B blood type indicates poorer overall survival in patients with severe burn injuries: a case-control study.

Introduction: This study focuses on the prognostic impact of ABO blood type in patients with severe burn injuries, particularly following the Kunshan explosion, exploring an under-investigated area of burn injury outcomes.

Method: Data from patients admitted after the Kunshan explosion were analyzed, using chi-square tests and multivariate Cox regression to investigate the relationship between ABO blood type and overall survival (OS). The study utilized various performance metrics, including the receiver operator characteristic curve (ROC), decision curve analysis (DCA) and Kaplan-Meier survival curve, for model assessment, along with a subgroup analysis for associated factors.

Benzoylpaeoniflorin alleviates ulcerative colitis by inhibiting ferroptosis through targeting phosphogluconic dehydrogenase.

Background: Ulcerative colitis (UC) is a clinically refractory diseases of the digestive system. Benzoylpaeoniflorin (BP) is a compound from Baishao, a Chinese herbal medicine documented with effects of anti-enteritis. However, the potential of BP in treating UC, along with its underlying mechanisms, requires further elucidation.

Kaempferol Alleviates Carbon Tetrachloride-Induced Liver Fibrosis in Mice by Regulating Intestinal Short-Chain Fatty Acids.

Liver fibrosis remains a critical health concern with limited therapeutic options. Kaempferol (Kae) is a natural flavonoid widely present in natural plants, yet its role in modulating gut-liver axis interactions during fibrosis is unexplored. This study investigates the hepatoprotective effects of Kae on alleviating carbon tetrachloride (CCl)-induced liver fibrosis, and its underlying mechanisms, focusing on oxidative stress, gut microbiota, and short-chain fatty acids (SCFAs), are revealed.

Luteolin delays the progression of IgA nephropathy by attenuating inflammation, oxidative stress and reducing extracellular matrix accumulation through activating the Nrf-2/HO-1 pathway.

IgA nephropathy (IgAN) is the most common primary glomerulonephritis and the main cause of end-stage renal disease (ESRD). Luteolin (Lut), which is present in various plants, has anti-inflammatory and antioxidant properties under numerous medical conditions. This study aimed to investigate the therapeutic effects and potential mechanisms of Lut on IgAN.

Isolation and characterization of Polaribacter sargassicola sp. nov. and Algibacter ulvanivorans sp. nov.: two novel species with ability to degrade algal polysaccharides.

The genera Polaribacter and Algibacter, which are members of the Bacteroidota family Flavobacteriaceae, are well known for their arsenal of carbohydrate-active enzymes (CAZymes) and specialized polysaccharide utilization loci (PULs). In this study, two aerobic, gram-negative, and rod-shaped bacterial strains, designated strains DS7-9 and PT7-4, were isolated from the surface of seaweed collected from the coastal zone of Fujian Province, China. The two strains exhibited broad tolerance ranges to salinity (0-4%), temperature (10-40 °C) and pH (5.

Assessment of quality of reporting and methodology in systematic reviews of moxibustion for chronic diseases using PRISMA 2020 and AMSTAR 2.

Background: Moxibustion is a simple and low-cost technique for chronic diseases. This study aimed to evaluate the quality of reports and methodologies of systematic reviews (SRs) related to the treatment of chronic diseases with moxibustion.

Methods: Six databases were searched to identify moxibustion SRs for the treatment of chronic diseases.

Anti-β2 glycoprotein domain 1 antibody as a diagnostic marker for antiphospholipid syndrome and a predictor of thrombosis: a systematic review and meta-analysis.

Anti-β2 glycoprotein I domain 1 (anti-β2GPI-D1) antibodies have shown promise as diagnostic and prognostic markers for antiphospholipid syndrome (APS), but their clinical significance remains uncertain. This systematic review and meta-analysis evaluated the diagnostic accuracy of anti-β2GPI-D1 for APS and its association with thrombotic risk. A comprehensive search was conducted across PubMed, Web of Science, and Embase up to July 18, 2024.

Advances in perovskite-based neuromorphic computing devices.

Neuromorphic computing devices, inspired by the architecture and functionality of the human brain, offer a promising solution to the limitations imposed by the von Neumann bottleneck on contemporary computing systems. Perovskite materials are widely used in the photosensitive layer of neuromorphic computing devices due to their high light absorption coefficient and excellent carrier mobility. Here, we summarise the latest research progress on neural morphology computing devices based on perovskite materials with different structures and summarise different application scenarios.

Machine learning prediction model for functional prognosis of acute ischemic stroke based on MRI radiomics of white matter hyperintensities.

Objective: The purpose of the current study is to explore the value of a nomogram that integrates clinical factors and MRI white matter hyperintensities (WMH) radiomics features in predicting the prognosis at 90 days for patients with acute ischemic stroke (AIS).

Methods: A total of 202 inpatients with acute anterior circulation ischemic stroke from the Department of Neurology, Xuzhou Central Hospital between September 2023 and March 2024 were retrospectively enrolled. Inpatient clinical data and cranial MRI images were acquired.

Proper early weaning from ventilator assistance influences the overall survival of patients with severe burns: A case-control study.

Background: Ventilator assistance is crucial in the treatment of severely burned patients. However, there is no consensus on the optimal duration of ventilator assistance, and whether it has an impact on the short - and long-term prognosis of severely burned patients is still unclear.

