Dysregulation of lncRNA OIP5-AS1 participants in the progression of diabetic retinopathy and affects the proliferation in retinal vascular endothelial cell.

Aims: This study was to ascertain the clinical performance of OIP5-AS1 in diabetic retinopathy (DR) and its molecular mechanism in the disease progression.

Materials And Methods: Subjects included 85 healthy controls, 79 patients with type 2 diabetes mellitus (T2DM), and 114 T2DM-DR patients. qRT-PCR was conducted to measure the relative abundances of OIP5-AS1 and miR-181a-5p in the research subjects.

Case Report: Pediatric acute suppurative thyroiditis caused by : a rare presentation revealing pyriform sinus fistula.

Acute suppurative thyroiditis (AST) is a rare, potentially life-threatening bacterial infection of the thyroid gland, characterized by rapid progression. We report a rare pediatric case of AST caused by , secondary to a pyriform sinus fistula (PSF), initially misdiagnosed as subacute thyroiditis (SAT). A retrospective analysis highlights the diagnostic challenges and emphasizes the need for early suspicion of PSF in recurrent AST.

The effects of fluoxetine on body weight, waist circumference, and body mass index in individuals who are overweight or have obesity: a meta-analysis of randomized controlled trials.

The effect of fluoxetine administration on body weight (BW), waist circumference (WC), and body mass index (BMI) remains inconclusive, as many studies have reported contradicting results. We conducted a meta-analysis of randomized controlled trials (RCTs) to assess the impact of fluoxetine prescription on these anthropometric indices. A comprehensive systematic review was conducted in PubMed/MEDLINE, SCOPUS, Web of Science, and EMBASE for manuscripts indexed before Jun 28st, 2025.

Multiplexing and Demultiplexing of Aperture-Modulated OAM Beams.

A multiplexing method for orbital angular momentum (OAM) beams was proposed. The aperture size as a new information carrier was provided, and it could be modulated by the external variable aperture. The field of the beams propagating through turbulence was derived and discretized with Gauss-Legendre quadrature formulas.

-Phosphinoylaminophthalimide: a phosphinoyl radical precursor applied in phosphinoyl-substituted phenanthridine and ketone synthesis.

A new phosphinoyl radical precursor, -phosphinoylaminophthalimide (PAPI), was developed. The precursor exhibits several practical advantages: facile synthesis from commercially available starting materials, cost-effectiveness at scale, and excellent air and moisture stability under ambient storage conditions. Phosphinoyl radical was generated under basic and oxidative conditions, and captured by isonitrile and olefin, yielding phosphinoyl-substituted phenanthridines and α-phosphinoyl ketones, respectively.

Synthesis of Furan-Tethered Benzocyclobutenes via Protonic Acid-Catalyzed 1,4-Sulfinate Migration-Annulation.

A protonic acid-catalyzed cascade of conjugated enynones was realized for synthesizing multisubstituted furans containing benzocyclobutene with high yields and simple procedures. Employing inexpensive sulfanilic acid as a catalyst, this method features a key 1,4-sulfinate migration and avoids the use of transition metal catalysts. Substrates that are unreactive under metal-mediated catalysis are applicable due to proton transfer processes.

Metabolite 2-aminoadipic acid: implications for metabolic disorders and therapeutic opportunities.

Previous evidence has indicated that the role of 2-aminoadipic acid (2-AAA), a derivative of lysine catabolism, in mediating specific detrimental effects on glial cells, notably inhibiting astrocyte activation. In addition, intrathecal administration of 2-AAA has demonstrated significant efficacy in relieving mechanical hyperalgesia. With the growing application of metabolomics in biomedical research, substantial evidence now underscores 2-AAA's pivotal role in regulating glucose and lipid metabolism.

Evaluation and comparison of inflammatory and insulin resistance indicators on recurrent cardiovascular events in patients undergoing percutaneous coronary intervention: a single center retrospective observational study.

Background: The aim of this study was to evaluate and compare the usefulness of the C-reactive protein (CRP)-triglyceride glucose (TyG) index (CTI) and other insulin resistance (IR) or inflammatory indexes for predicting recurrent cardiovascular events in percutaneous coronary intervention (PCI)-treated patients. In addition, the mediating effects of systemic inflammation, represented by high-sensitive CRP (hs-CRP), on TyG index-associated adverse cardiovascular events across different subgroups were also evaluated.

Methods: The formula for calculating the CTI was 0.

Proton-Mediated ROS Amplification in Hydrazone-Linked Pillararene Microspheres for Photocatalysis.

Smart materials that adapt to environmental stimuli have massive technological potential. Translating well-established molecular-level responsiveness to macroscopic systems, particularly complex systems for photocatalysis, remains a significant hurdle. Herein, we introduce a new approach using a hydrazone-linked pillararene microsphere (NP5-TF-HPM) as a smart stimuli-responsive photocatalyst.

