(Polygonaceae: Persicarieae), a Distinct New Species From Xizang, Southwestern China.

, a distinctive new species discovered in Medog County, southeastern Xizang, China, is here described and illustrated. The generic placement of this species was validated through integrated morphological and palynological observations, as well as molecular phylogenetic analyses using three cpDNA markers (, , and ). Within , is most closely related to but differs significantly in growth habit, leaf shape, inflorescence structure, and achene micromorphology.

Activation of the TLR2/NF-κB signaling axis by capsid proteinVP1 of feline calicivirus promotes IL-1β expression in vitro.

Feline calicivirus (FCV) induces systemic inflammation in felines, posing a serious threat to feline health worldwide. Severe cases may lead to chronic stomatitis and other inflammatory conditions. However, the precise mechanisms underlying FCV-induced inflammation remain unclear.

Mitigating emissions and costs through demand-side solutions in Chinese residential buildings.

The building sector plays a pivotal role in climate change mitigation. By regulating the demand for services and products from supply sectors, building sector can contribute to decarbonization. To assess the decarbonization and cost-saving potential of demand-side solutions for China's residential building sector, this study develops a demand-side solution framework and an end-use technology model.

Lithium price uncertainties due to the development of battery technology under carbon neutrality target.

Driven by carbon neutrality target, a faster low-carbon transition will be required in the sectors of electricity and transportation. As a major support for the transition of these sectors, the diffusion of battery technologies in energy storage and electric vehicles will be accelerated. The battery technologies development relies on the price stability of critical materials (nickel, cobalt, lithium), but the price fluctuations caused by potential supply-demand imbalances would become a bottleneck constraining the low-carbon transition and hindering the sustainable application of low-carbon technologies, especially in regions like China where rapid demand expansion intensifies the need for critical material resources (e.

Noninvasive real-time monitoring of cellular spatiotemporal dynamics via machine learning-enhanced electrical impedance spectroscopy.

Monitoring cellular spatiotemporal dynamics is essential for understanding complex biological processes such as organ development and cancer progression. Using live-cell fluorescence microscopy to track cellular dynamics is often limited by dye-induced cytotoxicity and cellular photodamage. Here, we demonstrate an alternative methodology combining microelectrode arrays, electrical impedance spectroscopy (EIS), and machine learning (ML) that enables real-time monitoring of cellular spatiotemporal dynamics in a noninvasive and label-free manner.

A deep learning model for early diagnosis of alzheimer's disease combined with 3D CNN and video Swin transformer.

Alzheimer's disease (AD) constitutes a neurodegenerative disorder predominantly observed in the geriatric population. If AD can be diagnosed early, both in terms of prevention and treatment, it is very beneficial to patients. Therefore, our team proposed a novel deep learning model named 3D-CNN-VSwinFormer.

FCV activates NLRP3 inflammasome through ion-dependent pathway to promote IL-1β secretion.

Feline calicivirus (FCV) poses a significant threat to the health of susceptible animals in the global epidemic. The inflammasome plays a crucial role in the inflammatory process induced by pathogens, functioning in resisting their invasion, responding to cellular damage, and maintaining internal environmental homeostasis.FCV infection in cats causes inflammation,and the regulatory mecha-nisms of the NLRP3 inflammasome on inflammatory factors in infected cells urgently require further investigation.

Pre-mRNA Splicing Functions in Plant Sexual Reproduction Development.

Precursor messenger RNA (pre-mRNA) splicing is a critical post-transcriptional regulatory mechanism in gene expression. The precise splicing of pre-mRNAs is essential for plant development and responding to genetic and environmental signals. In plant sexual reproduction, gene expression regulation relies on the accurate processing of pre-mRNAs, which is fundamental for coordinating developmental programs.

Individually Modified Microneedle Array for Minimal Invasive Multi-Electrolyte Monitoring.

Electrolytes play crucial roles in regulating nerve and muscle functions. Currently, microneedle technology enables real-time electrolyte monitoring through minimally invasive methods. However, due to the small size of microneedles, performing multi-layer modifications on individual microneedles and ensuring the integrity of these layers pose significant challenges.

