy. However, data on the use of IV iron sucrose treatment in Chinese children remain limited.

[Comparative study on lengthened proximal femoral nail antirotation and InterTan in the treatment of subtrochanteric femur fractures in the elderly].

Objective: To investigate the clinical efficacy of lengthened proximal femoral nail antirotation (PFNA) and InterTan in the treatment of subtrochanteric femur fractures in the elderly.

Methods: A retrospective analysis was performed on the data of 65 elderly patients diagnosed with subtrochanteric femoral fractures who met the inclusion criteria between October 2016 and January 2022. The enrolled patients were categorized into two groups according to the type of internal fixation used: the lengthened proximal femoral nail antirotation(PFNA) group and the InterTan group.

Assessment of retinal and choroidal structural and microvascular changes in early diabetic retinopathy using swept-source optical coherence tomography angiography.

Objective: It was to assess changes in structural parameters in early diabetic retinopathy (DR).

Materials And Methodologies: This study is a retrospective analysis that included patients with early DR admitted to the Affiliated Third Hospital of Nantong University from January 2024 to December 2024. The participants were divided into the non-DR group (NDR group) and the non-proliferative DR group (NPDR group, which included mild, moderate, and severe subgroups) using swept-source optical coherence tomography angiography (SS-OCTA) technology.

A comparison of ultrasound-guided erector spinae plane block and epidural anesthesia for postoperative recovery in elderly individuals following laparoscopic gastrectomy: a randomized controlled trial.

Background: Erector spinae plane block (EspB) is increasingly being applied for laparoscopic radical gastrectomy as an analgesic supplement to general anesthesia. The aim of this study was to evaluate the analgesic efficacy and postoperative recovery outcomes of EspB and epidural anesthesia (EDA) in elderly patients (above 65 years-of-age) undergoing laparoscopic gastrectomy in order to determine the precise multimodal analgesia (PMA) that promotes postoperative recovery.

Methods: In total, 102 patients assigned for elective laparoscopic gastrectomy were classified into three groups: preoperative bilateral EspB with general anesthesia, EDA with general anesthesia, and general anesthesia alone.

Efficacy and safety of first-line treatments for metastatic castration-resistant prostate cancer based on phase II and III randomized controlled trials: A PROSTA-MAP systematic review and network meta-analysis.

Background: The landscape of metastatic castration-resistant prostate cancer (mCRPC) treatment has evolved greatly; however, limited data are available regarding its relative efficacy and safety. We conducted a systematic review and network meta-analysis to analyze and compare the effectiveness and safety of first-line therapies for mCRPC, particularly doublet therapy and monotherapy.

Methods: The PubMed, Embase, and Cochrane Library databases were searched from their inception until June 6, 2023.

Irradiation Stents Versus Conventional Stents for Unresectable Malignant Hilar Biliary Obstruction: A Retrospective Study.

Background: Implantation of irradiation stents demonstrates superiority over conventional metal stents in terms of stent patency and survival for patients with distal malignant biliary obstruction. Here, we aimed to explore the efficacy and advantages of irradiation stents compared with conventional metal stents in patients with unresectable malignant hilar biliary obstruction (MHBO).

Method: Unresectable MHBO patients treated with irradiation stents (IS group) were prospectively enrolled and followed up, and patients treated with conventional stents (CS group) were retrospectively enrolled by propensity score matching.

Novel Approaches in Glucose and Lipid Metabolism Disorder Therapy: Targeting the Gut Microbiota-Bile Acid Axis.

Metabolic dysregulation involving glucose and lipids is closely associated with chronic diseases such as type 2 diabetes mellitus. Emerging evidence highlights the regulatory role of bile acid (BA)-gut microbiota interactions in these metabolic disorders. The gut microbiota orchestrates the biotransformation of primary BAs into bioactive secondary BAs, which function as endocrine signaling molecules by activating the nuclear farnesoid X receptor (FXR) and G protein-coupled membrane receptor (TGR5), forming a communication network essential for metabolic homeostasis.

