Mixed metal metal-organic framework synergized with functional liposomes boosts bipolar-driven organic photoelectrochemical transistor for highly sensitive biodetection.

Organic photoelectrochemical transistor (OPECT) has emerged as a promising platform for investigating photoactive biomolecular interactions and advancing bioanalytical detection systems. However, many important challenges and hurdles remain implementing high gating effects and sensitive biosensing detection caused by the inherent limitations of the configuration of the photoelectrode structures and innovative biosensing. Inspired by the self-powered photoelectrochemical (PEC) systems and liposomes-assisted bioanalysis for signal amplification, a bipolar-driven poly(3,4-ethylenedioxythiophene): poly(styrene sulfonate) (PEDOT:PSS) OPECT based on CdS/Mixed Metal Metal-Organic Framework (MM-MOF) photoanode and a poly(1,4-diethynylbenzene) (pDEB) cathode is proposed, and exhibits a considerable current gain of ca.

DNA methylation in chronic kidney disease.

Chronic kidney disease (CKD) is a condition that affects people on a global scale. After various stages of progression, CKD is finally characterized by renal fibrosis. As the most pervasive and well-studied epigenetic modification, DNA methylation has recently been associated with the development of renal fibrosis.

Glycosylation of whey protein-gallic acid conjugates with pectin: Improved emulsifying property and interfacial behavior.

This work aimed to determine the effect of glycosylation on the emulsifying property and interfacial behaviors of whey protein (WP) - gallic acid (GA) conjugates. By grafting pectin (PC) with WP-GA conjugates via a glycosylation reaction, WP-GA-PC ternary covalent conjugates were synthesized. The degree of grafting increased significantly with the increase of PC concentration and reached 22.

Quercetin Alleviates Folic Acid-Induced Renal Fibrosis by Inhibiting Tubular Epithelial Cell Ferroptosis via EGFR/ACSL4 Pathway.

Ferroptosis has emerged as a critical contributor to the pathogenesis of chronic kidney disease (CKD). Quercetin, a promising therapeutic agent and flavonoid with potential antiferroptotic properties, has demonstrated renoprotective effects. However, its molecular mechanisms remain unclear.

Evaluating Dental Pain in Diverse Conditions: Findings From Short-Form McGill Pain Questionnaire Study.

Introduction And Aims: Making precise diagnoses of patients with dental pain is challenging. Thus, a screening system that can help accurately stratify patients depending on the severity of their condition is required. In this study, we compared the characteristics of dental pain in patients with different conditions using a Short-Form McGill Pain Questionnaire (SF-MPQ).

FCV activates NLRP3 inflammasome through ion-dependent pathway to promote IL-1β secretion.

Feline calicivirus (FCV) poses a significant threat to the health of susceptible animals in the global epidemic. The inflammasome plays a crucial role in the inflammatory process induced by pathogens, functioning in resisting their invasion, responding to cellular damage, and maintaining internal environmental homeostasis.FCV infection in cats causes inflammation,and the regulatory mecha-nisms of the NLRP3 inflammasome on inflammatory factors in infected cells urgently require further investigation.

Integrated Network Toxicology and Experimental Validation Reveal the Mechanism of Bisphenol A-Induced Kidney Injury: Targeting Macrophage Esr1 Expression and Apoptosis.

Bisphenol A (BPA), an endocrine-disrupting chemical ubiquitously present in environmental matrices, has emerged as a critical public health concern due to its potential multiorgan toxicity. Although epidemiological and experimental evidence associates BPA exposure with diverse pathologies including metabolic syndrome, carcinogenesis, and hepatorenal dysfunction, the molecular pathogenesis underlying BPA-induced nephrotoxicity remains poorly characterized. To systematically elucidate these mechanisms, we employed an integrative network toxicology approach interrogating multiple pharmacological databases (ChEMBL, STITCH) and disease repositories (GeneCards, OMIM) to identify putative molecular targets.

Efficacy and safety evaluation of pulsed laser-activated injectable hydrogel for combined photodynamic and photothermal therapy in hypertrophic scar treatment.

Objective: To explore the efficacy and safety of pulsed laser-activated injectable hydrogel for combined photodynamic and photothermal therapy of hypertrophic scars.

Methods: In this prospective study, indocyanine green (ICG) was used as a photosensitizer combined with hyaluronic acid (HA) to prepare ICG-HA hydrogel, and its photodynamic and photothermal properties were evaluated. The ex vivo photothermal experiments were conducted to assess the thermal effects on tissue integrity as a preliminary evaluation of safety.

