Changes in heart rate variability parameters following pulsed-field ablation in patients with atrial fibrillation: A systematic review and meta-analysis HRV changes after pulsed-field ablation in AF.

Introduction: Atrial fibrillation (AF) is a prevalent cardiac arrhythmia. Pulmonary vein isolation (PVI) is a cornerstone for catheter ablation for AF. Most recently, pulsed-field ablation (PFA) has emerged as a novel technique that minimizes tissue damage due to its tissue selectivity with promising clinical success.

Association of the Dietary Index for Gut Microbiota With Severity, Renal Function, and Sarcopenia in Patients With Chronic Kidney Disease: A Population-Based Cross-Sectional Study.

Objective: The aim of this research was to clarify the relationship between the Dietary Index for Gut Microbiota (DI-GM) and the severity of chronic kidney disease (CKD), renal function, and the prevalence of sarcopenia in patients with CKD, as well as the role of the Systemic Immune-Inflammation Index (SII) therein.

Method: Using data from the National Health and Nutrition Examination Survey (NHANES) 2007-2018, the study included 2169 participants with CKD. DI-GM was calculated on a scale of 0 to 13, with higher scores indicating a healthier gut microbiome.

Prognostic Value of Multiple Circulating Biomarkers for Ventricular Arrhythmias in Left Ventricular Hypertrabeculation - Longitudinal Cohort Study.

Background: Ventricular arrhythmia (VA) is an independent risk factor for adverse outcomes in patients with left ventricular hypertrabeculation (LVHT). This study explored the predictive value of biomarkers for VAs in LVHT.

Methods And Results: This cohort study retrospectively enrolled 265 LVHT patients (mean [±SD] age 44.

The Efficacy of Left Atrial vs Biatrial Cardioneuroablation in Patients With Vasovagal Syncope: A Randomized Clinical Trial.

Background: Cardioneuroablation has been proposed to be effective in patients with vasovagal syncope, whereas the preferred ablation strategy is undetermined.

Objectives: This study aimed to determine the preferred ablation strategy of cardioneuroablation between the left atrial (LA) and the bilateral atrial (BiA) approach.

Methods: This study was a prospective randomized clinical trial to compare the efficacy of 2 ablation strategies for patients with vasovagal syncope.

The Efficacy of Cardioneuroablation versus Midodrine in Patients with Vasovagal Syncope: Design and Rationale for the CAMPAIGN Trial.

Background: Current treatment strategies for vasovagal syncope (VVS) patients recommended by the guidelines are diverse, but effects of these therapies are still unsatisfactory with respective limitations on the indications. Cardioneuroablation (CNA), an innovative and promising therapy, has shown potently effective against syncopal recurrences in numerous observational studies. Recently, a single-center randomized clinical trial has reported CNA was superior to non-pharmacologic therapy for VVS patients.

Feasibility and safety of pulsed field ablation at the ventricular outflow tract using focal point catheter.

Background: Ventricular arrhythmias commonly originate from the ventricular outflow tract. It remains unexplored whether pulsed field ablation (PFA) can create durable lesions safely at the ventricular outflow tract.

Objective: This study aimed to evaluate the feasibility and safety of a novel PFA catheter to deliver focal ablation to the ventricular outflow tract, especially pulmonary and aortic sinus cusps (PSCs and ASCs).

Effectiveness of cardioneuroablation in different subtypes of vasovagal syncope.

Background: Cardioneuroablation (CNA) has shown encouraging results in patients with vasovagal syncope (VVS). However, data on different subtypes was scarce.

Methods: This observational study retrospectively enrolled 141 patients [mean age: 40 ± 18 years, 51 males (36.

Prognostic value of cardiac deceleration capacity in patients with atrial fibrillation after catheter ablation: A systematic review and meta-analysis.

