Efficacy and safety of Belimumab, Rituximab and Voclosporin in the treatment of lupus nephritis based on registered clinical trials: A systematic review and network meta-analysis.

ObjectiveTo systematically compare the clinical effectiveness and safety of Belimumab, Rituximab and Voclosporin in the treatment of lupus nephritis based on network meta-analysis method.MethodsSystematic search of registered clinical trials in four major databases (Pubmed, Embase, Web of Science, The Cochrane Register of Clinical Trials) and ClinicalTrials.gov.

Clinical study on localization of calcific tendinitis of the supraspinatus tendon based on three-dimensional reconstruction technology of CT scan.

Background: Arthroscopic resection of calcific lesions is an effective treatment for calcific tendonitis. However, accurately locating the calcific foci can be challenging. In this study, we propose the use of preoperative 3D-CT scan technology combined with intraoperative patient position and markings to precisely locate intraoperative lesions.

Design and Synthesis of Box[6]arenes for 3D Charge-Transfer Co-Crystal Engineering via Macrocyclic Self-Complementary and Exo-Wall Interactions.

The construction of well-defined 3D charge-transfer (CT) co-crystals using new macrocyclic hosts to enable programmable functionality remains challenging due to the dimensional constraints imposed by conventional assembly strategies. Herein, we address this limitation using a new synthetic macrocycle named box[6]arene (B[6]A) with a flexible skeleton, which adopts two distinct conformations (B[6]Aα and B[6]Aβ). Crucially, the self-complementary and exo-wall CT co-assembly of B[6]A facilitates the construction of 3D macrocycle-based co-crystals (MCCs) with planar electron-deficient guests, including 1,2,4,5-tetracyanobenzene (TCNB), tetrafluoroterephthalonitrile (TFTN), and tetrachloroterephthalonitrile (TClTN).

Dual-Functional AgNPs/Magnetic Coal Fly Ash Composite for Wastewater Disinfection and Azo Dye Removal.

In this study, we report the development of a novel magnetized coal fly ash-supported nano-silver composite (AgNPs/MCFA) for dual-functional applications in wastewater treatment: the efficient degradation of methyl orange (MO) dye and broad-spectrum antibacterial activity. The composite was synthesized via a facile impregnation-reduction-sintering route, utilizing sodium citrate as both a reducing and stabilizing agent. The AgNPs/MCFA composite was systematically characterized through multiple analytical techniques, including Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and vibrating sample magnetometry (VSM).

A Novel Score for Predicting Long-Term Outcomes in Recanalisation-Treated Patients With Budd-Chiari Syndrome: A Multicentre Study.

Background And Aims: A recanalisation-specific model for Budd-Chiari syndrome (BCS) is lacking. We aimed to develop a novel score for individual long-term outcome prediction and risk stratification.

Methods: Overall, 834 BCS patients undergoing recanalisation (566 received percutaneous transluminal angioplasty alone, and 268 with routine stenting) from January 2010 to May 2019 were included from six Chinese centres.

Irradiation Stents Versus Conventional Stents for Unresectable Malignant Hilar Biliary Obstruction: A Retrospective Study.

Background: Implantation of irradiation stents demonstrates superiority over conventional metal stents in terms of stent patency and survival for patients with distal malignant biliary obstruction. Here, we aimed to explore the efficacy and advantages of irradiation stents compared with conventional metal stents in patients with unresectable malignant hilar biliary obstruction (MHBO).

Method: Unresectable MHBO patients treated with irradiation stents (IS group) were prospectively enrolled and followed up, and patients treated with conventional stents (CS group) were retrospectively enrolled by propensity score matching.

Interventional Radiological Management for Budd-Chiari Syndrome: A 10-Year Retrospective, Multicenter Survey on 997 Patients in China.

Background And Aims: Large-scale cohort studies on interventional radiological treatments for Budd-Chiari syndrome (BCS), including percutaneous angioplasty (PTA) with or without routine stenting and transjugular intrahepatic portosystemic shunt (TIPS), are lacking. We aimed to evaluate the long-term outcomes of these treatments in Chinese BCS patients.

Methods: Consecutive patients diagnosed with BCS in 6 Chinese tertiary centers were retrospectively screened for eligibility between January 2010 and May 2019.