Emulsions and oleogels stabilized by egg white protein-tannic acid-xanthan gum conjugate: Preparation, characterization and potential application in curcumin.

In this study, the egg white protein (EWP)-tannic acid (TA)-xanthan gum (XG) ternary conjugate was used to construct emulsion and oleogel delivery systems to load curcumin. The effect of EWP-TA-XG conjugate concentration on the properties of emulsions and oleogels as well as the digestion characteristics of curcumin-loaded emulsion and oleogel were investigated. It was found that with the increase of EWP-TA-XG conjugate concentration, the D[4, 3] of emulsions decreased, while the absolute value of zeta potential and the stability of the emulsions increased.

Hereditary leptomeningeal transthyretin amyloidosis with heterozygous TTR mutation: a case report and literature review.

Objective: This study aimed to characterize the clinical and neuroimaging features of hereditary leptomeningeal transthyretin amyloidosis (hATTR-LA), a dominant inheritance disorder caused by a heterozygous TTR gene mutation.

Methods: A comprehensive retrospective evaluation was conducted, incorporating detailed clinical records, multimodal neuroimaging findings, and a systematic review of the literature to contextualize the observations.

Results: The patient was a 55-year-old male who presented with chronic central nervous system symptoms, including sensory-motor peripheral neuropathy and progressive visual impairment.

Targeting Melatonin to Mitochondria Mitigates Castration-Resistant Prostate Cancer by Inducing Pyroptosis.

Prostate cancer frequently progresses to castration-resistant prostate cancer (CRPC) following androgen deprivation therapy, presenting a significant clinical challenge. Targeting tumor metabolism, particularly mitochondrial pathways, offers a promising strategy for overcoming CRPC. The modification of melatonin (Mel) to a triphenylphosphonium (TPP) cation-targeted mitochondria-melatonin (Mito-Mel) significantly increases its potency by over 1000-fold.

Deep learning-based recognition model of football player's technical action behavior using PCA-LBP algorithm.

Football is a sport that requires sportsmen to have both physical strength and physical features. It must consider the distinctions between individuals and then provide targeted training. Football players can perform better on the field with targeted scientific training, but scientific training is based on identifying football players' technical actions and behaviors.

A combination of microwave treatment and covalent binding of gallic acid improves the solubility, emulsification and thermal stability of peanut protein isolate.

This work aimed to investigate the effect of a combination of microwave treatment and covalent binding of gallic acid (GA) on the structural and functional properties of peanut protein isolate (PPI). It was found that PPI exhibited the maximum solubility at microwave power of 480 W, 60 °C for 4 min. The microwave-treated peanut protein isolates (MPPI) had more binding sites than PPI.

Giant low-grade myofibroblastic sarcoma of the male breast: case report and literature review.

Low-grade myofibroblastic sarcoma is an uncommon malignancy that can be difficult to identify and for which there is no unified treatment protocol. We report herein a case of an 81-year-old male who presented with a giant irregular breast mass and was diagnosed with low-grade myofibroblastic sarcoma. In this study we summarise the clinicopathological features of 13 reported cases of myofibroblastic sarcoma arising in the breast, present the diagnostic process and treatment procedure of our case, and discuss the differential diagnosis from other similar diseases, to provide constructive information and promote deep understanding of myofibroblastic sarcoma in the future.

Quality Markers of Fufang Shenqi Oral Liquid Based on Integrated Fingerprint Analysis, Chemical Pattern Recognition, and Quantification.

Introduction: Fufang Shenqi Oral Liquid (FFSQOL) is an important Chinese medicine compound preparation with a wide range of clinical applications, which is mainly used to regulate immune function, improve cardiovascular function, and have anti-inflammatory and antibacterial effects. At present, it is of great importance to establish the quality evaluation method of FFSQOL and to investigate its quality markers (Q-markers).

Objectives: The aim of this study is to establish a quality evaluation method for FFSQOL and screen its Q-markers to provide a scientific basis for its quality control.

Hydrogen sulfide donor NaHS inhibits formaldehyde-induced epithelial-mesenchymal transition in human lung epithelial cells via activating TGF-β1/Smad2/3 and MAPKs signaling pathways.

Formaldehyde (FA) long term exposure leads to abnormal pulmonary function and small airway obstruction of the patients. Hydrogen sulfide (HS) is one of the recognized gaseous transmitters involved in a wide range of cellular functions. It is unknown the involvement of HS in FA-induced lung injury.