Freeze-induced degradation of organic micropollutants by chlorine.

Freeze-accelerated reactions mainly arise from the freeze-concentration effect, where solutes are enriched in unfrozen liquid channels between ice crystals. While chlorine (HOCl) is more abundant than iodine and bromine in environments, its reactivity under freezing conditions remains largely unexplored. This study investigates the degradation of carbamazepine (CBZ) by HOCl in ice.

Ball-milling treated superfine powdered activated carbon triggers Mn(VII) activation for enhanced oxidation of organic contaminants.

Carbocatalysts have been recently investigated to enhance the decontamination performance of permanganate (Mn(VII)) in water remediation. This study interestingly found that superfine powdered activated carbon (SPAC), stemming from low-cost powdered activated carbon (PAC) via ball milling, significantly enhanced Mn(VII) oxidation of trace organic contaminants (TrOCs). In contrast, PAC exhibited little effect in Mn(VII) activation.

Large language model-based biological age prediction in large-scale populations.

Accurate and convenient assessment of individual aging is crucial for identifying health risks and preventing aging-related diseases. Nonetheless, current aging proxies often face challenges such as methodological limitations, weak associations with adverse outcomes and limited generalizability. Here we propose a framework that leverages large language models (LLMs) to estimate individual overall and organ-specific aging using only health examination reports.

KAT5 knockdown alleviates microglial inflammatory injury following acute cerebral ischemia through enhanced STAT6 activity.

In ischemic stroke (IS), microglia exhibit dynamic functional shifts, contributing to tissue damage during the acute phase and promoting repair in the chronic phase. The mechanisms underlying these transitions are poorly understood. We utilized a KAT5 knockdown rat model in conjunction with a BV2 cell model to investigate the negative regulatory mechanism of Lysine Acetyltransferase 5 (KAT5) on Signal Transducer and Activator of Transcription 6 (STAT6) and its effects in IS.

Sleep indicators and staging: A functional near-infrared spectroscopy study in healthy young adults.

Functional near-infrared spectroscopy(fNIRS)-based sleep staging has attracted considerable interest due to its portability and limited interference with sleep. However, few studies have systematically examined sleep indicators or formulated sleep staging models based on fNIRS features labelled by polysomnography(PSG). This study aimed to address these shortcomings and promote the application of fNIRS in sleep monitoring.

Comparative formation of nitrogenous by-products in hydroxylamine-enhanced Fe(II)/PDS and Fe(II)/HO systems during contaminant degradation.

This study systematically investigated the degradation of phenolic (phenol) and aromatic carboxylic (benzoic acid (BA)) compounds and formation of nitrogenous by-products in Fe(II)-activated peroxide systems with hydroxylamine (HA). Significant differences were observed between the peroxydisulfate (PDS)-based and hydrogen peroxide (HO)-based systems. The Fe(II)/PDS/HA system produced substantial yields of nitrosated and nitrated by-products, reaching 10-35 % for phenol and 2-17 % for BA.

[Experimental study on autologous osteochondral transplantation in the treatment of recurrent anterior dislocation of the shoulder joint with articular cartilage defect in rabbits].

Objective: To explore clinical effect of autologous osteochondral transplantation (AOT) in the treatment of recurrent anterior dislocation of the shoulder joint with glenoid cartilage defect in rabbits by establishing a model of recurrent anterior dislocation of the shoulder joint with < 20% glenoid cartilage defect in rabbits.

Methods: Twenty-four male New Zealand white rabbits, aged 6-month-old, weighed (2.69±0.

Hierarchical optimization control strategy of hybrid electric vehicle platoon under communication failure.

This research proposes a DRL-based hierarchical optimization control strategy for connected HEV platoons through a cloud platform, addressing strong nonlinearity and communication failure issues. The strategy uses a signal-interference-plus-noise ratio model to detect network failures by considering distance, signal path loss, and wireless interference. The high-level control employs distributed model predictive control (DMPC) to generate desired commands for platoon driving during network failures.