Methods: We incorporated 185 severely burned patients in our study.

CT based 3D radiomic and clinical airway examination model for evaluating mask ventilation in oral and maxillofacial surgery patients.

The objective of this study is to develop a model that incorporates clinical measurements with 3D radiomic signatures extracted from CT images of oral and maxillofacial surgery patients to evaluate mask ventilation. A prospective cohort trial was conducted to enroll patients scheduled for oral and maxillofacial surgery. After obtaining informed consent, clinical measurements and head and neck CT images were collected.

Optimal Timing and Approaches for First Tangential Excision in Patients with ≥70% TBSA Burns: Insights from a Retrospective Cohort of a Mass Casualty Incident.

Objective: We aim to determine the optimal timing and approaches for first tangential excision of severely burned patients ≥70% total body surface area (TBSA).

Background: Early tangential excision is the gold-standard surgical therapy for full-thickness burns. However, there are debates about its optimal timing and approaches for severely burned patients ≥70%TBSA.

Mixed grafting of small auto- and cryopreserved allo-skin for residual wound repair in severe burn patients: A retrospective study.

Background: The wound repair process for extensively deep burn patients is a recurring and highly challenging endeavor. A prolonged healing time beyond 3 weeks after injury often leads to compromised healing outcomes. The limited availability of autologous skin grafts remains the primary obstacle in achieving timely wound repair.

Novel antibiotics against without detectable resistance by targeting proton motive force and FtsH.

The increased prevalence of methicillin-resistant (MRSA) and its biofilms poses a great threat to human health. Especially, -related osteomyelitis was hardly cured even by conventional antibiotics combined with surgical treatment. The development of novel structural antibiotics is urgently needed.

Machine learning for epithelial ovarian cancer platinum resistance recurrence identification using routine clinical data.

Background: Most epithelial ovarian cancer (EOC) eventually develops recurrence. Identification of high-risk patients can prompt earlier intervention and improve long-term outcomes. We used laboratory and clinical data to create models based on machine learning for EOC platinum resistance recurrence identification.

Suppression of overactivated immunity in the early stage is the key to improve the prognosis in severe burns.

Background: Severe burns can lead to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) due to inflammation-immunity dysregulation. This study aimed to identify key immune-related molecules and potential drugs for immune regulation in severe burn treatment.

Method: Microarray datasets GSE77791 and GSE37069 were analyzed to identify immune-related differentially expressed genes (DEGs), enriched pathways and prognosis-related genes.

Efficacy and safety of moxibustion as a complementary and alternative therapy for asthma: A systematic review and meta-analysis.

Objective: This systematic review of randomized controlled trials (RCTs) aimed to evaluate the efficacy and safety of moxibustion as a complementary or alternative treatment for asthma.

Methods: Seven databases were searched up to June 23, 2024, to identify RCTs assessing moxibustion for bronchial asthma. The outcomes of interest included response to treatment, asthma control, quality of life, lung function, immunological indicators, and incidence of adverse events (AEs).

A 10-year mono-center study on patients with burns ≥70% TBSA: prediction model construction and multicenter validation - retrospective cohort.

Background: Burn injuries with ≥70% total body surface area (TBSA) are especially acute and life-threatening, leading to severe complications and terrible prognosis, while a powerful model for the prediction of overall survival (OS) is lacking. The objective of this study is to identify prognostic factors for the OS of patients with burn injury ≥70% TBSA and construct and validate a feasible predictive model.

Materials And Methods: Patients diagnosed with burns ≥70% TBSA admitted and treated between 2010 and 2020 in our hospital were included.

Mechanism of Mulberry Leaves and Black Sesame in Alleviating Slow Transit Constipation Revealed by Multi-Omics Analysis.

Traditional Chinese medicine (TCM) possesses the potential of providing good curative effects with no side effects for the effective management of slow transit constipation (STC), an intestinal disease characterized by colonic dyskinesia. Mulberry leaves L.) and black sesame ( L.

Lusutrombopag as a Repurposing Drug in Combination with Aminoglycosides against Vancomycin-Resistant Enterococcus.

Due to the widespread abuse of antibiotics, drug resistance in Enterococcus has been increasing. However, the speed of antibiotic discovery cannot keep pace with the acquisition of bacterial resistance. Thus, drug repurposing is a proposed strategy to solve the crises.

Recombinant Human Collagen Type III Improves Hypertrophic Scarring by Regulating the Ratio of Type I/III Collagen.

Hypertrophic scar development is a complication associated with wound healing, impacting local appearance and function. The type I/III collagen ratio affects the extent of hypertrophic scarring; a reduced ratio can ameliorate this. In this study, recombinant human collagen type III was developed.

Subtype recognition and identification of a prognosis model characterized by antibody-dependent cell phagocytosis-related genes in breast cancer.

Background: Breast cancer (BC) is a heterogeneous tumor with a variety of etiology and clinical features. Antibody-dependent cell phagocytosis (ADCP) is the last step of immune checkpoint inhibition (ICI), and macrophages detect and recognize tumor cells, then destroy and engulf tumor cells. Despite the large number, negative regulators that inhibit phagocytic activity are still a key obstacle to the full efficacy of ICI.