A systematic review and meta-analysis of the efficacy and safety of glucocorticoids in the treatment of severe pneumonia.

Objectives: To systematically evaluate the efficacy and superiority of glucocorticoids in the treatment of severe pneumonia.

Method: Randomized Controlled Trials (RCTs) on glucocorticoids in the treatment of severe pneumonia were retrieved from CNKI, CBM, China Science and Technology Journal Database (VIP), Wanfang Database, and PubMed as of January 1, 2017. The literature was independently and objectively screened, extracted, and evaluated by two researchers, and a meta-analysis of the extracted data was performed using Revman 5.

Exercise-Mediated Mechanical Stress Promotes Osteogenic Differentiation of BMSCs Through Upregulation of Lactylation via the IER3/LDHB Axis.

Despite decades of research, senile osteoporosis still lacks effective treatments. Exercise-mediated mechanical loading enhances bone density, strength, and microstructure, while lack of exercise leads to significant bone loss. In this study, we used treadmill exercise and tail-suspension mouse models to explore the effects of exercise on bone metabolism.

Highly Sensitive Thianthrene Covalent Trimer Room-Temperature Phosphorescent Materials for Low-Concentration Oxygen Detection.

Oxygen is ubiquitous and vital to life, industry, and environmental safety, so accurate and reliable oxygen sensing and detection are of great significance, especially for oxygen in the low concentration range. Herein, two pure organic metal-free room-temperature phosphorescence (RTP) materials were developed using a covalent trimerization strategy of thianthrene (TA), which exhibit high oxygen sensitivity and fluorescence-RTP separated dual emission due to the moderate spin-orbit coupling (SOC). Compared with traditional metal-organic complexes, the oxygen sensitivity of RTP is improved by about two orders of magnitude, especially facilitating accurate quantitative detection of low-concentration oxygen.

Ultralong Room Temperature Phosphorescence through Both Space Confinement and Long-Range Charge Migration.

Doping guest materials into host materials with a confined space to suppress nonradiative decay is an effective strategy for achieving room-temperature phosphorescence (RTP). However, constructing host-guest doped materials with ultralong RTP (URTP) is still challenging. Herein, by embedding three coumarin derivatives into boric acid via one-step heat treatment, the URTP material with an afterglow lasting up to 60 s, a phosphorescence lifetime of 1.

Identification of NIBAN2-Regulated RUNX2 Alternative Splicing Presents Novel Strategies for Antagonizing Osteoporosis.

Osteoporosis is characterized by excessive bone resorption and/or defects in bone formation. Identification of factors promoting osteoblast differentiation may provide potential targets for osteoporosis therapy. Through integral analyses of multiple datasets, NIBAN2 is found to be tightly associated with bone formation and osteoporosis.

[Three-dimensional human-robot mechanics modeling for dual-arm nursing-care robot transfer based on individualized musculoskeletal multibody dynamics].

During transfer tasks, the dual-arm nursing-care robot require a human-robot mechanics model to determine the balance region to support the patient safely and stably. Previous studies utilized human-robot two-dimensional static equilibrium models, ignoring the human body volume and muscle torques, which decreased model accuracy and confined the robot ability to adjust the patient's posture in three-dimensional spatial. Therefore, this study proposes a three-dimensional spatial mechanics modeling method based on individualized human musculoskeletal multibody dynamics.

Dual-Function Strategy for Enhanced Quercetin Detection Using Terbium(III) Ion-Bound Gold Nanoclusters.

The engineering of metal nanoclusters (NCs) that exhibit bright emissions and high sensing performance under physiological conditions is still a formidable challenge. In this study, we report a novel design strategy for realizing excellent performance metal NC-based probes by leveraging both concerted proton-coupled electron transfer (PCET) and photoinduced electron transfer (PET) mechanisms, with terbium(III) (Tb) ions serving as a key modulator. Our findings indicate that the binding of Tb ions to the 6-aza-2-thiothymidine (ATT) ligand effectively inhibits the proton-transfer step in the concerted PCET pathway of Au(ATT) NCs, giving rise to over a 10-fold enhancement in fluorescence and a quantum yield of 7.

Fast Registration Algorithm for Laser Point Cloud Based on 3D-SIFT Features.

In response to the issues of slow convergence and the tendency to fall into local optima in traditional iterative closest point (ICP) point cloud registration algorithms, this study presents a fast registration algorithm for laser point clouds based on 3D scale-invariant feature transform (3D-SIFT) feature extraction. First, feature points are preliminarily extracted using a normal vector threshold; then, more high-quality feature points are extracted using the 3D-SIFT algorithm, effectively reducing the number of point cloud registrations. Based on the extracted feature points, a coarse registration of the point cloud is performed using the fast point feature histogram (FPFH) descriptor combined with the sample consensus initial alignment (SAC-IA) algorithm, followed by fine registration using the point-to-plane ICP algorithm with a symmetric target function.

