Epigenetic‑ncRNA crosstalk in atherosclerosis: Mechanisms, disease progression and therapeutic potential (Review).

Atherosclerosis is a chronic and progressive vascular disease involving the gradual accumulation of lipids, cholesterol, cellular debris, and fibrous elements within the arterial wall. This process leads to the thickening and hardening of arteries, resulting in restricted blood flow and reduced oxygen delivery to tissues. Over time, these pathological changes significantly elevate the risk of life‑threatening cardiovascular events, including myocardial infarction and ischemic stroke.

Characterizing the relationship between FLAIR hyper-rim lesions and paramagnetic rim lesions in multiple sclerosis.

Paramagnetic rim lesions (PRLs), identified using susceptibility-sensitive sequences, are established prognostic imaging markers for multiple sclerosis (MS). However, susceptibility-sensitive sequences are not yet routinely performed in many clinical centers. We aim to investigate an imaging feature observed on conventional T2 fluid-attenuated inversion recovery (FLAIR) sequences, termed "FLAIR hyper-rim", and explore its association with PRLs.

Use of multiple metrics and clustering analysis to assess antimicrobial use in Shanxi hospitals, China: a cross-sectional study based on 25 general hospitals.

Objective: To investigate the current patterns of antimicrobial use among nonsurgical inpatients across 25 general hospitals in Shanxi Province and to evaluate the antimicrobial use rate, antimicrobial use density (AUD), days of therapy (DOT), length of therapy (LOT), and the application of cluster analysis in monitoring antimicrobial prescribing practices.

Methods: This study included 25 general hospitals covering 11 cities in Shanxi Province. In total, 2064 hospitalized nonsurgical patients were evaluated for antimicrobial use between December 1, 2022, and January 31, 2023.

Genetic and Evolutionary Analysis of Porcine Kobuvirus in Guangxi Province, Southern China, Between 2021 and 2025.

Kobuvirus is a new genus of viruses in the family causing diarrhea in animals. Porcine kobuvirus (PKV) is an important pathogen with a high rate of infection in pig herds. In this study, a total of 10,990 fecal swabs and tissue samples were collected from different areas of Guangxi province in southern China during 2021-2025 and then tested for PKV using RT-qPCR.

Risk factors for pneumonitis after the combination treatment of immune checkpoint inhibitors and thoracic radiotherapy.

Background: The combination of immune checkpoint inhibitors (ICIs) and thoracic radiotherapy (TRT) has played a significant role in the improvement of tumor therapy, but the increased incidence of pneumonitis has greatly limited its application. To identify potential intervention targets, we analyzed risk factors for pneumonitis after combination therapy with ICIs and TRT.

Methods: Overall, 335 patients who received TRT and ICI therapy concurrently or sequentially were included in our study.

Sampled-Data Control for Time-Scale-Type Systems Under Denial-of-Service Attacks.

This article tackles the sampled-data control issue for a class of time-scale-type systems (TSTSs) subject to denial-of-service (DoS) attacks. A novel sampled-data control protocol, that incorporate the backward-jump-like operator (BJLO), is proposed to ensure compatibility with the discontinuity of time scales. Furthermore, a generalized Halanay-like inequality (GHLI) is proposed to address the effects of time scale discontinuities and DoS attacks on sampling intervals.

Subvoxel quantitative susceptibility mapping of chronic white matter lesions: Enhancing lesion heterogeneity characterization and providing complementary biomarkers for myelin integrity in multiple sclerosis.

Objectives: Quantitative susceptibility mapping (QSM) has been used to classify chronic white matter lesions (WMLs) in multiple sclerosis (MS), which exhibit varying myelin and iron content. Compared to QSM, subvoxel-QSM can further differentiate susceptibility alterations arising from demyelination and iron accumulation. This study aims to evaluate the performance of subvoxel-QSM in classifying chronic WMLs in relapsing-remitting MS (RRMS) and explore their heterogeneity.

Benzoylpaeoniflorin alleviates ulcerative colitis by inhibiting ferroptosis through targeting phosphogluconic dehydrogenase.

Background: Ulcerative colitis (UC) is a clinically refractory diseases of the digestive system. Benzoylpaeoniflorin (BP) is a compound from Baishao, a Chinese herbal medicine documented with effects of anti-enteritis. However, the potential of BP in treating UC, along with its underlying mechanisms, requires further elucidation.

Subfunctionalization, neofunctionalization, and nonfunctionalization of the four soybean phytochrome A genes.

Gene duplication generates new genes, which retain their original function or undergo subfunctionalization, neofunctionalization, or nonfunctionalization. The phytochrome A (PHYA) genes in soybean (Glycine max) have undergone duplication to produce GmPHYA1, GmPHYA2 (E4), GmPHYA3 (E3), and GmPHYA4, each with distinct evolutionary fates. Using genetic and biochemical analyses, we discovered that GmPHYA1 has undergone subfunctionalization and is essential for regulating photomorphogenesis and plant height in soybean.

Protamine-Facilitated Same-Day Discharge Following Distal Transradial Angiography.

Background: Despite growing adoption of distal transradial approach (dTRA), data on same-day discharge with protamine-assisted hemostasis following coronary angiography (CAG) remain limited. This pilot study investigated its safety and feasibility.

Methods: From January 2022 to September 2024, a total of 34 patients who were discharged on the same-day after elective CAG via dTRA in our center were included, as well as 34 matched patients who underwent CAG via standard transradial approach (sTRA) during the same period.

Kaempferol Alleviates Carbon Tetrachloride-Induced Liver Fibrosis in Mice by Regulating Intestinal Short-Chain Fatty Acids.

