Zinc-α2-glycoprotein relieved seizure-Induced neuronal glucose uptake impairment via insulin-like growth factor 1 receptor-regulated glucose transporter 3 expression.

Glucose hypometabolism is observed in epilepsy and promotes epileptogenesis. Glucose hypometabolism in epilepsy may be attributed to decreased neuronal glucose uptake, but its molecular mechanism remains unclear. Zinc-α2-glycoprotein (ZAG) is related to glucose metabolism and is reported to suppress seizures.

Mn effect on manganese oxides (MnO) nanoparticles aggregation in solution: Chemical adsorption and cation bridging.

Manganese oxides (MnO) and Mn usually co-exist in the natural environment, as well as in water treatments for Mn removal. Therefore, it is necessary to investigate the influence of Mn on the stability of MnO nanoparticles, as it is vital to their fate and reactivity. In this study, we used the time-resolved dynamic light scattering technique to study the influence of Mn on the initial aggregation kinetics of MnO nanoparticles.

Sulfite enhanced transformation of iopamidol by UV photolysis in the presence of oxygen: Role of oxysulfur radicals.

UV/sulfite process in the absence of oxygen was previously applied as an advanced reduction process for the removal of many halogenated organics and inorganics in water and wastewater. Here, it was found that UV/sulfite process in the presence of oxygen could act as an advanced oxidation process. Specifically, the oxysulfur radicals (including sulfate radical (SO) and sulfite/peroxomonosulfate radicals (SO/SO)) played important roles on the degradation of iopamidol (IPM) as a typical iodinated contrast media (ICM).

Hydroxylamine driven advanced oxidation processes for water treatment: A review.

Hydroxylamine (HA) driven advanced oxidation processes (HAOPs) for water treatment have attracted extensive attention due to the acceleration of reactive intermediates generation and the improvement on the elimination effectiveness of target contaminants. In this review, HAOPs were categorized into three parts: (1) direct reaction of HA with oxidants (e.g.

[Review of cognitive enhancement techniques based on the combination of cognitive training and transcranial direct current stimulation].

Cognitive enhancement refers to the technology of enhancing or expanding the cognitive and emotional abilities of people without psychosis based on relevant knowledge of neurobiology. The common methods of cognitive enhancement include transcranial direct current stimulation (tDCS) and cognitive training (CT). tDCS takes effect quickly, with a short effective time, while CT takes longer to work, requiring several weeks of training, with a longer effective time.

Nonradical Oxidation of Pollutants with Single-Atom-Fe(III)-Activated Persulfate: Fe(V) Being the Possible Intermediate Oxidant.

When applied for the remediation of polluted water/soil, peroxydisulfate (PDS) usually needs to be effectively activated to generate sulfate radical as the working oxidant. However, a significant part of the oxidation capacity of PDS is lost in this way because sulfate radical unselectively reacts with most of the substances in water/soil. PDS activation without generating radicals is preferred to maximize its oxidation capacity for targeted pollutants.

Review on UV/sulfite process for water and wastewater treatments in the presence or absence of O.

Based on previous reports, UV/sulfite process is generally used as an advanced reduction process (ARP) since e and/or ∙H, both with strong reduction potential, could be substantially generated herein. Very recently, the combination of UV and sulfite as an advanced oxidation process (AOP) or an oxidation-reduction coupling process has attracted increasing interest due to the yield of SO and/or HO∙. Herein, the application of UV/sulfite as an ARP and AOP (or oxidation-reduction coupling process) during water and wastewater treatments is reviewed respectively.

Chlorination and bromination of olefins: Kinetic and mechanistic aspects.

Hypochlorous acid (HOCl) is typically assumed to be the primary reactive species in free available chlorine (FAC) solutions. Lately, it has been shown that less abundant chlorine species such as chlorine monoxide (ClO) and chlorine (Cl) can also influence the kinetics of the abatement of certain organic compounds during chlorination. In this study, the chlorination as well as bromination kinetics and mechanisms of 12 olefins (including 3 aliphatic and 9 aromatic olefins) with different structures were explored.

Exploring gene-gene interaction in family-based data with an unsupervised machine learning method: EPISFA.

Gene-gene interaction (G × G) is thought to fill the gap between the estimated heritability of complex diseases and the limited genetic proportion explained by identified single-nucleotide polymorphisms. The current tools for exploring G × G were often developed for case-control designs with less considerations for their applications in families. Family-based studies are robust against bias led from population stratification in genetic studies and helpful in understanding G × G.

Apelin/Apelin receptor: A new therapeutic target in Polycystic Ovary Syndrome.

Polycystic ovary syndrome (PCOS) is an endocrinopathy, and it accounts for 75% of non-ovulatory infertile in women of childbearing age. It is clear that obesity, insulin resistance, dyslipidaemia coexist in PCOS. Apelin, as an endogenous ligand of the previously orphan receptor, is an adipokine that secreted by adipose tissue.

Mex3a interacts with LAMA2 to promote lung adenocarcinoma metastasis via PI3K/AKT pathway.

Lung adenocarcinoma (LUAD) is the main subtype of lung cancer. In this study, we found that RBP Mex3a was significantly upregulated in LUAD tissues and elevated Mex3a expression was associated with poor LUAD prognosis and metastasis. Furthermore, we demonstrated that Mex3a knockdown significantly inhibited LUAD cell migration and invasion in vitro and metastasis in nude mice.

