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Article Abstract
Chiral nitriles are valuable structural motifs found in numerous pharmaceuticals and natural products. This study presents an efficient method for synthesizing chiral nitriles via a cycloaddition reaction between -cyano-substituted ,-unsaturated aldehydes and 3-methyl-1-phenyl-1-pyrazole-5-amine. The transformation is catalyzed by -heterocyclic carbene (NHC) at low loadings, affording the corresponding chiral nitriles in good to excellent yields with excellent enantioselectivities.
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