Polarization-Sensitive Photodetector Based on WSe/AsP/WS Heterojunction.

The rapid advancements in optoelectronics and their widespread applications have spurred the development of high-performance photodetectors. This study presents a dual-van der Waals heterostructure photodetector, composed of WSe, AsP, and WS. It demonstrates outstanding polarization-sensitive light detection without external bias, with a sensitivity of 487 mA/W, a detection capability of 6.

Ultrasound-Activated BiOI/TiC Heterojunctions in 3D-Printed Piezocatalytic Antibacterial Scaffolds for Infected Bone Defects.

Piezocatalytic therapy (PCT) is a promising strategy for combating implant-associated infections due to its high tissue penetration depth and non-invasive nature. However, its catalytic efficiency remains limited by inefficient electron-hole separation. In this work, an ultrasound-responsive heterojunction (BiOI/TiC) was fabricated through in situ growth of bismuth iodide oxide on titanium carbide nanosheets.

Swept-Source Optical Coherence Tomography Angiography for Retinal Neurovascular Structural Evaluation in a Chronic Unpredictable Mild Stress Rat Model.

Purpose: The purpose of this study was to evaluate the retinal thickness and vascular changes in a chronic unpredictable mild stress (CUMS) rat model using swept-source optical coherence tomography angiography (SS-OCTA).

Methods: Eight-week-old male Sprague Dawley rat models of CUMS (n = 11) and age-matched control rats (n = 12) were imaged by a customized SS-OCTA system. Two groups were imaged after modeling stimulation for 12 weeks.

Effects of two typical organophosphate flame retardants on DNA damage of GT1-7 cells and relevant molecular mechanism.

The tris (2-chloroethyl) phosphate (TCEP) and tri-n-butyl phosphate (TNBP) are two typical organophosphate esters (OPEs), which have estrogenic activity. However, fewer studies have been conducted on their genotoxicity and mechanisms. In this study, we evaluated the effects of TCEP and TNBP on cellular DNA damage in GT1-7 cells and examined the role of estrogen signaling in regulating DNA damage.

Cost-Effective Inorganic Multilayer Film for High-Performance Daytime Radiative Cooling.

Inorganic multilayer films for radiative cooling have garnered significant attention due to their exceptional resistance to photothermal degradation. However, the design and fabrication of structurally simple and cost-effective inorganic multilayer films remain challenging due to limitations in material properties and the preparation process. This study develops a structurally simple inorganic multilayer film (SiN/SiO/AlO/SiN/Al) for daytime radiative cooling.

Effectiveness of Microwave Therapy Combined with Berberine /GelMA via COX-2/IL-1β Pathway to Treat Skeletal Muscle Injury: An in vivo Study in Rats.

Introduction: Skeletal muscle injuries are short-term, that occur in people who play sports and train. Regular exercise and sports populations undergo repetitive tearing and regeneration of skeletal muscle, in which muscle damage is a necessary component to produce an oxidative inflammatory response and tissue reconstruction. The primary goals of treating this illness are to reduce the disease process cycle and get rid of symptoms like swelling and inflammation at the site of localized injury.

Cloning and Expression of the Isoprocarb Hydrolase Gene cehA from the Newly Isolated Isoprocarb-Degrading Strain Sphingobium sp. R-7.

To remove the isoprocarb residues from the environment, a bacterial strain that was capable of degrading isoprocarb was isolated from agricultural soils where isoprocarb has been applied for a long period, and named R-7. On the basis of its cellular morphology and phenotypic features and 16S rRNA phylogenetic analysis, strain R-7 was preliminarily identified as Sphingobium sp. This strain could grow on isoprocarb as a sole carbon source and degrade 98.

Evaluation of Auricular Acupressure on Myopia Prevention among Children Aged 6-12 Years with Pre-Myopia in China: Study Protocol of a Prospective Multi-Center Randomized Controlled Trial.

Background: The increasing prevalence of myopia among Chinese children and adolescents, especially at younger ages, has emerged as a significant concern in recent years. Pre-myopia is a key period for myopia prevention and control in children and adolescents. Previous studies suggested auricular acupressure (AA) therapy might offer a viable approach to prevent and slow down myopia progression.