Introduction: Cather ablation (CA) is a well-recognized treatment alternative for atrial fibrillation (AF) patients despite more than 20% ablation-treated patients suffering from AF recurrence. The underlying mechanism of AF recurrence postablation is probably associated with high cardiac parasympathetic activity, which can be assessed with deceleration capacity (DC) of heart rate. Given that the relationship between DC and AF recurrence is still controversial, this systematic review and meta-analysis was performed to investigate the characteristics of DC in patients with and without AF recurrence, evaluating the prognostic value of DC in AF patients after CA.

Fucosterol exhibits selective antitumor anticancer activity against HeLa human cervical cell line by inducing mitochondrial mediated apoptosis, cell cycle migration inhibition and downregulation of m-TOR/PI3K/Akt signalling pathway.

[This retracts the article DOI: 10.3892/ol.2018.

Identification of Human Global, Tissue and Within-Tissue Cell-Specific Stably Expressed Genes at Single-Cell Resolution.

Stably Expressed Genes (SEGs) are a set of genes with invariant expression. Identification of SEGs, especially among both healthy and diseased tissues, is of clinical relevance to enable more accurate data integration, gene expression comparison and biomarker detection. However, it remains unclear how many global SEGs there are, whether there are development-, tissue- or cell-specific SEGs, and whether diseases can influence their expression.

Association of serum vitamin D status with gestational diabetes mellitus and other laboratory parameters in early pregnant women.

Background: The association between serum 25-hydroxy vitamin D (25(OH)D) status and gestational diabetes mellitus (GDM) gained attention in recent years, however the conclusion is still controversial due to many interfering factors, such as region of living, environment, lifestyle, and food supplements. Other metabolites (laboratory parameters) are also important in reflecting gestational states. This study aimed to investigate the association of serum 25(OH)D status in early pregnancy with GDM and other laboratory parameters in pregnant women.

Efficacy and safety of laser combination therapy and laser alone therapy for keloid: a systematic review and meta-analysis.

To evaluate the efficacy and safety of laser alone therapy and laser combination therapy (mainly combined with other kinds of laser or steroids) for keloid.PubMed, Embase and Web of Science were searched for relevant articles from inception to June 2020. Comprehensive Meta-Analysis software 2.

A Multi-Gene Model Effectively Predicts the Overall Prognosis of Stomach Adenocarcinomas With Large Genetic Heterogeneity Using Somatic Mutation Features.

Background: Stomach adenocarcinoma (STAD) is one of the most common malignancies worldwide with poor prognosis. It remains unclear whether the prognosis is associated with somatic gene mutations.

Methods: In this research, we collected two independent STAD cohorts with both genetic profiling and clinical follow-up data, systematically investigated the association between the prognosis and somatic mutations, and analyzed the influence of heterogeneity on the prognosis-genetics association.

Medical Image Fusion Based on Sparse Representation and PCNN in NSCT Domain.

The clinical assistant diagnosis has a high requirement for the visual effect of medical images. However, the low frequency subband coefficients obtained by the NSCT decomposition are not sparse, which is not conducive to maintaining the details of the source image. To solve these problems, a medical image fusion algorithm combined with sparse representation and pulse coupling neural network is proposed.

Fucosterol exhibits selective antitumor anticancer activity against HeLa human cervical cell line by inducing mitochondrial mediated apoptosis, cell cycle migration inhibition and downregulation of m-TOR/PI3K/Akt signalling pathway.

Cervical cancer greatly contributes to cancer-associated mortalities worldwide. The growing incidence of cervical cancer is of primary concern, and has signaled the need for multiple treatment options. Despite preliminary responses to chemotherapy and/or surgical interventions, the tumors consistently relapse.

LncRNA GAS5 suppresses ovarian cancer by inducing inflammasome formation.

Objective: Long non-coding RNA growth arrest-specific transcript 5 (lncRNA GAS5) is involved in various kinds of cancer. However, the role of lncGAS5 in the development of ovarian cancer remains unclear. In the current study, we explored the cellular mechanism and clinical value of lncRNA GAS5 in ovarian cancer.