Assessing the performance of large language models (LLMs) in answering medical questions regarding breast cancer in the Chinese context.

Purpose: Large language models (LLMs) are deep learning models designed to comprehend and generate meaningful responses, which have gained public attention in recent years. The purpose of this study is to evaluate and compare the performance of LLMs in answering questions regarding breast cancer in the Chinese context.

Material And Methods: ChatGPT, ERNIE Bot, and ChatGLM were chosen to answer 60 questions related to breast cancer posed by two oncologists.

The impact of discharge readiness on post-traumatic growth in patients after thyroid cancer surgery: the mediating role of sickness-related stigma.

Objective: To investigate the relationship between post-traumatic growth, morbidity stigma and readiness for discharge in post-operative thyroid cancer patients.

Methods: 422 post-operative thyroid cancer patients from three tertiary care hospitals in Hunan and Tianjin were surveyed using the General Information Questionnaire, the Post-traumatic Growth Scale, the Readiness for Discharge Scale, and the Social Influence Scale.

Results: Discharge readiness positively predicted the level of post-traumatic growth in thyroid cancer patients (P < 0.

Clinical utility of metagenomic next-generation sequencing on bronchoalveolar lavage fluid in diagnosis of lower respiratory tract infections.

Background: In this study, we aimed to evaluate the clinical utility of Metagenomic Next-Generation sequencing (mNGS) on bronchoalveolar lavage fluid (BALF) in diagnosis of Lower Respiratory Tract Infections (LRTIs).

Methods: In this study, we retrospectively analyzed 186 hospitalized patients who were suspected with LRTIs and performed mNGS (DNA) test of BALF simultaneously at The Fifth Affiliated Hospital of Sun Yat-Sen University from March 2023 to August 2023. Suspected LRTI was based on LRTI related clinical manifestations or imaging examination.

MiR-331-3p facilitates osteoporosis and may promote osteoporotic fractures by modulating NRP2 expression.

Background: Osteoporosis (OP) is a high-incidence bone disease that is prone to osteoporotic fractures (OF), so it has attracted widespread attention.

Aim: This study investigated the specific expression and role of miR-331 in patients with OP and OF. The findings have profound implications for the clinical prevention and treatment of these conditions.

Osteoclast-derived exosomes influence osteoblast differentiation in osteoporosis progression via the lncRNA AW011738/ miR-24-2-5p/ TREM1 axis.

Aims: To investigate the molecular mechanism of osteoclast-derived exosomes in osteoporosis.

Main Methods: RANKL induced osteoclast model was screened for significantly differentially expressed lncRNAs and mRNAs by whole RNA sequencing. Exosomes were characterized using electron microscopy, western blotting and nanosight.

Co contamination of Si: Plating & aging.

Cobalt has emerged as a vital material in 10 nm technology for localized interconnect layers, potentially offering a compelling alternative to Cu-based interconnects. In this study, we subjected the contamination arising from the presence of cobalt atoms in silicon to comprehensive investigation, employing electron transmission electron microscopy (TEM) observations in conjunction with first-principles calculations. The results show that a dense CoSi layer with a thickness of a few nanometers is formed at the interface of cobalt and Si.

Structure Elucidation of a Novel Polysaccharide Isolated from and Establishing Its Antioxidant and Anticancer Properties.

polysaccharides (EFPs) have not been extensively investigated yet in terms of their extraction and biological activity. The orthogonal experimental design was employed in this study to evaluate the optimum yield of EFPs. A maximum yield of 2.

Empowering caregivers of children with bronchiolitis obliterans: The effectiveness of an internet-based follow-up platform.

Objective: Limited evidence on home care and need for long-term individualized follow-up highlight the importance of developing an Internet-based follow-up platform to support caregivers of children with Bronchiolitis Obliterans (BO). This Study aims to explore and test the potential benefits of this platform by comparing family management, medication compliance and clinical systems.

Study Design And Methods: A two-arm, single-blind randomized controlled trial was conducted on 168 children with BO and their families from January 2022 to October 2022.

A Study of Electroplated Nanoporous Copper Using Aberration-Corrected Transmission Electron Microscopy.

Nanoporous Cu foam is widely applied in many fields such as the packaging of electronic power devices. In this study, a sandwich-structured Cu-Zn eutectic alloy precursor composed of CuZn/CuZn/CuZn is prepared through electroplating. The surface layer of the precursor, CuZn, has a flat surface with numerous grain boundaries, which effectively promotes its dealloying behavior.