FoxO4 reduces the damage and mechanism of PEDV-infected IPEC-J2 cells through the NF-κB/MLCK pathway.

Porcine epidemic diarrhea (PED) incurs substantial economic losses to the pig industry. During viral infection of cells, the activity of NF-κB is upregulated. As an endogenous inhibitor, FoxO4 plays a crucial role in antagonizing NF-κB activity, inhibiting the NF-κB-mediated MLCK signaling pathway, altering the expression of cellular tight junctions (TJs) and pro-inflammatory cytokines, and protecting intestinal epithelial cells from damage.

Industry chain risks for the diffusion of low-carbon technologies in the cement industry.

Low-carbon technologies are essential to help the cement industry move towards a low-carbon future. However, the upstream and downstream industries in the industrial chain will be directly affected by the large-scale adoption of these technologies in terms of capital, labor demand and pollutant emissions. Therefore, there is an urgent need to evaluate in advance the risk of imbalance between supply and demand in order to avoid threatening the security of the industrial chain and hindering the low-carbon transition of the cement industry.

Applying deep learning algorithms for non-invasive estimation of carotenoid content in the foot muscle of Pacific abalone with different colors.

Carotenoids are vital pigments influencing both the coloration and health of aquatic organisms, particularly in species such as the Pacific abalone (Haliotis discus hannai). In this study, we identified the major carotenoids in abalone foot muscle using targeted metabolomics. Through differential metabolite analysis, we selected metabolites that met the following criteria: p-value <0.

 (Polygonaceae, Persicarieae), an overlooked new species from Dabie Mountains, central China.

Bo Li, a remarkable new species discovered from the summit of Tiantangzhai Peak of Dabie Mountains in Hubei Province, central China, is described and illustrated. Based on its spicate inflorescences, ciliate ocreae, and the absence of prickles, the species is placed in P.sect.

A novel hybrid biosensor for miRNA detection based on peptide nucleic acids and molecularly imprinted polymers.

The detection of miRNAs serving as key biomarkers in cancer diagnostics is challenging due to their small size, low abundance, and high sequence similarity, which complicates their sensitive and selective detection. Here, we report a biosensor that combines molecularly imprinted polymers (MIPs) with peptide nucleic acids (PNAs) to achieve a sensitive and highly selective miRNA detection in RNA isolates of cancer cells. MIPs were synthesized by electropolymerization utilizing PNA-supported and pre-oriented miR-21 templates molecules, which serve as both a linker for improved template orientation and an assistive recognition element for miRNA binding.

Cas12a is competitive for gene editing in the malaria parasites.

Malaria, caused by the Plasmodium parasites, has always been one of the worst infectious diseases that threaten human health, making it necessary for us to study the genetic function and physiological mechanisms of Plasmodium parasites from the molecular level to find more effective ways of addressing the increasingly pressing threat. The CRISPR (Clustered regularly interspaced short palindromic repeats)-Cas (CRISPR-associated protein) is an RNA-guided adaptive immune system, which has been extensively developed and used as a genome editing tool in many organisms, including Plasmodium parasites. However, due to the physiological characteristics and special genomic characteristics of Plasmodium parasites, most of the tools currently used for genome editing of Plasmodium parasites have not met expectations.

Single-Site Catalyst for the Synthesis of Disentangled Ultra-High-Molecular-Weight Polyethylene.

Disentangled ultra-high-molecular-weight polyethylene (-UHMWPE) solves the problem of the difficult processing of traditional UHMWPE caused by entanglements between molecular chains. In this review, we look into the innovative realm of nascent disentangled UHMWPE, concentrating on the recent advances achieved through the in situ polymerization of ethylene by single-site catalysts. The effect of single-site catalysts and polymerization conditions on the molecular characteristics is discussed in detail from the perspective of mechanism and DFT calculations.

miRNA-328-3p regulates ZO-1 expression and inhibits PEDV proliferation via the PLC-β1-PKC pathway.

