Prognostic value of the co-stimulatory molecule OX40 expression in Extranodal Natural Killer/T-cell Lymphoma.

Objective: To explore the clinicopathological features and the prognostic values of the co-stimulatory molecules OX40 and the inducible T-cell co-stimulator (ICOS) in Extranodal Natural Killer/T-cell Lymphoma (ENKTL).

Methods: 82 participants (median age 51 years, 26.8% female) were included in this study.

A Cardiac Magnetic Resonance-Based Risk Stratification for Life-Threatening Ventricular Tachyarrhythmias in Heart Failure: The SNE Score.

Risk stratification for sudden cardiac death (SCD) mainly relies on severely reduced left ventricular ejection fraction (LVEF), but its poor predictive efficacy fails to meet clinical needs. Myocardial scarring identified using cardiac magnetic resonance (CMR) imaging has emerged as a potent risk indicator for SCD and life-threatening ventricular tachyarrhythmias (LTVTA). This study aimed to develop a risk prediction score for SCD and ventricular tachyarrhythmias in symptomatic heart failure.

Potential association between periodontitis and liver function test abnormalities: Results from the National Health and Nutrition Examination Survey (NHANES) 2009-2014.

Background/purpose: Previous studies have indicated that periodontitis was associated with various liver diseases; however, few large-scale population-level studies were available. This study aimed to conduct a comprehensive investigation into the associations between periodontitis and liver function test (LFT) indexes.

Materials And Methods: Data were sourced from 2009 to 2014 the National Health and Nutrition Examination Survey (NHANES) databases, and the study population included 10139 participants.

Global, Regional, and National Burden and Trends of Soft Tissue and Other Extraosseous Sarcomas From 1990 to 2021.

Soft Tissue and Other Extraosseous Sarcomas (STOES) represent a rare and heterogeneous group of malignancies with significant clinical challenges due to their complexity and aggressiveness. Despite their low prevalence, the global impact of STOES is substantial, necessitating a detailed examination of their epidemiology and disease burden. This comprehensive analysis utilized data from the Global Health Data Exchange (GHDx) covering the years 1990 to 2021.

Characterizing anterior and posterior circulation strokes using high-resolution magnetic resonance imaging.

Background And Purpose: High-resolution magnetic resonance imaging (HR-MRI) is increasingly used to assess intracranial atherosclerosis (ICAS). The risks for anterior circulation stroke (ACS) and posterior circulation stroke (PCS) differ, and understanding the factors influencing these differences is important for better clinical management. This study investigates the impact of clinical risk factors on ICAS features in ACS and PCS using HR-MRI, focusing on arterial remodeling patterns.

Early cardiac involvement in patients with hyperthyroidism evaluated by cardiac magnetic resonance feature tracking.

Background: This study aimed to investigate the feasibility of quantitative assessment of myocardial injury in the early stages of the disease by myocardial strain in patients with hyperthyroidism.

Methods And Results: A total of 45 individuals in the hyperthyroid state with at least one index of cardiac involvement (e.g.

Hormone therapy and oral contraceptives in the risk of knee osteoarthritis: a prospective cohort study.

Objective: To evaluate the association of hormone therapy (HT) and oral contraceptives (OC) with the risk of knee osteoarthritis (KOA).

Methods: Using data from the UK Biobank, we included 211,345 women (mean 56.5 y) who were free of KOA and had self-reported data on the use of HT and OC at baseline.

Lack of reproducibility of trial sequential analyses: a meta-epidemiological study.

Systematic reviews and meta-analyses are essential tools for synthesizing evidence from multiple studies. Recently, trial sequential analyses (TSAs) have gained popularity as a component of meta-analyses, helping researchers dynamically monitor evidence as new studies are incorporated. This article introduces a meta-epidemiological study aimed at evaluating the reproducibility of TSAs within systematic reviews published in 2023.

Predictive validity of consensus-based MRI definition of osteoarthritis plus radiographic osteoarthritis for the progression of knee osteoarthritis: A longitudinal cohort study.

Objective: Our previous study showed that magnetic resonance imaging (MRI)-defined tibiofemoral osteoarthritis (MRI-OA), based on a Delphi approach, in combination with radiographic OA (ROA) had a strong predictive validity for the progression of knee OA. This study aimed to compare whether the combination using traditional prediction models was superior to the Light Gradient Boosting Machine (LightGBM) models.

Methods: Data were from the Tasmanian Older Adult Cohort.

The association between endogenous sex hormones and knee osteoarthritis in women: A population-based cohort study.

Background: To describe the associations of endogenous sex hormones with the prevalence and occurrence of knee osteoarthritis (KOA) in women.

Methods: We included 178,280 women (mean 56.0 years) from the UK Biobank who had data on sex hormone-binding globulin (SHBG), testosterone, or estradiol at baseline.

Rural-Urban Disparity in Premature Cancer Mortality in Young People Aged 15-44 Years in China, 2004-2021.

Objective: This study aims to examine and compare premature cancer mortality in young people aged 15-44 years old between rural and urban areas to inform early-onset cancer prevention.

Methods: The data were obtained from the China Death Surveillance Datasets from 2004 to 2021. The study sample consisted of cancer deaths of young people aged 15-44 years old.

Effects of Postoperative Complications on Overall Survival Following Esophagectomy: A Meta-Analysis Using the Restricted Mean Survival Time Analysis.

Objective: This study aims to conduct a comprehensive meta-analysis of the effects of postoperative complications (PCs) on survival following esophagectomy using the restricted mean survival time (RMST) analysis.

