Impact of physical exercise habit on career decision-making behavior in college students: a chain mediating effect of self-efficacy and psychological resilience.

Objective: To explore the mechanism through which physical exercise habits influence college students' career decision-making behavior, and to verify the independent and chain mediation effects of self-efficacy and psychological resilience within this relationship.

Methods: Using stratified random sampling, questionnaires were distributed to universities students across China, and valid questionnaires were collected. The Physical Activity Rating Scale (PARS-3), General Self-Efficacy Scale (GSES), Connor-Davidson Resilience Scale (CD-RISC-10), and Career Decision-Making Difficulty Scale (CDMP) were employed.

Comparative mitogenomics reveals evolutionary drivers of Strongyloidea nematodes dwelling in gastrointestinal tract.

Background: The nematode superfamily Strongyloidea represents a prevalent group of gastrointestinal parasites in ruminants and livestock, posing substantial veterinary and economic burdens worldwide. Here we present the first mitochondrial genomic investigation for reconstructing Strongyloidea phylogeny and investigating niche-specific selection dynamics across gastrointestinal habitats (abomasum, small intestine, and large intestine). This study presents a preliminary exploration of the evolutionary adaptations of these agriculturally relevant parasites through comprehensive mitogenomic analysis.

How physical activity enhances academic engagement in middle school: a serial mediation model of interpersonal relationships and academic support.

Introduction: Academic engagement is a critical aspect of adolescent development. Understanding the mechanism of academic engagement will help to take effective measures to improve the academic engagement of middle school students. This study used a serial mediation model to delve into the complex association among physical activity, interpersonal relationships, academic support, and academic engagement in middle school students.

Selective Plasticity of Hippocampal Sub-Regions in the Amnestic Mild Cognitive Impairment After Acupuncture.

Background: Acupuncture has been demonstrated to be effective in reducing cognitive decline in patients with amnestic mild cognitive impairment (aMCI). Hippocampal atrophy has been typically reported as a core neuromechanism in the aMCI. However, whether and how hippocampal subregions plasticity exists in aMCI after acupuncture remains largely unknown.

Effect of acupuncture on episodic memory for amnestic mild cognitive impairment based on hippocampal subregion: study protocol of a randomized, controlled trial.

Background: The hippocampus is a key brain region for episodic memory, and impairment of episodic memory is the earliest feature of amnestic mild cognitive impairment (aMCI). Preserving the structure and function of the hippocampus plays a key role in preventing progression to Alzheimer's disease (AD). Therefore, early intervention is crucial, and acupuncture could significantly improve episodic memory in aMCI, but the mechanism is not clear.

Decoupling fast hydrogen oxidation reaction on a tandem electrocatalyst.

The hydrogen oxidation reaction (HOR) shows fast kinetics in proton exchange membrane fuel cells (PEMFCs), and has not drawn intense attention. Here, we propose a tandem electrocatalysis concept, decoupling HOR on two independent active sites for accelerated kinetics. As a proof-of-concept application, a Ru-based tandem HOR catalyst is designed, with Ru nanoclusters decorated with Pt single atoms.

Mechanism of Polygonatum sibiricum polysaccharide inhibiting oxidation and modifying physicochemical of chicken myofibrillar protein under oxidation system.

This study established a model system consisting of chicken myofibrillar protein (MP) and the Fenton system to investigate the effects of different concentrations of Polygonatum sibiricum polysaccharide (PSP) (0.0 %, 0.1 %, 0.

Inhibited thermal degradation of CsPbBr perovskite quantum dots by dual-Shell engineering towards stable LEDs.

Halide perovskite quantum dots (PeQDs) have garnered significant attention for their exceptional optoelectronic properties, particularly in light-emitting diode (LED) applications. However, their susceptibility to thermal degradation at elevated temperatures (>100 °C) poses a critical barrier to commercialization. In this study, we address this challenge through a synergistic ZnF post-treatment strategy applied to CsPbBr PeQDs.