Design, synthesis and biological evaluation of novel HDAC inhibitors with improved pharmacokinetic profile in breast cancer.

The dysfunction of histone deacetylase (HDACs) is closely related to tumorigenesis and development, which has been emerged as an attractive drug design target for cancer therapy. In the present study, we designed and synthesized a series of novel HDAC inhibitors using a substituted quinazoline as the capping group and attaching 3, 5-dimethylbenyl as a potential metabolic site protector. 23g and 23h were demonstrated potent HDAC inhibitory activities and anti-proliferative effects against MDA-MB-231 cells.

The aggregation kinetics of manganese oxides nanoparticles in Al(III) electrolyte solutions: Roles of distinct Al(III) species and natural organic matters.

This study explored the aggregation kinetics of manganese oxides (MnO) nanoparticles in Al(III) electrolyte solutions. This is a common process in both water treatments and the natural environment. The results show that aggregation kinetics are Al(III) species-dependent.

Design, synthesis and biological evaluation of 2-indolinone derivatives as PAK1 inhibitors in MDA-MB-231 cells.

P21-activated kinase 1 (PAK1) plays a vital role in the proliferation, survival and migration of cancer cells, which has emerged as a promising drug target for cancer therapy. In this study, a series of 2-indolinone derivatives were designed and synthesized through a structure-based strategy. A potent PAK1 inhibitor (ZMF-005) was discovered, which presented an IC value of 0.

Transformation of X-ray contrast media by conventional and advanced oxidation processes during water treatment: Efficiency, oxidation intermediates, and formation of iodinated byproducts.

X-ray contrast media (ICM), as the most widely used intravascular pharmaceuticals, have been frequently detected in various environmental compartments. ICM have attracted increasingly scientific interest owing to their role as an iodine contributor, resulting in the high risk of forming toxic iodinated byproducts (I-BPs) during water treatment. In this review, we present the state-of-the-art findings relating to the removal efficiency as well as oxidation intermediates of ICM by conventional and advanced oxidation processes.

The relationship between maternal vitamin D deficiency and glycolipid metabolism and adverse pregnancy outcome.

Objective: Maternal vitamin D deficiency is associated with glucose and lipid metabolism in the mother and offspring. Meanwhile, it can also lead to adverse pregnancy outcomes. The aim of this case-control study was to document maternal, umbilical arterial glucose and lipid metabolic levels and correlations in pregnancies with or without vitamin D deficiency, while also investigating adverse pregnancy outcomes.

Effect of Ultrasonic Surface Impact on the Fatigue Properties of Ti3Zr2Sn3Mo25Nb.

The effect of nano grain surface layer generated by ultrasonic impact on the fatigue behaviors of a titanium alloy Ti3Zr2Sn3Mo25Nb (TLM) was investigated. Three vibration strike-numbers of 24,000 times, 36,000 times and 48,000 times per unit are chosen to treat the surface of TLM specimens. Nanocrystals with an average size of 30 nm are generated.

Seizure-induced impairment in neuronal ketogenesis: Role of zinc-α2-glycoprotein in mitochondria.

Ketone bodies (KBs) were known to suppress seizure. Untraditionally, neurons were recently reported to utilize fatty acids and produce KBs, but the effect of seizure on neuronal ketogenesis has not been researched. Zinc-α2-glycoprotein (ZAG) was reported to suppress seizure via unclear mechanism.

Gilgamesh (Gish)/CK1γ regulates tissue homeostasis and aging in adult Drosophila midgut.

Adult tissues and organs rely on resident stem cells to generate new cells that replenish damaged cells. To maintain homeostasis, stem cell activity needs to be tightly controlled throughout the adult life. Here, we show that the membrane-associated kinase Gilgamesh (Gish)/CK1γ maintains Drosophila adult midgut homeostasis by restricting JNK pathway activity and that Gish is essential for intestinal stem cell (ISC) maintenance under stress conditions.

The Paradox Association between Smoking and Blood Pressure among Half Million Chinese People.

: The association between smoking and blood pressure (BP) has been explored extensively, yet the results remain inconclusive. Using real-world evidence of a large Chinese population, we examine the effect of smoking on BP levels. : We utilize half a million adults from the China Kadoorie Biobank (CKB) study with baseline sampling collected between 2004 and 2008.

[Down-regulated expression of Sall1 and enhanced expression of inflammatory factors in dorsal horn of spinal cord of mice with sciatic nerve branch selective injury].

Objective To investigate the expression and distribution of spalt-like transcription factor 1 (Sall1) in the lumbar spinal dorsal horn of mice with sciatic nerve branch selective injury. Methods BALB/c mice aged 6~8 weeks old were randomly divided into a control group, a sham operation group and a sciatic nerve branch selective injury group. The mechanical withdrawal threshold (MWT) was measured on the 1st day before the establishment of the model and on the 3rd, 7th, 10th and 14th day after operation.

Thallium(I) Oxidation by Permanganate and Chlorine: Kinetics and Manganese Dioxide Catalysis.

The oxidation of the toxic heavy metal thallium(I) (Tl(I)) is an efficient way to enhance Tl removal from water and wastewater. However, few studies have focused on the kinetics of Tl(I) oxidation in water, especially at environmentally relevant pH values. Therefore, the kinetics and mechanisms of Tl(I) oxidation by the common agents KMnO and HOCl under environmentally relevant pH condition were explored in the present study.