Degradation Mechanism of TOPCon Solar Cells in an Ambient Acid Environment.

n-Type tunnel oxide passivated contact (TOPCon) solar cells are expected to dominate the global photovoltaic market in the next decade, primarily owing to their rapidly increasing power conversion efficiency (PCE). However, acids generated from encapsulant hydrolysis under damp-heat (DH) conditions significantly impair the reliability of TOPCon solar cells. This study evaluated the degradation behavior of TOPCon solar cells under an accelerated test in an ambient acid environment.

Microenvironment-Responsive Hydrogels Comprising Engineering Zeolitic Imidazolate Framework-8-Anchored Parathyroid Hormone-Related Peptide-1 for Osteoarthritis Therapy.

Intra-articular drug injections are effective for osteoarthritis (OA), but challenges such as the complex microenvironment and rapid drug diffusion require frequent injections. Herein, we propose a biofunctional hydrogel-based strategy for prolonged drug delivery and microenvironment remodeling. We propose a strategy to functionalize zeolitic imidazolate framework-8 with tannic acid (TA-ZIF), anchor PTH-related peptide-1 (PTHrP-1) within this framework (TA-ZIF@P1) and incorporate a phenylboronic acid-modified gelatin-based hydrogel (GP hydrogel) drug delivery system (GP@TA-ZIF@P1, GPTP hydrogel) with responsive release properties that respond to the pathological microenvironments of OA.

Advanced measurement methods for high-power gallium nitride high electron mobility transistors.

The testing and modeling of semiconductor devices are the foundation of circuit design. The issue of high-power device testing urgently needs to be solved as the power level of the devices under test (DUTs) increases. This work proposes advanced measurement methods based on three aspects of "measuring capability, security, and stability" with a focus on the features of high output power, easy self-oscillation in mismatch tests, and safety risk in the measurement system of high-power transistors.

A comparative investigation on excimer fluorescence toward its bright future.

Must excimers quench fluorescence? This study aims to clarify the misconception that excimers are defective species with weak fluorescence. For this purpose, we utilized a rigid xanthene template to connect anthracene units for constructing an inter-excimer and an intra-excimer. Their photophysical properties were systematically investigated in solution and crystal forms, representing dynamic and static environments, respectively.

The Role of Open-Shell Organic Radical in Enhancing Anti-Tumor Photocatalysis Reaction of NIR Light-Activated Photosensitizer.

Open-shell radical materials, which are characterized by unpaired electrons, have led to revolutionary breakthroughs in material science due to their unique optoelectronic properties. However, the involvement of organic radicals in photodynamic therapy (PDT) has rarely been reported or discussed. This work studies two photosensitizer analogs.

Platinum nanozyme embedded in hyaluronate with multifunctional attributes synergistically promoting tracheal fistula healing.

Respiratory tract fistulas, including tracheal and bronchial fistulas, usually cause prolonged hospitalization with developed complications and even death, while respiratory tract fistula healing remains challenging. Exploring effectiveness and mechanism in animal systems using well-designed bio-nanomaterials will improve our understanding of fistula management. Hyaluronate (hyaluronan or hyaluronic acid) has been widely studied as a promising coating material for bio-nanomaterials in treatment applications.

Effect of structure and interaction on physicochemical properties of new [Emim][BFX] complex anion ionic liquids studied by quantum chemistry.

Context: One of the key challenges in the industrial application of ionic liquids (ILs) is their extreme characteristics, such as viscosity, glass transition temperatures, and conductivity. Understanding the relationship between ILs structure and physicochemical property is a crucial aspect of the directed design of ILs with good properties, which is a prerequisite for their successful implementation in industrial processes. In this work, high-level quantum-chemical research with for four pairs ionic liquids, [Emim][X] and [Emim][BFX] (X = CHSO, EtSO, HSO, Tos), was performed, to analyze the stable structure, interionic interaction, and charge transfer and provide a new insight into the property variances at the molecular level.

Congruent Long-Term Declines in Carbon and Biodiversity Are a Signature of Forest Degradation.

Recent global policy initiatives aimed at reducing forest degradation require practical definitions of degradation that are readily monitored. However, consistent approaches for monitoring forest degradation over the long term and at broad scales are lacking. We quantified the long-term effects of intensive wood harvest on above-ground carbon and biodiversity at fine resolutions (30 m) and broad scales (New Brunswick, Canada; 72,908 km).