Associations Between Chronotype, Genetic Susceptibility and Risk of Colorectal Cancer in UK Biobank.

Background: Sleep problems are common in the general population, with evidence suggesting a link between circadian rhythm disruptions and various health outcomes. However, the role of chronotype in influencing colorectal cancer (CRC) risk, particularly in conjunction with genetic predisposition, remains unclear and warrants further investigation.

Methods: We analyzed data from 295,729 UK Biobank participants, among whom 4305 developed colorectal cancer.