UvPomt, an O-Methyltransferase Interacting with UvMAT1-1-3, for Regulating Growth, Stress Tolerance, and Virulence in .

Rice false smut (RFS), caused by (teleomorph: ), is a devastating fungal disease that severely impacts global rice production by reducing both yield and grain quality. While the mating-type gene is known to regulate both sexual and asexual reproduction in its regulatory mechanism remains unclear. In this study, an interacting protein of UvMAT1-1-3, a putative O-methyltransferase (UvPomt), was identified using yeast two-hybrid screening, and its interaction was further confirmed by co-localization microscopy.

A new apple polysaccharide for stabilizing goat milk casein dispersion: Rheology, SAXS and intermolecular interaction studies.

In this study, a newly reported apple polysaccharide (AP) capable of forming gels at ambient temperature or even lower with 0.5 % concentration (w/v) was incorporated in 8.0 % goat milk casein (GMC) dispersion for exploring the potential of AP to stabilize the GMC dispersion at a wide pH range (3.

Light-assisted precise control of micro-cavity lasers for lead halide perovskite nanorods.

The development of integrated on-chip lasers featuring both low thresholds and high-quality factors remains a fundamental challenge in photonic integrated circuits, particularly for applications requiring visible coherent light sources. To develop micro-/nanolasers with high robustness and reliability, the fabrication of resonant cavities with controllable morphology and size is essential. In this work, we employed a light-assisted self-assembly approach to direct the formation of CsPbBr quantum dots into uniform, high-quality nanorods (NRs).

Ambient-stable Mg-doped CsCuI nanocrystals with enhanced photoluminescence for color conversion blue LEDs.

We successfully synthesized Mg-doped CsCuI nanocrystals (NCs) under ambient conditions. The 10% Mg-doped CsCuI NCs exhibit significantly enhanced optical properties, achieving a photoluminescence quantum yield (PLQY) of 25.80% and a narrow emission full width at half maximum (FWHM) of 78 nm.

The effects of aerobic exercise in patients with cancer-related fatigue: A systematic review and meta-analysis.

Background: Cancer-related fatigue (CRF) is characterized by an unusual and persistent sensation of tiredness that can occur during or after treatment, potentially impacting both physical and mental capability, and which does not ameliorate with rest. Aerobic exercise (AE) has been identified as a potent modality to mitigate the severity of CRF in such patients.

Objective: This study aims to investigate the efficacy of AE in alleviating CRF among patients.

Targeting TBK1 potentiates oncolytic virotherapy via amplifying ICAM1-mediated NK cell immunity in chemo-resistant colorectal cancer.

Background: Tumor resistance is the primary reason for treatment failure in patients with cancer, while oncolytic viruses (OVs), as a novel therapy, have been rapidly advancing through clinical evaluation and are typically assessed in recurrent tumors that are refractory to standard chemotherapy. However, whether the adaptive process that fosters chemotherapy resistance influences the efficacy of OV therapy is unknown.

Methods: We analyzed chemo-resistant colorectal cancer (CRC) using in vitro, in vivo, and patient-derived organoid models to assess sensitivity to OVs.

Accumulation of GSK-3β in Interneurons Impairs Adult Hippocampal Neurogenesis by Inhibiting GABAergic Transmission.

The activation of glycogen synthase kinase 3β (GSK-3β) and the deterioration of spatial memory represent prominent pathological and clinical manifestations of Alzheimer's disease (AD). Nevertheless, the precise intrinsic mechanisms linking these pathological features remain poorly elucidated. In this study, we identified significant upregulation of GSK-3β activity in inhibitory interneurons within the hippocampal dentate gyrus (DG) of 3×Tg-AD mice.

ARID1A loss enhances sensitivity to c-MET inhibition by dual targeting of GPX4 and iron homeostasis, inducing ferroptosis.