Public Versus Academic Discourse on ChatGPT in Health Care: Mixed Methods Study.

Background: The rapid emergence of artificial intelligence-based large language models (LLMs) in 2022 has initiated extensive discussions within the academic community. While proponents highlight LLMs' potential to improve writing and analytical tasks, critics caution against the ethical and cultural implications of widespread reliance on these models. Existing literature has explored various aspects of LLMs, including their integration, performance, and utility, yet there is a gap in understanding the nature of these discussions and how public perception contrasts with expert opinion in the field of public health.

Induction With Antithymocyte Globulin Is Associated With Decreased Mortality and PTLD in Pediatric Liver Transplantation: A UNOS Data Analysis.

Background: Immunosuppressive therapy for pediatric liver transplant recipients varies between institutions. We aim to compare outcomes associated with common induction agents and maintenance therapies.

Methods: A retrospective analysis of the United Network for Organ Sharing database was performed for pediatric liver transplant cases between 2010 and 2024.

Combined Thymoglobulin and Interleukin-2 Receptor Antagonist Induction Therapy in Kidney Transplantation Is Associated With Worse Delayed Graft Function, Acute Rejection, Graft Loss, and Mortality.

Introduction: Single-agent induction with either Thymoglobulin (ATG), alemtuzumab, or interleukin-2 receptor antibodies (IL2Ra) is a standard of immunosuppression during kidney transplantation (KTX). Dual-induction therapy (DIT) with ATG + IL2Ra is occasionally administered as part of a center-specific protocol or salvage following failed ATG or IL2Ra induction. We report the outcomes of single-agent regimens versus DIT.

Cathode-Electrolyte Interphase Engineering through Artificial Surface Coating in 4.55 V High-Voltage LiCoO Cathodes.

Increasing the high cutoff potential of LiCoO (LCO) has proven challenging, due to lattice structure deterioration and cathode electrolyte interphase (CEI) instability. This work reports an effective strategy for tuning the CEI and stabilizing the cathode surface structure; we used atomic layer deposition (ALD) to synthesize AlO-capped LCO (ACLCO). Direct cryogenic transmission electron microscopy (cryo-TEM) characterization of the CEI reveals that, at 4.

Implementing large language model and retrieval augmented generation to extract geographic locations of illicit transnational kidney trade.

Background: Illicit kidney trade networks, operating globally, involve intricate interactions among various players, most notably buyers, sellers, brokers, and surgeons. A comprehensive understanding of these trade networks is, however, hindered by the lack of systematically amassed data for analysis. Further, extracting the geographic locations of buyers, sellers, brokers, transplant surgeons, and medical facilities in all relevant publications often involves extensive, time-consuming, manual labelling that is very costly.

Proton-Mediated ROS Amplification in Hydrazone-Linked Pillararene Microspheres for Photocatalysis.

Smart materials that adapt to environmental stimuli have massive technological potential. Translating well-established molecular-level responsiveness to macroscopic systems, particularly complex systems for photocatalysis, remains a significant hurdle. Herein, we introduce a new approach using a hydrazone-linked pillararene microsphere (NP5-TF-HPM) as a smart stimuli-responsive photocatalyst.

Regulating Enol-to-Keto Tautomerization of Pillararene-Based Conjugated Macrocycle Polymers for HO Photosynthesis.

Porous organic polymers have emerged as promising materials for energy conversion, pollutant adsorption, and heterogeneous catalysis because of their tunable pore structures and high surface areas. However, most porous organic polymers are still limited by insufficient conjugation and inefficient electron-hole separation, hindering the tunability of their photoelectric properties and overall functionality. By integrating macrocyclic compounds as a new building block, which feature electron-rich cavities and rigid ring structures, into the polymer network, the resulting conjugated macrocycle polymers are expected to provide an innovative approach to enrich the photoelectric functionalities of porous organic polymers.

Adult Only Intestinal Retransplant Is Associated With Higher Rates of Graft Failure, Acute Rejection, and Mortality: A United Network for Organ Sharing Database Analysis.