Green carbon dots derived from alleviate ovalbumin-induced allergic rhinitis.

Background: Allergic rhinitis (AR) affects up to 40% of the population, leading to significant healthcare expenditures. Current mainstream treatments, while effective, can lead to side effects and do not address the underlying immunological imbalances. (ZRC), the partially charred product of (ZR), has been widely used clinically in China since ancient times to treat respiratory disorders.

Acupuncture Combined with Periocular Injection for Treatment of Hydroxychloroquine Retinopathy with Cystoid Macular Edema: A Case Report.

For HCQ retinopathy with CME, acupuncture combined with periocular injection can be used to improve the CME and protect the central vision. Subsequent research endeavors involving a more extensive cohort and extended observation periods are warranted to evaluate the effectiveness and safety profile of the intervention.

Parental awareness on myopia prevention and control among 350 children.

Aim: To understand the current situation of parental perspectives, knowledge, and practices concerning myopia prevention and control for both pre- and school-aged children.

Methods: This study was a cross-sectional survey that involved children aged 0 to 15y and their parents. Participants were required to respond to an online questionnaire by scanning a quick response (QR) code.

Gastrointestinal stromal tumors regulate macrophage M2 polarization through the MIF/CXCR4 axis to immune escape.

Purpose: The infiltration of immune cells and their roles of the infiltrating-immune cells in gastrointestinal stromal tumor (GIST) is still unclear. We aimed to discover the infiltration cell types and the relationship between the infiltrating-immune cells and the progression of GIST.

Experimental Design: Single-cell RNA sequencing were performed to discover types of the infiltrating-immune cells and to analyze CellChat between cells.

Multi-Source Information-Based Bearing Fault Diagnosis Using Multi-Branch Selective Fusion Deep Residual Network.

Rolling bearing is the core component of industrial machines, but it is difficult for common single signal source-based fault diagnosis methods to ensure reliable results since sensor signals are vulnerable to the pollution of background noises and the attenuation of transmitted information. Recently, multi-source information-based fault diagnosis methods have become popular, but the information redundancy between multiple signals is a tough problem that will negatively impact the representational capacity of deep learning algorithms and the precision of fault diagnosis methods. Besides that, the characteristics of various signals are actually different, but this problem was usually omitted by researchers, and it has potential to further improve the diagnosing performance by adaptively adjusting the feature extraction process for every input signal source.

Natural medicines-derived carbon dots as novel oral antioxidant administration strategy for ulcerative colitis therapy.

Background: Ulcerative colitis (UC) is a chronic intestinal inflammation, resulting in a global healthcare challenge with no real specific medicine. Natural medicines are recognized as a potential clinical alternative therapy, but their applications are limited by poor solubility and low bioavailability.

Results: In this work, inspired by the natural medicines of ancient China, novel functional carbon dots derived from Magnetite and Medicated Leaven (MML-CDs) were synthesized by hydrothermal method, and confirmed their ultrasmall nano-size (3.

M2 macrophage-derived extracellular vesicles ameliorate Benzalkonium Chloride-induced dry eye.

Dry eye disease (DED) is a common ocular condition affecting a significant portion of the global population, yet effective treatment options remain elusive. This study investigates the therapeutic potential of M2 macrophage-derived extracellular vesicles (M2-EVs) in a mouse model of DED. The DED model was established using 0.

Short-term exposure to indoor artificial light at night during sleep impairs cardiac autonomic function of young healthy adults in China.

The artificial light at night (ALAN) exposure has emerged as a significant environmental and public health concern globally. However, there is far less evidence on the health effects of indoor ALAN than on outdoor ALAN. Moreover, evidence on cardiovascular effects of indoor ALAN is more limited.

G-Protein Coupled Receptor 1 Is Involved in Tetrachlorobisphenol A-Induced Inflammatory Response in Jurkat Cells.