The mediating role of empathy and moral sensitivity in nurses' spiritual health and spiritual caregiving competence: a cross-sectional study.

Background: There is a paucity of current research on the mechanisms that mediate the relationship between nurses' levels of spiritual health and spiritual caregiving competence.

Aim: The aim of this study was to explore the mediating role of empathy and moral sensitivity between spiritual health and spiritual caregiving competence.

Methods: A cross-sectional survey was conducted from January to December 2023 in six tertiary hospitals in Liaoning Province, China.

New insights into the role of electron shuttles in enhancing permanganate oxidation for the removal of aniline compounds: Free radicals and intermediate manganese.

Permanganate/electron shuttle systems for the enhanced transformation of anilines were evaluated. The presence of electron shuttles (2,2'-azino-bis(3-ethylbenzothiazoline)-6-sulfonate (ABTS), 1-hydroxybenzotriazole (HBT) and catechol (CAT) accelerated the oxidative transformation of aniline by Mn(VII). In the Mn(VII)/ABTS process, ABTS was partially consumed through fragmentation or polymerization with aniline, while the second-order rate constants (kapp, M s) of the interaction of ABTS with aniline rose from 86.

Directed Evolution of OgeuIscB With Enhanced Activity in Human Cells.

The miniature RNA-guided endonuclease IscB, as the evolutionary progenitor of Cas9, is attracting increased attention for genome editing due to its compact size and suitability for in vivo delivery. However, the poor editing efficiency of IscB in eukaryotic cells presents a significant challenge to its widespread application in precise site-specific human genome editing. In this study, we employed structure-guided rational design and protein engineering to optimize OgeuIscB, resulting in the identification of enIscB-F138R, which further enhanced editing activity up to 3.

Effect of Heat Treatment on Microstructure and Tensile Property of Laser-Powder-Bed-Melted Al-Mn-Mg-Sc-Zr Alloy.

This study explored the effects of T5 and T6 heat treatments on the microstructure and tensile properties of a laser powder bed fusion (LPBF)-fabricated Al-Mn-Mg-Sc-Zr alloy. The as-built condition exhibited a bi-modal grain structure of equiaxed and columnar grains. Specimens after T5 heat treatment also had a bi-modal microstructure with slight grain growth and the precipitation of secondary AlSc, which enhanced the yield strength via precipitation hardening but reduced ductility.

Associations of exposure to polycyclic aromatic hydrocarbons with hearing in U.S. Adults.

Polycyclic aromatic hydrocarbons (PAHs) pollution and hearing loss are important issues in the environment and public health. However, current research still lacks data on their association in real-world environments. This study included 658 American adults who participated in the National Health and Nutrition Examination Survey (NHANES) from 2015 to 2016.

Diffuse Erythematous Follicular Eruption Induced by Pegylated Liposomal Doxorubicin.

Pegylated liposomal doxorubicin (PLD) is a form of doxorubicin enclosed in pegylated liposomes and is associated with a high risk of mucocutaneous side effects. The most common cutaneous side effect is hand-foot syndrome, whereas other cutaneous reactions are rarely reported. The pathogenesis of PLD-induced cutaneous reaction is not yet clear.

The role of biochar in algal source water treatment: Algal cells integrity and N-Nitrosodimethylamine (NDMA) formation potential.

The effects of unmodified and modified biochars (BC) made by tea (TBC), coconut shell (NBC), corn straw (SBC), and orange peel (OBC) on algae removal efficiency and NDMA formation potential (NDMA-FP) in algae-containing water were investigated. The algae removals (12 %-45 %) and NDMA-FP reductions (1 %-20 %) were enhanced by unmodified BC, indicating that the potential application of BC in algae removal and NDMA formation risk control. Cu(Ⅰ/Ⅱ)-modified BC (Cu(Ⅰ/Ⅱ)-BC) significantly promoted algae removal efficiency (up to 80 %) with the most significant physical membrane damage to Microcystis aeruginosa (85-99 %), leading to an increase in NDMA-FP (21 %-31 %).