ARID1A, a subunit of the SWI/SNF chromatin-remodeling complex, functions as a tumor suppressor in various cancer types. Owing to its high frequency of inactivating mutations, ARID1A has emerged as a promising target for the development of anticancer drugs. In this study, we report that ARID1A-deficient colorectal cancer (CRC) cells induce synthetic lethality when treated with inhibitors of c-MET receptor tyrosine kinase.

Comprehensive analysis of transcriptome and microbiome in colorectal cancer with synchronous polyp patients.

Background: Colorectal cancer (CRC) is a prevalent and lethal malignancy, with the role of gut microbiota in its development still unclear. This study examines differences in gut microbiota between CRC patients and healthy controls and explores their association with host gene expression to identify potential diagnostic and therapeutic targets.

Methods: Fecal samples from 10 CRC patients and 13 healthy controls were subjected to 16S rRNA sequencing.

Rhizosphere microbes facilitate the break of chlamydospore dormancy and root colonization of rice false smut fungi.

Dormant chlamydospore germination of fungal pathogens directly affects disease occurrence and severity. The rice false smut (RFS) fungus Ustilaginoidea virens produces abundant chlamydospores, but their germination process and roles in plant infection remain unclear. Here, we found that soil-borne chlamydospores are a major source of U.

Suppressed Degradation in Semiconducting Lithium-Rich Oxide Cathode Materials via Phase Structure Engineering.

Owing to anionic oxygen redox (O redox), cathode materials containing lithium-rich oxides (LROs) exhibit a large discharge capacity exceeding 300 mAh·g, in addition to a decent midpoint voltage (∼3.5 V). This makes them viable choices for the fabrication of cathode materials for future development of 500 Wh·kg lithium-ion batteries (LIBs).

Case Report: A case of Felty's syndrome with initial presentation of pleural effusion and subsequent pyothorax.

Background: Pleural effusion is a common disease in respiratory medicine, and rheumatoid arthritis (RA) is one of the causes of pleural effusion. Felty's syndrome is a special manifestation of RA. We report a case of Felty's syndrome with pleural effusion as the initial symptom and the subsequent diagnosis and treatment of the patient's secondary pyothorax.

Mechanism of interaction between key active ingredients and myosin in tea-stewed beef: Improvement of myosin's structural and functional characteristics.

This study analyzed the tea polyphenol components in four types of tea-stewed beef, identifying five key active compounds: epicatechin (EC), epicatechin gallate (ECG), epigallocatechin gallate (EGCG), gallocatechin gallate (GCG), and caffeine (CAF). Oxidative stability, structural changes, and antioxidant activity of complexes formed between these compounds and bovine myosin were assessed. Molecular docking and dynamic simulations were employed to investigate the interaction mechanisms.

Proton perception and activation of a proton-sensing GPCR.

Maintaining pH at cellular, tissular, and systemic levels is essential for human health. Proton-sensing GPCRs regulate physiological and pathological processes by sensing the extracellular acidity. However, the molecular mechanism of proton sensing and activation of these receptors remains elusive.

Associations Between Chronotype, Genetic Susceptibility and Risk of Colorectal Cancer in UK Biobank.

Background: Sleep problems are common in the general population, with evidence suggesting a link between circadian rhythm disruptions and various health outcomes. However, the role of chronotype in influencing colorectal cancer (CRC) risk, particularly in conjunction with genetic predisposition, remains unclear and warrants further investigation.

Methods: We analyzed data from 295,729 UK Biobank participants, among whom 4305 developed colorectal cancer.

Integrative analysis of bulk and single-cell sequencing reveals TNFSF9 as a potential regulator in microsatellite instability stomach adenocarcinoma.

Background: Stomach adenocarcinoma (STAD) with microsatellite instability (MSI) is associated with a better prognosis compared to Non-MSI. This study aims to elucidate the differences in the tumor microenvironment (TME) of MSI and explore its underlying mechanisms in STAD.

Methods: TME differences between MSI and Non-MSI were analyzed using single-cell RNA sequencing (MSI = 7, Non-MSI = 19) and bulk RNA sequencing (MSI = 39, Non-MSI = 198).