Diagnosis and treatment of Von Hippel-Lindau syndrome: A case series.

The objective of the present case report was to explore the clinical approaches to diagnosing and managing Von Hippel-Lindau (VHL) syndrome. A retrospective review was performed on the clinical presentations, imaging findings and family genetic histories of four patients diagnosed with VHL syndrome. Their clinical features and treatment strategies were systematically analyzed.

Prospective analysis of quantitative EEG indices for predicting functional outcomes in acute ischemic stroke.

Objective: This study aims to assess the effectiveness of quantitative electroencephalography (qEEG) in determining the prognosis of acute ischemic stroke, thus offering a scientific foundation for early prognostic evaluation.

Methods: One hundred sixty-seven patients with acute ischemic stroke were admitted to the Neurology Department of Hebei Provincial People's Hospital between May 2022 and October 2023. All patients received standard treatments, including antiplatelet aggregation and lipid-lowering therapy to stabilize plaques.

Characterizing anterior and posterior circulation strokes using high-resolution magnetic resonance imaging.

Background And Purpose: High-resolution magnetic resonance imaging (HR-MRI) is increasingly used to assess intracranial atherosclerosis (ICAS). The risks for anterior circulation stroke (ACS) and posterior circulation stroke (PCS) differ, and understanding the factors influencing these differences is important for better clinical management. This study investigates the impact of clinical risk factors on ICAS features in ACS and PCS using HR-MRI, focusing on arterial remodeling patterns.

Clinical characterization of diseases associated with anti-N-methyl-D-aspartate receptor encephalitis combined with anti-myelin oligodendrocyte glycoprotein antibodies in adults.

Objective: The aim of this study was to analyze the clinical characteristics of adult patients with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis combined with anti-myelin oligodendrocyte glycoprotein (MOG) antibodies.

Methods: This was a non-randomized controlled study. Clinical data were collected from 17 patients with anti-NMDAR encephalitis combined with anti-MOG antibodies admitted to Xuanwu Hospital, Capital Medical University, from January 2020 to August 2024.

Value evaluation of serum (sdLDLc*HCYc)/HDLc ratio in the stability of intracranial arterial plaques in patients with acute cerebral infarction.

Background: We aimed to analyze the value of serum (sdLDLc*HCYc)/HDLc ratio in the stability of intracranial arterial plaques among patients with acute cerebral infarction.

Methods: A retrospective analysis was conducted on 140 patients with acute cerebral infarction admitted to the neurology department and 101 healthy individuals for regular examinations in our hospital from 2013 to 2019, who were respectively allocated into the study group and the control group. Participants in both groups were measured for serum sdLDLc, HDLc, and HCYc using peroxidase method, enzyme-linked immunosorbent assay, and enzyme method, respectively.

Estimation of the LDL subclasses in ischemic stroke as a risk factor in a Chinese population.

Background: Acute ischemic stroke (AIS) is one of the leading causes of mortality and long-term disability worldwide. Our study aims to clarify the role of low-density lipoproteins (LDL) subclasses in the occurrence of AIS and develop a risk xprediction model based on these characteristics to identify high-risk people.

Methods: Five hundred and sixty-six patients with AIS and 197 non-AIS controls were included in this study.

Atorvastatin Attenuates Cognitive Deficits and Neuroinflammation Induced by Aβ Involving Modulation of TLR4/TRAF6/NF-κB Pathway.

Inflammatory damage aggravates the progression of Alzheimer's disease (AD) and the mechanism of inflammatory damage may provide a new therapeutic window for the treatment of AD. Toll-like receptor 4 (TLR4)-mediated signaling can regulate the inflammatory process. However, changes in TLR4 signaling pathway induced by beta-amyloid (Aβ) have not been well characterized in brain, especially in the hippocampus.

Taxane-derived compounds protect SK-N-SH cells against oxidative stress injury induced by HO.

Objective: Discussed the protection of taxane-derived compounds, 7-deacetyl-taxine B and 5-cinnamoyloxy-taxin B, against oxidative stress injury.

Methods: SK-N-SH cells were pretreated with 7-deacetyl-taxine B, 5-cinnamoyloxy-taxin B or DMSO (control) and then incubated with HO for another 24 h. Cell viability was measured by MTT colorimetric assay.