Estrogens can affect the immune inflammatory response through estrogen receptor alpha (ERα), but the specific role of estrogen member receptor G-protein coupled receptor 1 (GPER1) in this process remains unclear. In this study, we evaluated the effects of tetrachlorobisphenol A (TCBPA), which has estrogen activity, on immune inflammatory-related indicators of Jurkat cells, as well as investigated the role of GPER1 in these effects. The results showed that TCBPA at lower concentrations significantly promoted the viability of Jurkat cells, whereas higher concentrations decreased cell viability.

Pseudomyopia treated with auricular point sticking combined with periocular needle-embedding therapy and prevention of true myopia: a multicenter randomized controlled trial.

Objectives: To observe the clinical effect and safety of auricular point sticking combined with periocular needle-embedding therapy for pseudomyopia and prevention of true myopia.

Methods: A total of 269 children with pseudomyopia were randomized into an observation group (134 cases, 2 cases dropped out) and a control group (135 cases, 5 cases dropped out). In the control group, the healthy education was provided.

Multifunctional coatings of nickel-titanium implant toward promote osseointegration after operation of bone tumor and clinical application: a review.

Metal implants, especially Ni-Ti shape memory alloy (Ni-Ti SMA) implants, have increasingly become the first choice for fracture and massive bone defects after orthopedic bone tumor surgery. In this paper, the internal composition and shape memory properties of Ni-Ti shape memory alloy were studied. In addition, the effects of porous Ni-Ti SMA on osseointegration, and the effects of surface hydrophobicity and hydrophilicity on the osseointegration of Ni-Ti implants were also investigated.

In Vitro Profiling of Toxicity Effects of Different Environmental Factors on Skin Cells.

The skin is constantly exposed to a variety of environmental threats. Therefore, the influence of environmental factors on skin damage has always been a matter of concern. This study aimed to investigate the cytotoxic effects of different environmental factors, including cooking oil fumes (COFs), haze (PM), and cigarette smoke (CS), on epidermal HaCaT cells and dermal fibroblast (FB) cells.

Experimental study on new structure teeth in a high-temperature environment.

In high-temperature drilling, especially in high-temperature geothermal drilling, cone bits often experience common and severe tooth loss. This issue significantly reduces the cone bit's service life and has a detrimental impact on drilling efficiency. The quality of the fixed teeth plays a crucial role in the performance of the cone bit.

Smart nanogels for cancer treatment from the perspective of functional groups.

Cancer remains a significant health challenge, with chemotherapy being a critical treatment modality. However, traditional chemotherapy faces limitations due to non-specificity and toxicity. Nanogels, as advanced drug carriers, offer potential for targeted and controlled drug release, improving therapeutic efficacy and reducing side effects.

Available and novel plant-based carbon dots derived from Vaccaria Semen carbonisata alleviates liver fibrosis.

Liver fibrosis represents an intermediate stage in the progression of liver disease, and as of now, there exists no established clinical therapy for effective antifibrotic treatment. Our aim is to explore the impact of Carbon dots derived from Carbonisata (VSC-CDs) on carbon tetrachloride-induced liver fibrosis in mice. VSC-CDs were synthesized employing a modified pyrolysis process.

Effects of trichlorobisphenol A on the expression of proteins and genes associated with puberty initiation in GT1-7 cells and the relevant molecular mechanism.

This study evaluated the effects of ClBPA on kisspeptin-G-protein coupled receptor 54 (GPR54)/gonadotropin-releasing hormone (GnRH) (KGG) signals and analyzed the roles of estrogen receptor alpha (ERɑ) and G-protein coupled estrogen receptor 1 (GPER1) in regulating KGG signals. The results showed that ClBPA at 50 μM increased the levels of intracellular reactive oxygen species (ROS) and GnRH, upregulated the protein levels of kisspeptin and the expression of fshr, lhr and gnrh1 genes related to KGG in GT1-7 cells. In addition, 50 μM ClBPA significantly upregulated the phosphorylation of extracellular regulated protein kinases 1/2 (Erk1/2), the protein levels of GPER1 and the expression of the gper1 as well as the most target genes associated with mitogen-activated protein kinase (MAPK)/Erk1/2 pathways.