Methods: A systematic literature search was performed in PubMed, Embase, Web of Science, Cochrane, and Medline, including articles published up to July 2024. Data were reconstructed from Kaplan-Meier curves, and the difference in RMST (RMSTD) and the RMST/restricted mean time loss (RMTL) ratios were calculated to examine the effects of PCs on overall survival.

The Role of Double-Zero-Event Studies in Evidence Synthesis: Evaluating Robustness Using the Fragility Index.

Rationale: Zero-event counts are common in clinical studies, particularly when assessing rare adverse events. These occurrences can result from low event rates, short follow-up periods, and small sample sizes. When both intervention and control groups report zero events in a clinical trial, the study is referred to as a double-zero-event study, which presents methodological challenges for evidence synthesis.

Causal association between bone mineral density and the risk of joint replacement in patients with osteoarthritis: a Mendelian randomization study.

Population-based studies have been inconsistent in terms of the relationship between bone mineral density (BMD) and the progression of osteoarthritis. This study aimed to evaluate the causal relationship between BMD and the risk of joint replacement in patients with osteoarthritis. We performed a two-sample Mendelian randomization (MR) analysis to determine the association of BMD of the total body, femoral neck, and lumbar spine with the risk of hip and knee replacements.

Femtomolar hydrogen sulfide detection via hybrid small-molecule nano-arrays.

Early disease diagnosis hinges on the sensitive detection of signaling molecules. Among these, hydrogen sulfide (HS) has emerged as a critical player in cardiovascular and nervous system signaling. On-chip immunoassays, particularly nanoarray-based interfacial detection, offer promising avenues for ultra-sensitive analysis due to their confined reaction volumes and precise signal localization.

Intraoperative Parathyroid Hormone Monitoring Criteria in Primary Hyperparathyroidism: A Network Meta-Analysis of Diagnostic Test Accuracy.

Importance: Intraoperative parathyroid hormone (IOPTH) monitoring is recommended by the American Association of Endocrine Surgeons for use during parathyroidectomy for patients with primary hyperparathyroidism (PHPT), but there is no clinician consensus regarding the IOPTH monitoring criteria that optimize diagnostic accuracy.

Objective: To evaluate and rank the diagnostic properties of IOPTH monitoring criteria used during surgery for patients with PHPT.

Data Sources: A bayesian diagnostic test accuracy network meta-analysis (DTA-NMA) was performed, in which peer-reviewed citations from January 1, 1990, to July 22, 2023, were searched for in MEDLINE, Embase, Web of Science, CENTRAL, and CINAHL.

Trial sequential analysis involving same-year studies requires careful temporal ordering.

Trial sequential analysis (TSA) is an increasingly used tool in systematic reviews to monitor synthesized evidence. However, the current practice of TSAs often overlooks the order of same-year studies, which are typically ordered alphabetically based on the last names of the studies' authors by default in the widely used TSA software application. This practice is inappropriate and contrary to the TSA's definition.

Association of prognostic nutritional index with the presence and all-cause mortality of rheumatoid arthritis: the National Health and Nutrition Examination Survey 2003-2018.

Background: The prognostic nutritional index (PNI) is a comprehensive measure of individual immune and nutritional status. This study aimed to evaluate the role of PNI in the presence and mortality of rheumatoid arthritis (RA).

Methods: This study used data of participants aged ≥ 40 years from the National Health and Nutrition Examination Survey (NHANES) 2003-2018.

Evaluating the Causal Effect of Circulating Proteome on Glycemic Traits: Evidence From Mendelian Randomization.

Exploring the mechanisms underlying abnormal glycemic traits is important for deciphering type 2 diabetes and characterizing novel drug targets. This study aimed to decipher the causal associations of circulating proteins with fasting glucose (FG), 2-h glucose after an oral glucose challenge (2hGlu), fasting insulin (FI), and glycated hemoglobin (HbA1c) using large-scale proteome-wide Mendelian randomization (MR) analyses. Genetic data on plasma proteomes were obtained from 10 proteomic genome-wide association studies.

Anticancer role of flubendazole: Effects and molecular mechanisms (Review).

Flubendazole, an anthelmintic agent with a well-established safety profile, has emerged as a promising anticancer drug that has demonstrated efficacy against a spectrum of cancer types over the past decade. Its anticancer properties encompass a multifaceted mechanism of action, including the inhibition of cancer cell proliferation, disruption of microtubule dynamics, regulation of cell cycle, autophagy, apoptosis, suppression of cancer stem cell characteristics, promotion of ferroptosis and inhibition of angiogenesis. The present review aimed to provide a comprehensive overview of the molecular underpinnings of the anticancer activity of flubendazole, highlighting key molecules and regulatory pathways.

Predicting angiogenesis in adrenal pheochromocytoma: the role of modified parameters from contrast-enhanced CT.

Objective: The aim of this study is to investigate the value of modified parameters derived from dual-phase contrast-enhanced computed tomography (CT) in predicting angiogenesis within pheochromocytoma.

Method: A total of 31 patients with pathologically confirmed pheochromocytoma underwent preoperative dual-phase contrast-enhanced CT scanning, wherein modified CT enhancement parameters, namely maximum enhancement difference (∆H) and maximum enhancement velocity (V), were quantified. Subsequently, postoperative specimens were evaluated by pathological section, while microvessel density (MVD) and vascular endothelial growth factor (VEGF) levels were counted.

Predictive value of cardiac magnetic resonance imaging for fatal arrhythmias in structural and nonstructural heart diseases.

Background: The risk stratification for fatal arrhythmias remains inadequate. Cardiac magnetic resonance (CMR) imaging provides a detailed evaluation of arrhythmogenic substrates. This study investigated the predictive capacity of multiparametric CMR for fatal ventricular arrhythmias (VAs) in a heterogeneous disease cohort.