Developmental PBDE exposure impairs histamine release from mast cells by altering granule maturation and calcium signaling in adult male and female mice.

Polybrominated diphenyl ethers (PBDEs) are synthetic flame retardants once widely used in furniture, electronics, and other consumer products. Although phased out in the early 2000s, their chemical persistence, recycling into new materials, and leaching from waste sites have led to ongoing environmental contamination and widespread human exposure, especially through diet and indoor dust. This is particularly concerning for developing individuals, who not only accumulate the highest levels via placental transfer, breastfeeding, and behavioral factors, but are also especially vulnerable to long-term effects.