Porcine epidemic diarrhea virus (PEDV) is a significant pathogen affecting swine, causing severe economic losses worldwide. This study explores the regulatory role of miRNA-328-3p to ZO-1 expression and its impact on PEDV proliferation via the PLC-β1-PKC pathway in IPEC-J2 cells. We found that miRNA-328-3p can target ZO-1, influencing its expression and subsequently affecting the integrity of tight junctions in the cells.

Effectiveness and Safety of Shengmai San for Viral Myocarditis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Shengmai San (SMS) is a traditional Chinese medicine formula used for supplementing and and can mitigate symptoms related to malignant arrhythmia and heart failure. This systematic review aimed at exploring the effectiveness and safety of SMS for viral myocarditis (VMC). Eight databases from their inception to June 2023 were searched to identified randomized controlled trials (RCTs) focusing on SMS for VMC.

Porcine Epidemic Diarrhea Virus Infection of Porcine Intestinal Epithelial Cells Causes Mitochondrial DNA Release and the Activation of the NLRP3 Inflammasome to Mediate Interleukin-1β Secretion.

Porcine epidemic diarrhea virus (PEDV) induces enteritis and diarrhea in piglets. Mitochondrial DNA (mtDNA) contributes to virus-induced inflammatory responses; however, the involvement of inflammasomes in PEDV infection responses remains unclear. We investigated the mechanism underlying inflammasome-mediated interleukin (IL)-1β secretion during the PEDV infection of porcine intestinal epithelial (IPEC-J2) cells.

Promoting Hydrogen Transfer in Electrochemical CO Reduction via a Hydrogen on Demand Pathway.

The proceeding of electrochemical CO reduction reaction (CORR) requires the formation of active hydrogen species for CO protonation, while traditional catalysts fail to balance the rate of hydrogen supply and CO protonation. Herein, we propose a "hydrogen on demand" mechanism, in which the polarity of the adsorbed CO is enhanced to allow the capture of hydrogen from water without forming free hydrogen species, realizing the matching rate of hydrogen supply and CO protonation. As a proof of concept, we construct Zn-N sites modified by Se atoms, allowing the proceeding of CORR under the "hydrogen on demand" mechanism with superior efficiency.

Research Progress and Application of Layered Rare Earth Hydroxides, a Class of Inorganic Layered Compounds with Photoluminescence.

Inorganic layered compounds are an important part of organic-inorganic functional nanocomposites and offer plentiful opportunities and possibilities for synthesizing new-style multifunctional materials because they could be intercalated, exfoliated, and swollen. In recent years, as inorganic layered materials with photoluminescence, layered rare earth hydroxides (LRHs) have been extensively studied. Due to their rich functionalization ways, they have been applied or shown potential application value in many fields such as pollution detection, biomedicine, photoelectric energy storage, and so on.

Modeling the dynamic impacts of maritime network blockage on global supply chains.

Recent phenomena such as pandemics, geopolitical tensions, and climate change-induced extreme weather events have caused transportation network interruptions, revealing vulnerabilities in the global supply chain. A salient example is the March 2021 Suez Canal blockage, which delayed 432 vessels carrying cargo valued at $92.7 billion, triggering widespread supply chain disruptions.

Ammonium Tetrakis(pentafluorophenyl)borate: Preparation and Application in Olefin Coordination Polymerization as the Cocatalyst Compound.

Metallocene catalysts have attracted much attention from academia and industry for their excellent catalytic activity in the field of olefin polymerization. Cocatalysts play a key role in metallocene catalytic systems, which can not only affect the overall catalytic activity, but also have an obvious influence on the structure and properties of the polymer. Although methylaluminoxane (MAO) is currently the most widely used cocatalyst, its price increases the production cost of polyolefin materials.

Optimum investment strategy for hydrogen-based steelmaking project coupled with multiple uncertainties.

The large-scale application of hydrogen steelmaking technology is expected to substantially accelerate the decarbonization process of the iron and steel industry. However, hydrogen steelmaking projects are still in the experimental or demonstration stage, and scientific investment decision-making methods are urgently needed to support the large-scale development of the technology. When assessing the investment value, existing studies usually only consider the intrinsic project value under a specific pathway, while ignoring the option value under realistic multiple uncertainties in terms of technology, market, and policy, leading to an underestimation of the investment value.