Objectives: Adult intestinal retransplant has increased substantially during the past decade, outpacing the rate of primary transplants to become the fourth most common reason for intestinal transplant. Although intestinal retransplant is a viable option for patients with failed transplants, long-term survival is often lower. We compared intestinal retransplant to primary intestinal transplant for rates of graft failure, acute rejection, and mortality.

Effects of Combined Versus Single Supplementation of Creatine, Beta-Alanine, and L-Citrulline During Short Sprint Interval Training on Basketball Players' Performance: A Double-Blind Randomized Placebo-Controlled Trial.

Purpose: Athletes often use sport supplements to improve their physical and physiological performance. This randomized, double-blind, placebo (PL) -controlled study aimed to investigate the effects of combined versus single supplementation of creatine (Cr), beta-alanine (BA), and L-citrulline (L-Cit) during short sprint interval training (SSIT) on basketball players' physical and physiological performance over a period of 28 days.

Methods: Forty-eight basketball players were equally assigned to 6 groups of Cr (0.

Efficacy and Safety of Interleukin-17 and Janus Kinase Inhibitors in Ankylosing Spondylitis: A Systematic Review and Network Meta-Analysis.

Introduction: The aim of this study was to compare the clinical efficacy and safety of interleukin-17 inhibitors and Janus kinase (JAK) inhibitors in the treatment of ankylosing spondylitis (AS) based on a network meta-analysis (NMA).

Methods: According to the search strategy, systematic searches were conducted in PubMed, Embase, Web of Science, the Cochrane Register of Clinical Trials, Scopus, and View Article and Find Full Text PDF

Induction outcomes in adult kidney transplantation: Two decades of UNOS data analysis.

Objectives: In the US, 92 % of kidney transplant recipients are treated with induction therapy. This analysis assesses the impact of induction immunosuppression on outcomes such as graft failure, patient mortality, and length of hospitalization.

Material And Methods: Retrospective analysis of the UNOS database in adults who received a kidney transplant from January 2000 to June 2022.

Cathode-Electrolyte Interphase of Ni-Rich Layered Oxides: Evolving Structure and Implication on Stability.

The cathode-electrolyte interphase (CEI) is recognized as a crucial component in battery systems; however, knowledge regarding its structure and function remains limited and often controversial. This study demonstrates the feasibility of revealing atomic-resolution CEI structures via cryogenic transmission electron microscopy (cryo-TEM). Using Ni-rich oxide (LiNiCoMnO, NCM811) microparticles as the model cathode, ultrafine images of CEI were obtained, revealing its dynamic evolution over cycling and its impact on battery performance.

Winter forage crops influence soil properties through establishing different arbuscular mycorrhizal fungi communities in paddy field.

Winter planting is promising for improving the utilization rate of fallow paddy fields in southern China by establishing arbuscular mycorrhizal fungi (AMF) communities. However, the effects of different winter forage crops on AMF community construction remain unknown. The AMF community establishment of different winter planting forage crops were conducted in oat, rye, Chinese milk vetch, and ryegrass, with winter fallow as a control.

Synergistic Modulation of Solid- and Cathode-Electrolyte Interphase via a Lithium Salt Additive toward Stable Sodium Metal Batteries.

Constructing feasible sodium metal batteries (SMBs) faces complex challenges in stabilizing cathodes and sodium metal anodes. It is imperative, but often underemphasized, to simultaneously regulate the solid-electrolyte interphase (SEI) to counter dendrite growth and the cathode-electrolyte interphase (CEI) to mitigate cathode deterioration. Herein, we introduce lithium 2-trifluoromethyl-4,5-dicyanoimidazolide (LiTDI) as an efficacious additive in a carbonate-based electrolyte to extend cycle lifespan of full SMBs: the capacity retention reaches 77.

Comparative analysis of ischemic and hemorrhagic stroke hospitalization rates in end-stage kidney disease and kidney transplant patients with and without atrial fibrillation.

Introduction: Atrial fibrillation (AF) in end-stage kidney disease (ESKD) and kidney transplant (KTx) recipients presents challenges in stroke risk management. This study aimed to compare hospitalization rates for ischemic and hemorrhagic cerebrovascular events in ESKD and KTx patients with and without AF.

Methods: Using the National Inpatient Sample (2005-2019), retrospective analysis was conducted on hospitalizations for ESKD and KTx patients with and without AF.