Liver fibrosis remains a critical health concern with limited therapeutic options. Kaempferol (Kae) is a natural flavonoid widely present in natural plants, yet its role in modulating gut-liver axis interactions during fibrosis is unexplored. This study investigates the hepatoprotective effects of Kae on alleviating carbon tetrachloride (CCl)-induced liver fibrosis, and its underlying mechanisms, focusing on oxidative stress, gut microbiota, and short-chain fatty acids (SCFAs), are revealed.

Effect of humic acid on the transport of vanadium oxides nanoparticles in water saturated packed columns.

Abundant vanadium oxides nanoparticles (VOx NPs) release to environment during their production and application. However, little is known on their environmental behaviors, especially under the influence of ubiquitous organic matter (OM). This study investigated the transport of VO, VO, and VO NPs in saturated aquifer in the presence of humic acid (HA), the main dissolved OM in aqueous environment.

Molybdenum etching-treated ultrathin NiFeMo LDHs nanosheet arrays as a performance anodic catalyst for efficient industrial production of hydrogen.

Water-splitting is a critical technology for the conversion and storage of renewable energy. The slow anodic process dynamics with high overpotential greatly limit the commercialization of electrolytic hydrogen production. Herein, we proposed an electrochemical etching method to achieve molybdenum component-controlled dissolution of ultrathin NiFeMo layered double hydroxides (LDHs) nanosheet arrays on nickel-iron foam (NFF) to create reconstructed oxygen evolution reaction (OER) active sites in LDHs.

Manganese MOF-derived ruthenium-doped MnO catalyst for enhanced oxygen evolution reaction and energy-efficient lead recovery.

Advanced, efficient, and eco-friendly technologies are essential for the safe recycling of spent lead-acid batteries for minimizing their environmental impact by mitigating toxic wastes and promoting resource sustainability by recovering valuable lead. Herein, we proposed a simple, zero-emission electrochemical strategy to recover metallic lead the direct electrolysis of lead-acid batteries. MnO@RuO with a layered structure of stacked nanosheets was prepared facile hydrothermal and annealing methods.

Spatiotemporal distribution, co-occurrence patterns, and potential effects of virulence factors in bioaerosols emitted from an Anaerobic-Anoxic-Aerobic wastewater treatment plant.

Bacterial pathogenicity poses a significant concern for both environmental and public health. Various virulence factors (VFs) contribute to the establishment and pathogenicity of bacteria, either independently or in combination. VFs are key indicators of the invasive potential of a pathogen.

Developmental PBDE exposure impairs histamine release from mast cells by altering granule maturation and calcium signaling in adult male and female mice.

Polybrominated diphenyl ethers (PBDEs) are synthetic flame retardants once widely used in furniture, electronics, and other consumer products. Although phased out in the early 2000s, their chemical persistence, recycling into new materials, and leaching from waste sites have led to ongoing environmental contamination and widespread human exposure, especially through diet and indoor dust. This is particularly concerning for developing individuals, who not only accumulate the highest levels via placental transfer, breastfeeding, and behavioral factors, but are also especially vulnerable to long-term effects.

Cantharidin-Loaded Nanomedicine Modified with Amphiphilic Peptides Induce Immunogenic Cell Death to Enhance PD-1 Blockade.

Recent advances in immune checkpoint inhibitors (ICIs), particularly those targeting PD-1/PD-L1, have transformed cancer treatment. However, their efficacy is often hampered by the immunosuppressive tumor microenvironment (TME). Here, we developed a cantharidin-loaded nanomedicine (CA@TPGS-AmP), composed of D-α-tocopheryl polyethylene glycol succinate (TPGS) and naturally derived amphiphilic peptides (AmP), designed to enhance PD-1 blockade via induction of immunogenic cell death (ICD).

Microbiota-dependent metabolites - New engine for T cell warriors.

Microbiota-dependent metabolites (MDMs) are small bioactive molecules produced or modified through microbial metabolic processes, playing an essential role in the communication between prokaryotic and eukaryotic cells. One of their most important roles is their regulatory effects on the immune system, particularly in shaping the development, differentiation, and function of T cells, which are key players in the adaptive immune response. Emerging research highlights those microbial metabolites, such as short-chain fatty acids (SCFAs), tryptophan-derived metabolites, and bile acids (BAs), modulate T cell responses in both health and disease contexts, impacting conditions ranging from autoimmune disorders to cancer.

Plasma proteomic profiling of hospitalized patients co-infected with HIV and SARS-CoV-2.

Background: The interaction between human immunodeficiency virus (HIV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections presents a critical challenge to immunopathogenesis. While HIV infection induces progressive CD4 T cell depletion and chronic immune dysfunction, SARS-CoV-2 triggers complex host responses, ranging from localized antiviral defense to systemic hyperinflammation. We aimed to illustrate the plasma proteomic profiles of hospitalized patients coinfected with HIV and SARS-CoV-2.

Predictive Model for In-Hospital Death in Older Patients with Type 2 Diabetes Mellitus: A Multicenter Retrospective Study in Southwest China.

Objective: Older patients with type 2 diabetes mellitus (T2DM) often face severe health challenges. This study aims to develop and validate a predictive model for estimating in-hospital death risk in this population.

Methods: Clinical data of 17,421 patients with T2DM aged ≥ 65 years admitted to six hospitals in southwest China were collected retrospectively.

Ambient-stable Mg-doped CsCuI nanocrystals with enhanced photoluminescence for color conversion blue LEDs.

We successfully synthesized Mg-doped CsCuI nanocrystals (NCs) under ambient conditions. The 10% Mg-doped CsCuI NCs exhibit significantly enhanced optical properties, achieving a photoluminescence quantum yield (PLQY) of 25.80% and a narrow emission full width at half maximum (FWHM) of 78 nm.